Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Téo Fournier"'
Autor:
Andreas Tsouris, Téo Fournier, Anne Friedrich, Jing Hou, Maitreya J Dunham, Joseph Schacherer
Publikováno v:
PLoS Genetics, Vol 20, Iss 1, p e1011119 (2024)
Assessing the complexity and expressivity of traits at the species level is an essential first step to better dissect the genotype-phenotype relationship. As trait complexity behaves dynamically, the classic dichotomy between monogenic and complex tr
Externí odkaz:
https://doaj.org/article/1552058c91234aa8a2f3ede0be85c7ae
Autor:
Téo Fournier, Jean-Sébastien Gounot, Kelle Freel, Corinne Cruaud, Arnaud Lemainque, Jean-Marc Aury, Patrick Wincker, Joseph Schacherer, Anne Friedrich
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 10, Pp 3243-3250 (2017)
Genetic variation in natural populations represents the raw material for phenotypic diversity. Species-wide characterization of genetic variants is crucial to have a deeper insight into the genotype-phenotype relationship. With the advent of new sequ
Externí odkaz:
https://doaj.org/article/f5eb8f4a820d4787b034aef493e745a3
Publikováno v:
eLife, Vol 8 (2019)
Genome-wide association studies (GWAS) allow to dissect complex traits and map genetic variants, which often explain relatively little of the heritability. One potential reason is the preponderance of undetected low-frequency variants. To increase th
Externí odkaz:
https://doaj.org/article/6aaf094c83824bf79f7af9647f9f8e55
Autor:
Aubin Fleiss, Samuel O'Donnell, Téo Fournier, Wenqing Lu, Nicolas Agier, Stéphane Delmas, Joseph Schacherer, Gilles Fischer
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008332 (2019)
Genome engineering is a powerful approach to study how chromosomal architecture impacts phenotypes. However, quantifying the fitness impact of translocations independently from the confounding effect of base substitutions has so far remained challeng
Externí odkaz:
https://doaj.org/article/26b5802e9fd0491c954331f99f9a0b68
Autor:
Jing Hou, Anastasie Sigwalt, Téo Fournier, David Pflieger, Jackson Peter, Jacky de Montigny, Maitreya J. Dunham, Joseph Schacherer
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 1106-1114 (2016)
Mendelian traits are considered to be at the lower end of the complexity spectrum of heritable phenotypes. However, more than a century after the rediscovery of Mendel’s law, the global landscape of monogenic variants, as well as their effects and
Externí odkaz:
https://doaj.org/article/54ae1eb6afa8407483bc721bf715257f
Autor:
Samuel O’Donnell, Jia-Xing Yue, Omar Abou Saada, Nicolas Agier, Claudia Caradec, Thomas Cokelaer, Matteo De Chiara, Stéphane Delmas, Fabien Dutreux, Téo Fournier, Anne Friedrich, Etienne Kornobis, Jing Li, Zepu Miao, Lorenzo Tattini, Joseph Schacherer, Gianni Liti, Gilles Fischer
SUMMARYAs population genomics is transitioning from single reference genomes to pangenomes, major improvements in terms of genome contiguity, phylogenetic sampling, haplotype phasing and structural variant (SV) calling are required. Here, we generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fc9e59e202c5bd192e653daf3d837ec
https://doi.org/10.1101/2022.10.04.510633
https://doi.org/10.1101/2022.10.04.510633
Autor:
Joseph Schacherer, Téo Fournier
Publikováno v:
Current Opinion in Genetics & Development. 47:48-53
Dissecting the genetic basis of natural phenotypic variation is a major goal in biology. We know that most traits are strongly heritable. However, their genetic architecture is a long-standing question, which is unfortunately confounded by the lack o
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Genome-wide association studies (GWAS) allows to dissect the genetic basis of complex traits at the population level1. However, despite the extensive number of trait-associated loci found, they often fail to explain a large part of the observed pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d7f68e6bde706f5b7c674f8f481864
Autor:
Jackson Peter, Joseph Schacherer, Jing Hou, Maitreya J. Dunham, Anastasie Sigwalt, Jacky de Montigny, David Pflieger, Téo Fournier
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 1106-1114 (2016)
SummaryMendelian traits are considered to be at the lower end of the complexity spectrum of heritable phenotypes. However, more than a century after the rediscovery of Mendel’s law, the global landscape of monogenic variants, as well as their effec
Autor:
Téo Fournier, Nicolas Agier, Samuel O’Donnell, Joseph Schacherer, Stéphane Delmas, Gilles Fischer, Aubin Fleiss
Genome engineering is a powerful approach to study how chromosomal architecture impacts phenotypes. However, quantifying the fitness impact of translocations independently from the confounding effect of base substitutions has so far remained challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2437f9e204a3e4aeb6efe1045a68289c
https://doi.org/10.1101/415349
https://doi.org/10.1101/415349