Practical issues on the application of the GHS classification criteria for germ cell mutagens

Autor: Madoka Nakajima, Takeshi Morita, Makoto Hayashi, Kaoru Morikawa, David Tweats, T. Sofuni, Noriho Tanaka

Publikováno v: Regulatory Toxicology and Pharmacology. 55:52-68

The Globally Harmonized System of Classification and Labeling of Chemicals (GHS) requires classification of chemicals on germ cell mutagenicity. The Japanese government has conducted GHS classification on about 1400 chemicals in a 2-year project (J-G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef548e3f576be54a07bdd1a91893ba05
https://doi.org/10.1016/j.yrtph.2009.06.001

Toxicity Study of a Rubber Antioxidant, Mixture of 2-Mercaptomethylbenzimidazoles, by Repeated Oral Administration to Rats

Autor: Satoshi Kitajima, Makoto Hayashi, Yasushi Kawasaki, Isama K, Y. Ohno, Tsuda M, Yoshihiro Ogawa, Y. Matsushima, Takashi Umemura, Tohru Inoue, Momma J, M Saitoh, R. Hasegawa, T. Sofuni, T. Suzuki, Yuji Kurokawa, K. Sakemi

Publikováno v: Food and Chemical Toxicology. 37:777-787

2-Mercaptobenzimidazole (2-MBI), a rubber antioxidant, is known to exhibit potent antithyroid toxicity in rats and is a candidate as an environmental endocrine disrupter. 2-Mercaptomethylbenzimidazoles (a 1:1 mixture of 4-methyl and 5-methyl isomers,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c3232e75f9c7176963a4c379133e13
https://doi.org/10.1016/s0278-6915(99)00058-7

Regionally-targeted mutagenesis by metabolically-activated steviol: DNA sequence analysis of steviol-induced mutants of guanine phosphoribosyltransferase (gpt) gene of Salmonella typhimurium TM677

Autor: M. Matsui, T. Nohmi, T. Sofuni

Publikováno v: Mutagenesis. 11:565-572

Steviol is the aglycone of stevioside, a non-caloric sugar substitute commonly used in Japan. Steviol strongly induces mutations at the guanine phosphoribosyltransferase gene (gpt) of Salmonella typhimurium TM677 when the metabolic activation system

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https://doi.org/10.1093/mutage/11.6.565

Contents, Vol. 70, 1995

Autor: G.M. Landes, J.M. Bishop, J. Louhimo, M.L. Freeman, S.S. Kakar, K. Sudo, P. Kunapuli, X. Li, M.R.S. Krishnamani, M.E. Curran, H. Hayes, D.C. Ward, K.W. Gripp, R. Iida, L.A. Pérez Jurado, N. Hayashi, M. Amagai, U. Francke, D. Nadano, M.L. Summar, K. Omoe, M. Aronson, H. Nagase, T. Ishida, K. Ohata, S.C. Maric, B. Dutrillaux, F. Apiou, D.F. Callen, D.W. Bell, G. Goubin, Y. Nakamura, E. Takahashi, B. Schlegelberger, P.N. Tsichlis, H. Hameister, C. Van Broeckhoven, J. Kudoh, E.L.D. Mitchell, E. Sierra-Rivera, S.M. Gartler, M. Schertzer, M. Ogawa, J.L. Benovic, H. Mizusawa, H. Sugawara, C.A. Griffin, N.A. Jenkins, S. Shin, H.L. Grimes, C.I. Civin, M. Yerle, S. Hoyer-Fender, K. Chinen, E. Shtivelman, H. Arakawa, L.A. Cannizzaro, K. Kishi, J.M. Varley, L. Pibouin, H. Yasue, F. Bullrich, Y.-J. Chen, J. Lasota, E.P. Cribiu, M.F. Santibanez Koref, G.R.M. White, S.A. Lane, T. Itoh, D.J. Gilbert, Y. Murakami, J.R. Testa, D. Jones, O.A. Jänne, W. Grote, M.L. Yaremko, M. Poetsch, H. Takeshita, E. Kim, T. Yasuda, T. Sofuni, T. Druck, J.M. Delabar, S. Ueda, T. Eki, N. Shimizu, K. Weber-Matthiesen, C.B. Gilks, K. Huebner, C. Le Chalony, D. Small, N.G. Copeland, H. Ishikawa, A. Endo, P. Burfeind, M. Ohki, Y. Lahbib-Mansas, J. Deerberg, Y. Sakaki, M.T. Keating, H. Tanabe, H.D. Webb, E.Y. Cheng, Y. Wang, C.E. Carow, E.W. Jabs, J. Gellin, T. Nishikawa, A. Milatovich, M. Nagata, T. Fujiwara, S. Suwa, S. Minoshima, J.A. Phillips, T. Hashimoto, S. Wood, M. Dasouki, A.L. Hawkins, F. Claro, R. Peoples, A. Crozat, T. Taguchi, M. Banzai, S. Antonarakis, J. Gomez, P. Zweidler-McKay, T. Haaf, C. Mellink, D. Patterson, S. Knuutila, J.D. Neill

Publikováno v: Cytogenetic and Genome Research. 70:I-IV

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https://doi.org/10.1159/000134026

Statistical analysis of data in mutagenicity assays: rodent micronucleus assay

Autor: T Sofuni, Y Sakamoto, I Yoshimura, Makoto Hayashi, S Hashimoto, C Hamada

Publikováno v: Environmental Health Perspectives

To evaluate chemical safety, many kinds of short-term mutagenicity assays are performed together with long-term assays in animals. Rationales and methodology for these assays have been well discussed and documented. No statistical method, however, ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7469d420ab849271768ecc52697ffb1
https://doi.org/10.1289/ehp.94102s149