Preparing glycomics data for robust statistical analysis with GlyCompareCT

Autor: Yujie Zhang, Sridevi Krishnan, Bokan Bao, Austin W.T. Chiang, James T. Sorrentino, Song-Min Schinn, Benjamin P. Kellman, Nathan E. Lewis

Publikováno v: STAR Protocols, Vol 4, Iss 2, Pp 102162- (2023)

Summary: GlyCompareCT is a portable command-line tool to facilitate downstream glycomic data analyses, by addressing data inherent sparsity and non-independence. Inputting glycan abundances, users can run GlyCompareCT with one line of code to obtain

Externí odkaz: https://doaj.org/article/0c1ce89d9d2a4bf49a6cf9e4522100a0

Vascular Proteome Responses Precede Organ Dysfunction in a Murine Model of Staphylococcus aureus Bacteremia

Autor: James T. Sorrentino, Gregory J. Golden, Claire Morris, Chelsea D. Painter, Victor Nizet, Alexandre Rosa Campos, Jeffrey W. Smith, Christofer Karlsson, Johan Malmström, Nathan E. Lewis, Jeffrey D. Esko, Alejandro Gómez Toledo

Publikováno v: mSystems, Vol 7, Iss 4 (2022)

ABSTRACT Vascular dysfunction and organ failure are two distinct, albeit highly interconnected, clinical outcomes linked to morbidity and mortality in human sepsis. The mechanisms driving vascular and parenchymal damage are dynamic and display signif

Externí odkaz: https://doaj.org/article/7dfffa287d01412680469a2a0ce401c0

A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Autor: Chenguang Liang, Austin W.T. Chiang, Anders H. Hansen, Johnny Arnsdorf, Sanne Schoffelen, James T. Sorrentino, Benjamin P. Kellman, Bokan Bao, Bjørn G. Voldborg, Nathan E. Lewis

Publikováno v: Current Research in Biotechnology, Vol 2, Iss , Pp 22-36 (2020)

Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite the importance of their glycan structures, our limited knowledge of the glycosylation machinery still hinders controllability of this critical quality attribut

Externí odkaz: https://doaj.org/article/b79c6ab39ef84984b515ef1fae17638c

Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis

Autor: Gregory J. Golden, Alejandro Gómez Toledo, Alex Marki, James T. Sorrentino, Claire Morris, Raquel J. Riley, Charlotte Spliid, Qiongyu Chen, Ingrid Cornax, Nathan E. Lewis, Nissi Varki, Dzung Le, Johan Malmström, Christofer Karlsson, Klaus Ley, Victor Nizet, Jeffrey D. Esko

Publikováno v: mBio, Vol 12, Iss 5 (2021)

Vascular glycocalyx remodeling is critical to sepsis pathology, but the glycocalyx components that contribute to this process remain poorly characterized. This article shows that during Staphylococcus aureus

Externí odkaz: https://doaj.org/article/587771f197f24abdb65b991885346424

A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Autor: Johnny Arnsdorf, Chenguang Liang, Bjørn G. Voldborg, Benjamin P. Kellman, Bokan Bao, Anders Holmgaard Hansen, Nathan E. Lewis, James T. Sorrentino, Austin W. T. Chiang, Sanne Schoffelen

Publikováno v: Current Research in Biotechnology, Vol 2, Iss, Pp 22-36 (2020)
Liang, C, Chiang, A W T, Hansen, A H, Arnsdorf, J, Schoffelen, S, Sorrentino, J T, Kellman, B P, Bao, B, Voldborg, B G & Lewis, N E 2020, ' A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering ', Current Research in Biotechnology, vol. 2, pp. 22-36 . https://doi.org/10.1016/j.crbiot.2020.01.001
Curr Res Biotechnol

Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite the importance of their glycan structures, our limited knowledge of the glycosylation machinery still hinders controllability of this critical quality attribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8804b7be972f26057385ebe88f695122
http://www.sciencedirect.com/science/article/pii/S2590262820300010