Light-induced disruption of an acyl hydrazone link as a novel strategy for drug release and activation: isoniazid as a proof-of-concept case

Autor: Eduardo H.S. Sousa, Izaura C.N. Diógenes, Tércio de F. Paulo, Alexandre Lopes Andrade, Idalina M.M. de Carvalho, Edinaira Nunes, Edson Holanda Teixeira, Luiz Gonzaga de França Lopes, Otaciro R. Nascimento, Mayron Alves de Vasconcelos, Ana C. S. Gondim, Luiz Augusto Basso, Davila Zampieri, Anne Drumond Villela, Luiz Gonzaga do Nascimento Neto, Adolfo I. B. Romo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Aldehydes and acyl hydrazines have been employed in a conjugation reaction that produces an acyl hydrazone bridge. A drawback to this linkage is hydrolysis, which prevents its broader use in a controllable manner. We have developed a new strategy for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98395e78e53a8c31f606eb4f2545276
https://doi.org/10.1039/c9qi01172b

Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl

Autor: Eduardo H.S. Sousa, Luiz Gonzaga de França Lopes, Vania Bernardes-Génisson, Remi Chauvin, Tércio de F. Paulo, Carine Duhayon

Publikováno v: Chemical research in toxicology. 34(8)

A chemical activation study of the thiocarbonyl-type antitubercular prodrugs, ethionamide (ETH), thioacetazone (TAZ), and isoxyl (ISO), was performed. Biomimetic oxidation of ethionamide using H2O2 (1 equiv) led to ETH-SO as the only stable S-oxide c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8b38cd8db8eb7d20db1ef7598edce4
https://pubmed.ncbi.nlm.nih.gov/34319702

A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity

Autor: Luiz Gonzaga de França Lopes, Elisane Longhinotti, Mayara Jane Campos de Medeiros, Tércio de F. Paulo, Edinilton Muniz Carvalho, Nilberto R.F. Nascimento, Lisa A. Ridnour, Vania Bernardes-Génisson, Pedro Henrique Bezerra Cabral, Daniel de Lima Pontes, Florêncio Sousa Gouveia Júnior, David A. Wink, Douglas Wagner Franco, Eduardo H.S. Sousa, Remi Chauvin

Publikováno v: Journal of Inorganic Biochemistry
Journal of Inorganic Biochemistry, Elsevier, 2020, 210, pp.111133. ⟨10.1016/j.jinorgbio.2020.111133⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
J Inorg Biochem

International audience; Nitric oxide (NO) and nitroxyl (HNO) have gained broad attention due to their roles in several physiological and pathophysiological processes. Remarkably, these sibling species can exhibit opposing effects including the promot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d169db7ed0820853d372a2fbc3edf8
https://hal.archives-ouvertes.fr/hal-02947857

Chitosan Film Containing an Iron Complex: Synthesis and Prospects for Heterocyclic Aromatic Amines (HAAs) Recognition

Autor: Natanna de A. Aguiar, Elisane Longhinotti, Dieric S. Abreu, Leandro Araujo da Costa, Izaura C.N. Diógenes, Maria A. S. da Silva, Tércio de F. Paulo

Publikováno v: Journal of Agricultural and Food Chemistry. 65:1387-1394

Hybrid organic–inorganic materials have been seen as a promising approach to produce sensors for the detection and/or recognition of heterocyclic aromatic amines (HAAs). This work shows the synthesis of a hybrid film as a result of the incorporatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f0957ade8fd04c161a73ed52d30e4e
https://doi.org/10.1021/acs.jafc.6b03742

A spectroelectrochemical investigation of the heme-based sensor DevS from Mycobacterium tuberculosis: a redox versus oxygen sensor

Autor: Eduardo H.S. Sousa, Marta S. P. Carepo, Tércio de F. Paulo, Giamwemberg A. Barreto, Ana C. S. Gondim, Izaura C.N. Diógenes, Luiz Gonzaga de França Lopes, Wellinson G. Guimarães, Paul V. Bernhardt

Publikováno v: The FEBS journalReferences. 286(21)

Tuberculosis is one of the oldest known infectious diseases, responsible for millions of deaths annually around the world. The ability of Mycobacterium tuberculosis (Mtb) to enter into a dormant state has been considered integral to the success of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e88651cff47840a08706b09260abb7
https://pubmed.ncbi.nlm.nih.gov/31254441