Zobrazeno 1 - 10
of 231
pro vyhledávání: '"T, Skare"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host innate immune system, including the complement cascade. The Lyme disease spirochete, Borreliella burgdorferi, has evolved numerous outer membrane lipoproteins
Externí odkaz:
https://doaj.org/article/d67ed208be944b309973bd65ccce22db
Publikováno v:
Infectious Diseases and Tropical Medicine, Vol 7 (2021)
Adult patients with new onset polyarthritis may present a diagnostic challenge; differential diagnosis between primarily rheumatic conditions with viral arthritis such as those caused by parvovirus (PV)-B19 is one of the concerns. Infection by PV-B1
Externí odkaz:
https://doaj.org/article/5dc5ff0c8bcf400d9440fa10904f625c
Autor:
Diana N Medina-Pérez, Beau Wager, Erin Troy, Lihui Gao, Steven J Norris, Tao Lin, Linden Hu, Jenny A Hyde, Meghan Lybecker, Jon T Skare
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008423 (2020)
Post-transcriptional regulation via small regulatory RNAs (sRNAs) has been implicated in diverse regulatory processes in bacteria, including virulence. One class of sRNAs, termed trans-acting sRNAs, can affect the stability and/or the translational e
Externí odkaz:
https://doaj.org/article/2cdf6e3a01834ea6ac3c905912d57a5b
Autor:
Ayiesha P. Barnes, Sanjay Khandelwal, Simone Sartoretto, Sooho Myoung, Samuel J. Francis, Grace M. Lee, Lubica Rauova, Douglas B. Cines, Jon T. Skare, Charles E. Booth, Brandon L. Garcia, Gowthami M. Arepally
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2656-2665
Anti-platelet factor 4 (PF4)/heparin immune complexes that cause heparin-induced thrombocytopenia (HIT) activate complement via the classical pathway. Previous studies have shown that the alternative pathway of complement substantially amplifies the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1af7278bda1c148db6da357774b31c0
https://doi.org/10.1111/jth.15856
https://doi.org/10.1111/jth.15856
Autor:
James P Phelan, Aurelie Kern, Meghan E Ramsey, Maureen E Lundt, Bijaya Sharma, Tao Lin, Lihui Gao, Steven J Norris, Jenny A Hyde, Jon T Skare, Linden T Hu
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007644 (2019)
Borrelia burgdorferi, the causative agent of Lyme disease in humans, is maintained in a complex biphasic life cycle, which alternates between tick and vertebrate hosts. To successfully survive and complete its enzootic cycle, B. burgdorferi adapts to
Externí odkaz:
https://doaj.org/article/18e7fc0697334a6d8589c942b6671a42
Publikováno v:
PLoS Pathogens, Vol 15, Iss 3, p e1007659 (2019)
The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we investigated the function of
Externí odkaz:
https://doaj.org/article/00894cf20d844732a71ee2b0c2f1dda7
Autor:
Sourav Roy, Charles E. Booth, Alexandra D. Powell-Pierce, Anna M. Schulz, Jon T. Skare, Brandon L. Garcia
Borrelial pathogens are vector-borne etiological agents of Lyme disease, relapsing fever, andBorrelia miyamotoidisease. These spirochetes each encode several surface-localized lipoproteins that bind to components of the human complement system. BBK32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ce14c877e5491443455394bd97f7cfd
https://doi.org/10.1101/2023.03.01.530473
https://doi.org/10.1101/2023.03.01.530473
Akademický článek
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Autor:
Rhodaba Ebady, Alexandra F. Niddam, Anna E. Boczula, Yae Ram Kim, Nupur Gupta, Tian Tian Tang, Tanya Odisho, Hui Zhi, Craig A. Simmons, Jon T. Skare, Tara J. Moriarty
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2593-2604 (2016)
Systemic dissemination of microbes is critical for progression of many infectious diseases and is associated with most mortality due to bacterial infection. The physical mechanisms mediating a key dissemination step, bacterial association with vascul
Externí odkaz:
https://doaj.org/article/956cee04904949aa809bc808ee87e2ea
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Activation of the classical complement pathway occurs to varying degrees within strains of the Borrelia burgdorferi sensu lato complex, which contain a group of pathogenic spirochetes that cause tick-borne Lyme borreliosis, including the agent of Lym
Externí odkaz:
https://doaj.org/article/a95f3d7483444dda8e32c337995ad87e