Zobrazeno 1 - 10
of 10 718
pro vyhledávání: '"T, Ueno"'
Autor:
François Bertucci, Arnaud Guille, Florence Lerebours, Michele Ceccarelli, Najeeb Syed, José Adélaïde, Pascal Finetti, Naoto T. Ueno, Steven Van Laere, Patrice Viens, Alexandre De Nonneville, Anthony Goncalves, Daniel Birnbaum, Céline Callens, Davide Bedognetti, Emilie Mamessier
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Neoadjuvant chemotherapy (NACT) became a standard treatment strategy for patients with inflammatory breast cancer (IBC) because of high disease aggressiveness. However, given the heterogeneity of IBC, no molecular feature reliably
Externí odkaz:
https://doaj.org/article/1068ae1848944ff180c01ffd49e76be5
Autor:
Jangsoon Lee, Kumiko Kida, Jiwon Koh, Huey Liu, Ganiraju C. Manyam, Young Jin Gi, Dileep R. Rampa, Asha S. Multani, Jing Wang, Gitanjali Jayachandran, Dae-Won Lee, James M. Reuben, Aysegul Sahin, Lei Huo, Debu Tripathy, Seock-Ah Im, Naoto T. Ueno
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Background Anti-HER2 therapies, including the HER2 antibody–drug conjugates (ADCs) trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan (T-DXd), have led to improved survival outcomes in patients with HER2-overexpressing (HER2+) metast
Externí odkaz:
https://doaj.org/article/96dec9fe852b4c2f9909c30d5560016b
Autor:
Hui Chen, Qingqing Ding, Laila Khazai, Li Zhao, Senthil Damodaran, Jennifer K. Litton, Gaiane M. Rauch, Clinton Yam, Jeffrey T. Chang, Sahil Seth, Bora Lim, Alastair M. Thompson, Elizabeth A. Mittendorf, Beatriz Adrada, Kiran Virani, Jason B. White, Elizabeth Ravenberg, Xingzhi Song, Rosalind Candelaria, Banu Arun, Naoto T. Ueno, Lumarie Santiago, Sadia Saleem, Sausan Abouharb, Rashmi K. Murthy, Nuhad Ibrahim, Mark J. Routbort, Aysegul Sahin, Vicente Valero, William Fraser Symmans, Debu Tripathy, Wei-Lien Wang, Stacy Moulder, Lei Huo
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: Recent advances have been made in targeting the phosphoinositide 3-kinase pathway in breast cancer. Phosphatase and tensin homolog (PTEN) is a key component of that pathway. Objective: To understand the changes in PTEN expression over the
Externí odkaz:
https://doaj.org/article/d6308ee798424003bf82ce6d0277871d
Autor:
Kuppusamy Balamurugan, Dipak K. Poria, Saadiya W. Sehareen, Savitri Krishnamurthy, Wei Tang, Lois McKennett, Veena Padmanaban, Kelli Czarra, Andrew J. Ewald, Naoto T. Ueno, Stefan Ambs, Shikha Sharan, Esta Sterneck
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Metastatic progression of epithelial cancers can be associated with epithelial-mesenchymal transition (EMT) including transcriptional inhibition of E-cadherin (CDH1) expression. Recently, EM plasticity (EMP) and E-cadherin–mediated, cluster-based m
Externí odkaz:
https://doaj.org/article/502009f78c0b40278ce52d20abc8b4b1
Autor:
A. Iesato, T. Ueno, Y. Takahashi, A. Kataoka, Y. Matsunaga, S. Saeki, Y. Ozaki, Y. Inoue, T. Maeda, N. Uehiro, T. Kobayashi, T. Sakai, T. Takano, T. Kogawa, S. Kitano, M. Ono, T. Osako, S. Ohno
Publikováno v:
Breast, Vol 68, Iss , Pp S71- (2023)
Externí odkaz:
https://doaj.org/article/3fe0d7e98680440d95b9eef4a17cb3cc
Autor:
Lucia Ruojia Wu, Peng Dai, Michael Xiangjiang Wang, Sherry Xi Chen, Evan N. Cohen, Gitanjali Jayachandran, Jinny Xuemeng Zhang, Angela V. Serrano, Nina Guanyi Xie, Naoto T. Ueno, James M. Reuben, Carlos H. Barcenas, David Yu Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Highly multiplexed ddPCR for sensitive nucleic acid quantitation remains challenging due to limited fluorescence channels. Here the authors report quantitative amplicon sequencing (QASeq), a PCR-based molecular barcoding NGS approach which is compati
Externí odkaz:
https://doaj.org/article/4d7f4e4784404a73a971f604e13766e8
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The ubiquitination of SKP2, an oncoprotein, is controlled by its E3 ligases, including APC/CFZR1 and deubiquitinases such as USP10. We identified a two-gene signature for the ubiquitination of SKP2, consisting of the copy number of FZR1 comp
Externí odkaz:
https://doaj.org/article/1149c03f182b47339501a7bdd90c293f
Autor:
Megumi Kai, Angela N. Marx, Diane D. Liu, Yu Shen, Hui Gao, James M. Reuben, Gary Whitman, Savitri Krishnamurthy, Merrick I. Ross, Jennifer K. Litton, Bora Lim, Nuhad Ibrahim, Takahiro Kogawa, Naoto T. Ueno
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Talimogene laherparepvec (T-VEC) is an immunotherapy that generates local tumor lysis and systemic antitumor immune response. We studied the efficacy of intratumoral administration of T-VEC as monotherapy for inoperable locoregional recurren
Externí odkaz:
https://doaj.org/article/c37b0ab005ba4205ac526ecb4d11aff8
Autor:
Emilly S. Villodre, Xiaoding Hu, Richard Larson, Pascal Finetti, Kristen Gomez, Wintana Balema, Shane R. Stecklein, Ginette Santiago‐Sanchez, Savitri Krishnamurthy, Juhee Song, Xiaoping Su, Naoto T. Ueno, Debu Tripathy, Steven Van Laere, François Bertucci, Pablo Vivas‐Mejía, Wendy A. Woodward, Bisrat G. Debeb
Publikováno v:
Molecular Oncology, Vol 15, Iss 10, Pp 2752-2765 (2021)
Inflammatory breast cancer (IBC) is an aggressive form of primary breast cancer characterized by rapid onset and high risk of metastasis and poor clinical outcomes. The biological basis for the aggressiveness of IBC is still not well understood and n
Externí odkaz:
https://doaj.org/article/8e186a4924364ac4b8997f8fc8947ced
Autor:
Wintana Balema, Diane Liu, Yu Shen, Randa El‐Zein, Bisrat G. Debeb, Megumi Kai, Beth Overmoyer, Kathy D. Miller, Huong T. Le‐Petross, Naoto T. Ueno, Wendy A. Woodward
Publikováno v:
Cancer Medicine, Vol 10, Iss 18, Pp 6261-6272 (2021)
Abstract Background Inflammatory breast cancer (IBC) is a clinical diagnosis. Here, we examined the association of a “classic” triad of clinical signs, swollen involved breast, nipple change, and diffuse skin change, with overall survival (OS). M
Externí odkaz:
https://doaj.org/article/71742e0526d545248a9ccf667e9f4628