Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Tânia S, Morais"'
Autor:
Tânia S. Morais
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 889 (2024)
In the search for innovative, selective, effective, and safer treatment strategies, hybrid drugs have gained worldwide momentum [...]
Externí odkaz:
https://doaj.org/article/2cea9957252445a9905fed557a436948
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/436ef4e81b1b47cea683417cc941e5fc
Autor:
Tânia S. Morais, Fernanda Marques, Paulo J. Amorim Madeira, Maria Paula Robalo, Maria Helena Garcia
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 862 (2022)
Ruthenium complexes are emerging as one of the most promising classes of complexes for cancer therapy. However, their limited aqueous solubility may be the major limitation to their potential clinical application. In view and to contribute to the pro
Externí odkaz:
https://doaj.org/article/4737e97965264950bdf9bf22307cbdb4
Autor:
Fernanda Marques, Sílvia A. Sousa, Jorge H. Leitão, Tânia S. Morais, Yann Le Gal, Dominique Lorcy
Publikováno v:
Annals of Medicine, Vol 53, Iss sup1, Pp S39-S40 (2021)
AbstractIntroduction Au(III) complexes with dithiolene ligands have been used as molecular conductors and magnetic materials [1]. These compounds feature square planar geometries, as that for cisplatin the Pt(II)-based compound in clinical use as che
Externí odkaz:
https://doaj.org/article/fec4892a4a304b40a5308d5974aec651
Autor:
Rúben D. M. Silva, João Franco Machado, Kyle Gonçalves, Francisco M. Lucas, Salete Batista, Rita Melo, Tânia S. Morais, João D. G. Correia
Publikováno v:
Molecules, Vol 26, Iss 23, p 7349 (2021)
Considering our interest in the use of peptides as potential target-specific drugs or as delivery vectors of metallodrugs for various biomedical applications, it is crucial to explore improved synthetic methodologies to accomplish the highest peptide
Externí odkaz:
https://doaj.org/article/2d806bed5d9a4f768b09777280cd7c39
Autor:
João Franco Machado, Fernanda Marques, Teresa Pinheiro, Maria J. Villa de Brito, Gonzalo Scalese, Leticia Pérez‐Díaz, Lucía Otero, João P. M. António, Dinorah Gambino, Tânia S. Morais
Publikováno v:
ChemMedChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7142d64823cf387b05d60dbbe12df980
https://doi.org/10.1002/cmdc.202300074
https://doi.org/10.1002/cmdc.202300074
Publikováno v:
Molecules, Vol 26, Iss 11, p 3153 (2021)
Cisplatin and derivatives are highly effective in the treatment of a wide range of cancer types; however, these metallodrugs display low selectivity, leading to severe side effects. Additionally, their administration often results in the development
Externí odkaz:
https://doaj.org/article/1578776fe1c44461a93607fa9e19a2ff
Publikováno v:
BioMetals. 34:1029-1042
The interaction between human serum transferrin (hTf) and three promising organometallic Ru (II)- (η5-C5H5) derived complexes, that have already shown strong in vitro cytotoxicity towards human cancer cell lines, has been investigated using fluoresc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50facf2a3d1514fe4bfd06f74641e149
https://doi.org/10.1007/s10534-021-00325-w
https://doi.org/10.1007/s10534-021-00325-w
Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo
Autor:
Lurdes Gano, Marco Cavaco, João D. G. Correia, Darren Wragg, Vera Neves, Vera F. C. Ferreira, Tânia S. Morais, Claudia Schmidt, Rúben D M Silva, Filipa Mendes, Angela Casini, Ben Woods
Publikováno v:
Bioconjugate Chemistry. 32:1399-1408
The biomedical application of discrete supramolecular metal-based structures, specifically self-assembled metallacages, is still an emergent field of study. Capitalizing on the knowledge gained in recent years on the development of 3-dimensional (3D)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffcc9aee0c5117cf608c2fd096783cc1
https://doi.org/10.1021/acs.bioconjchem.0c00659
https://doi.org/10.1021/acs.bioconjchem.0c00659
Autor:
Robert M. Reich, Corazon Frias, Tânia S. Morais, Marcel König, Marie Ahrweiler, Fritz E. Kühn, Jonas F. Schlagintweit, Eva‐Maria H. J. Esslinger, Christian H. G. Jakob, Nicola L Wilke, Fernanda Marques, João Franco Machado, Jerico Frias, Aram Prokop, João D. G. Correia
Publikováno v:
Journal of medicinal chemistry. 64(21)
The synthesis and antiproliferative activity of Mes- and iPr-substituted gold(I) bis(1,2,3-triazol-5-ylidene) complexes in various cancer cell lines are reported, showing nanomolar IC50 values of 50 nM (lymphoma cells) and 500 nM (leukemia cells), re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fc983623881573e47735462b6986ae
https://pubmed.ncbi.nlm.nih.gov/34670090
https://pubmed.ncbi.nlm.nih.gov/34670090