Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Tércio de F. Paulo"'
1
Light-induced disruption of an acyl hydrazone link as a novel strategy for drug release and activation: isoniazid as a proof-of-concept case
Autor: Eduardo H.S. Sousa, Izaura C.N. Diógenes, Tércio de F. Paulo, Alexandre Lopes Andrade, Idalina M.M. de Carvalho, Edinaira Nunes, Edson Holanda Teixeira, Luiz Gonzaga de França Lopes, Otaciro R. Nascimento, Mayron Alves de Vasconcelos, Ana C. S. Gondim, Luiz Augusto Basso, Davila Zampieri, Anne Drumond Villela, Luiz Gonzaga do Nascimento Neto, Adolfo I. B. Romo
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Aldehydes and acyl hydrazines have been employed in a conjugation reaction that produces an acyl hydrazone bridge. A drawback to this linkage is hydrolysis, which prevents its broader use in a controllable manner. We have developed a new strategy for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98395e78e53a8c31f606eb4f2545276
https://doi.org/10.1039/c9qi01172b
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2
Photophysical properties of push-π-pull type chromophores of aryl-substituted bipyridines in different solvents
Autor: Lucas F. Bezerra, Elisane Longhinotti, Idalina M.M. de Carvalho, Adolfo I.B. Romo, Tércio de F. Paulo, Dieric S. Abreu, Marcelo Henrique Gehlen, Izaura C.N. Diógenes, Monilson P. dos Reis
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Photophysical studies of 4′-methyl-2,2′-bipyridine derivatized with the polycyclic aromatic hydrocarbons (PAHs) anthracene (mbpy-anth), naphthalene (mbpy-naph), and pyrene (mbpy-pyr) were acquired in different solvents. While the absorption spect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f842a7f6dbde0ac35c3517000058d6f8
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3
Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl
Autor: Eduardo H.S. Sousa, Luiz Gonzaga de França Lopes, Vania Bernardes-Génisson, Remi Chauvin, Tércio de F. Paulo, Carine Duhayon
Publikováno v: Chemical research in toxicology. 34(8)
A chemical activation study of the thiocarbonyl-type antitubercular prodrugs, ethionamide (ETH), thioacetazone (TAZ), and isoxyl (ISO), was performed. Biomimetic oxidation of ethionamide using H2O2 (1 equiv) led to ETH-SO as the only stable S-oxide c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8b38cd8db8eb7d20db1ef7598edce4
https://pubmed.ncbi.nlm.nih.gov/34319702
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4
A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity
Autor: Luiz Gonzaga de França Lopes, Elisane Longhinotti, Mayara Jane Campos de Medeiros, Tércio de F. Paulo, Edinilton Muniz Carvalho, Nilberto R.F. Nascimento, Lisa A. Ridnour, Vania Bernardes-Génisson, Pedro Henrique Bezerra Cabral, Daniel de Lima Pontes, Florêncio Sousa Gouveia Júnior, David A. Wink, Douglas Wagner Franco, Eduardo H.S. Sousa, Remi Chauvin
Publikováno v: Journal of Inorganic Biochemistry
Journal of Inorganic Biochemistry, Elsevier, 2020, 210, pp.111133. ⟨10.1016/j.jinorgbio.2020.111133⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
J Inorg Biochem
International audience; Nitric oxide (NO) and nitroxyl (HNO) have gained broad attention due to their roles in several physiological and pathophysiological processes. Remarkably, these sibling species can exhibit opposing effects including the promot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d169db7ed0820853d372a2fbc3edf8
https://hal.archives-ouvertes.fr/hal-02947857
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5
Pentacyanoferrate(II) complex of pyridine-4- and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities
Autor: Eduardo H.S. Sousa, Edinilton Muniz Carvalho, Luiz Gonzaga de França Lopes, Bruno Lopes Abbadi, Alix Saquet, Remi Chauvin, Vania Bernardes-Génisson, Tércio de F. Paulo, Cristiano Valim Bizarro, Nilberto R.F. Nascimento, Fernanda Souza Macchi, Talles Luann Abrantes Ferreira, Rafael Campos
Publikováno v: Journal of Biological Inorganic Chemistry
Journal of Biological Inorganic Chemistry, Springer Verlag, 2020, 25 (6), pp.887-901. ⟨10.1007/s00775-020-01805-z⟩
International audience; A pharmacophore design approach, based on the coordination chemistry of an intimate molecular hybrid of active metabolites of pro-drugs, known to release active species upon enzymatic oxidative activation, is devised. This is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cbd00d906259aee57092ae3f6395e5
https://hal.archives-ouvertes.fr/hal-02948991
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6
Aryl-Substituted Ruthenium(II) Complexes: A Strategy for Enhanced Photocleavage and Efficient DNA Binding
Autor: Tércio de F. Paulo, Luiz Gonzaga de França Lopes, Idalina M.M. de Carvalho, Ana C. S. Gondim, Eduardo H.S. Sousa, Rômulo A. Ando, Marcelo Henrique Gehlen, Edson Holanda Teixeira, Felipe Diógenes Abreu, Mayron Alves de Vasconcelos
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Ruthenium polypyridine complexes have shown promise as agents for photodynamic therapy (PDT) and tools for molecular biology (chromophore-assisted light inactivation). To accomplish these tasks, it is important to have at least target selectivity and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179bacd9bbce1f7facdd30709542a6ed
https://doi.org/10.1021/acs.inorgchem.7b01108
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7
Chitosan Film Containing an Iron Complex: Synthesis and Prospects for Heterocyclic Aromatic Amines (HAAs) Recognition
Autor: Natanna de A. Aguiar, Elisane Longhinotti, Dieric S. Abreu, Leandro Araujo da Costa, Izaura C.N. Diógenes, Maria A. S. da Silva, Tércio de F. Paulo
Publikováno v: Journal of Agricultural and Food Chemistry. 65:1387-1394
Hybrid organic–inorganic materials have been seen as a promising approach to produce sensors for the detection and/or recognition of heterocyclic aromatic amines (HAAs). This work shows the synthesis of a hybrid film as a result of the incorporatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f0957ade8fd04c161a73ed52d30e4e
https://doi.org/10.1021/acs.jafc.6b03742
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9
A spectroelectrochemical investigation of the heme-based sensor DevS from Mycobacterium tuberculosis: a redox versus oxygen sensor
Autor: Eduardo H.S. Sousa, Marta S. P. Carepo, Tércio de F. Paulo, Giamwemberg A. Barreto, Ana C. S. Gondim, Izaura C.N. Diógenes, Luiz Gonzaga de França Lopes, Wellinson G. Guimarães, Paul V. Bernhardt
Publikováno v: The FEBS journalReferences. 286(21)
Tuberculosis is one of the oldest known infectious diseases, responsible for millions of deaths annually around the world. The ability of Mycobacterium tuberculosis (Mtb) to enter into a dormant state has been considered integral to the success of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e88651cff47840a08706b09260abb7
https://pubmed.ncbi.nlm.nih.gov/31254441
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