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FcγRIIB Regulates Nasal and Oral Tolerance: A Role for Dendritic Cells

Autor: Wendy Jansen, Georg Kraal, Joop M L M van Helvoort, Reina E. Mebius, Lisette A. van Berkel, Sjef S Verbeek, Janneke N. Samsom, Wendy W. J. Unger, T. Thepen

Publikováno v: The Journal of Immunology. 174:5279-5287

Mucosal tolerance prevents the body from eliciting productive immune responses against harmless Ags that enter the body via the mucosae, and is mediated by the induction of regulatory T cells that differentiate in the mucosa-draining lymph nodes (LN)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb76bd27f44f0962973848aa012f944
https://doi.org/10.4049/jimmunol.174.9.5279

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Macrophages Play a Dual Role during Pulmonary Tuberculosis in Mice

Autor: T. Thepen, Tom van der Poll, Sandrine Florquin, Sebastiaan Weijer, Jan G. J. van de Winkel, Nico van Rooijen, Jaklien C. Leemans

Publikováno v: The Journal of Infectious Diseases, 191(1), 65-74. Oxford University Press
Journal of infectious diseases, 191(1), 65-74. Oxford University Press
Journal of Infectious Diseases, 191(1), 65-74. Oxford University Press
Leemans, J C, Thepen, T, Weijer, S, Florquin, S, van Rooijen, N, van de Winkel, J G & van der Poll, T 2005, ' Macrophages play a dual role during pulmonary tuberculosis in mice ', Journal of Infectious Diseases, vol. 191, no. 1, pp. 65-74 . https://doi.org/10.1086/426395

Pulmonary macrophages provide the preferred hiding and replication site of Mycobacterium tuberculosis but display antimicrobial functions. This raises questions regarding the role of macrophages during tuberculosis. We depleted lungs of activated mac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f612bec16be8662dfc361ef3d6bbfc
https://doi.org/10.1086/426395

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Mast Cells and Eosinophils in Feline Allergic Dermatitis: A Qualitative and Quantitative Analysis

Autor: J. P. Koeman, Petra J. Roosje, T. Thepen, Ton Willemse

Publikováno v: Journal of Comparative Pathology. 131:61-69

Mast cells (MCs) and eosinophils are prominent in the perivascular infiltrate of cats with allergic dermatitis. In the skin of allergic cats MCs were mainly observed diffusely in the superficial dermis, while eosinophils were found mainly in the deep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684910985379be1a90f51cbea30d8647
https://doi.org/10.1016/j.jcpa.2004.01.005

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Interleukin 4-Producing CD4+ T Cells in the Skin of Cats with Allergic Dermatitis

Autor: T. Thepen, P. J. Roosje, Gregg A. Dean, Victor P.M.G. Rutten, Ton Willemse

Publikováno v: Veterinary Pathology. 39:228-233

Lesional skin of cats with allergic dermatitis has a cellular infiltrate and a CD4/CD8 ratio comparable to that in humans with atopic dermatitis. CD4+ helper T cells and in particular cells belonging to the Th2 subset play an important role in diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c15746b350f029f991cbd5282665ca
https://doi.org/10.1354/vp.39-2-228

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Heterogeneity within tissue-specific macrophage and dendritic cell populations during cutaneous inflammation in atopic dermatitis

Autor: T. Thepen, R.C.M. Kiekens, Edward F. Knol, A.J. Oosting, I. C. Bihari, J.G.J. van de Winkel, C. A. F. M. Bruijnzeel-Koomen

Publikováno v: British Journal of Dermatology. 145:957-965

Background Macrophages and dendritic cells may play a role in chronicity of atopic dermatitis (AD); however, so far only limited data are documented on the distribution of these cells in the skin during cutaneous inflammation. Objectives To gain bett

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0599464ebff2e4177df519d4a5c49e18
https://doi.org/10.1046/j.1365-2133.2001.04508.x

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Interleukin 4 and interferon-γ expression of the dermal infiltrate in patients with erythroderma and mycosis fungoides. An immuno-histochemical study

Autor: W. A. van Vloten, T. Thepen, Vigfús Sigurdsson, I. C. Bihari, Carla A.F.M. Bruijnzeel-Koomen, J. Toonstra

Publikováno v: Journal of Cutaneous Pathology. 27:429-435

BACKGROUND Erythroderma, or generalized erythema of the skin, may result from different causes. At present it is unclear whether the underlying patho-mechanisms that lead to erythroderma are identical or different depending on the original disease. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb54b184e1a3b276518f5695bafb0432
https://doi.org/10.1034/j.1600-0560.2000.027009429.x

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Modulation of the atopy patch test reaction by topical corticosteroids and tar

Autor: T. Thepen, Hannes Riedl, Elisabeth G. Langeveld-Wildschut, Ilse C. Biharia, Piet L.B. Bruijnzeel, Carla A.F.M. Bruijnzeel-Koomen

Publikováno v: Journal of Allergy and Clinical Immunology. 106:737-743

Background: Pharmacologic studies in atopic eczema (AE) are difficult to standardize. Patients with AE differ in the stage of their skin disease (acute, subacute, chronic). Objective: This study was designed to assess macroscopic and microscopic effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f29da4a9b9bc972f1532dc22dbfd807
https://doi.org/10.1067/mai.2000.109831

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Expression of Fc receptors for IgG during acute and chronic cutaneous inflammation in atopic dermatitis

Autor: Rebecca C.M. Kiekens, I. C. Bihari, Carla A.F.M. Bruijnzeel-Koomen, Edward F. Knol, J.G.J. van de Winkel, T. Thepen

Publikováno v: British Journal of Dermatology. 142:1106-1113

Atopic dermatitis is an allergic skin disease characterized by elevated total and antigen-specific serum IgE and IgG4 levels. In acute and chronic cutaneous inflammation, large cellular infiltrates including T cells, dendritic cells and macrophages a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3add741b9e345852861b546cea772cb2
https://doi.org/10.1046/j.1365-2133.2000.03534.x

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