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Akademický článek

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Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells

Autor: H, Sakamoto, T, Mashima, S, Sato, Y, Hashimoto, T, Yamori, T, Tsuruo

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(8)

Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal, a side-product of glycolysis. We previously reported that GLO1 was a resistant factor to antitumor agent-induced apoptosis, and that S-p-bromobenzylglutathione

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f8748462257e39c2b05b16229b8c092
https://pubmed.ncbi.nlm.nih.gov/11489834

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Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity

Autor: Y, Komatsu, K Y, Tomizaki, M, Tsukamoto, T, Kato, N, Nishino, S, Sato, T, Yamori, T, Tsuruo, R, Furumai, M, Yoshida, S, Horinouchi, H, Hayashi

Publikováno v: Cancer research. 61(11)

Cyclic hydroxamic-acid-containing peptide 1 (CHAP1), designed as a hybrid of trichostatin A and trapoxin, is a lead compound for the development of potent inhibitors of histone deacetylase (HDAC). In this study, we synthesized a series of CHAP deriva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1c030732609c56f0f30919e62c948d2
https://pubmed.ncbi.nlm.nih.gov/11389076

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Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis

Autor: T, Oyama, Y, Miyoshi, K, Koyama, H, Nakagawa, T, Yamori, T, Ito, H, Matsuda, H, Arakawa, Y, Nakamura

Publikováno v: Genes, chromosomescancer. 29(1)

Metastasis, a major factor contributing to poor prognosis of cancer patients, is caused by a complex series of events that involve many genes. To investigate this process, we analyzed by differential display three cell lines that had been established

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcc679326fe5381f1ad6ccb9afb42b0d
https://pubmed.ncbi.nlm.nih.gov/10918388

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[Results of molecular screening of anti-cancer agents. 8. Results of screening of possible anti-cancer agents in Japan]

Autor: T, Yamori, T, Ando, S, Uehara, M, Ono, M, Kawano, I, Saiki, M, Naito, Y, Hayakawa, T, Tsuruo, Y, Sugimoto, K, Kiyomiya, T, Majima

Publikováno v: Gan to kagaku ryoho. Cancerchemotherapy. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44f37986aa3a7404c02a01f36f96262b
https://pubmed.ncbi.nlm.nih.gov/10780176

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[Results of the evaluation of anti-cancer agents by using human cancer cell panels: details of interpretation]

Autor: T, Yamori

Publikováno v: Gan to kagaku ryoho. Cancerchemotherapy. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14e06ba719696388f90fcf714341286a
https://pubmed.ncbi.nlm.nih.gov/10780177

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Anti-tumor effect of N-beta-alanyl-5-S-glutathionyldihydroxyphenylalanine (5-S-GAD), a novel anti-bacterial substance from an insect

Autor: N, Akiyama, M, Hijikata, A, Kobayashi, T, Yamori, T, Tsuruo, S, Natori

Publikováno v: Anticancer research. 20(1A)

We examined the anti-tumor effect of 5-S-GAD, a novel potent inhibitor of protein tyrosine kinases, isolated from the flesh fly in order to investigate the potential use of this compound as an anti-tumor agent.In vitro growth inhibition was evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d1d873a207543aca3ff038a57ee5f52a
https://pubmed.ncbi.nlm.nih.gov/10769680

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Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel

Autor: T, Yamori, A, Matsunaga, S, Sato, K, Yamazaki, A, Komi, K, Ishizu, I, Mita, H, Edatsugi, Y, Matsuba, K, Takezawa, O, Nakanishi, H, Kohno, Y, Nakajima, H, Komatsu, T, Andoh, T, Tsuruo

Publikováno v: Cancer research. 59(16)

We synthesized a novel anticancer agent MS-247 (2-[[N-[1-methyl-2-[5-[N-[4-[N,N-bis(2-chloroethyl) amino] phenyl]] carbamoyl]-1H-benzimidazol-2-yl] pyrrol-4-yl] carbamoyl] ethyldimethylsulfonium di-p-toluenesulfonate) that has a netropsin-like moiety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f14d0e8fe769fd1d5ef82e5be42a58f
https://pubmed.ncbi.nlm.nih.gov/10463605

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FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis

Autor: I, Naasani, H, Seimiya, T, Yamori, T, Tsuruo

Publikováno v: Cancer research. 59(16)

To facilitate the search for candidate telomerase inhibitors, we exploited the database of the disease-oriented screening program (DOS) available in our facility by using COMPARE analysis. In primary and arbitrary screening, we were able to identify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb2312375fc1bb079140653fb6aacce1
https://pubmed.ncbi.nlm.nih.gov/10463599

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