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Akademický článek
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Publikováno v:
The Journal of Immunology. 163:4917-4923
Cell adhesion molecules are considered to be pivotal elements required for proper embryo development. The transmembrane glycoprotein CD44, which is expressed in numerous splice variants on the surface of many different cell types and tissues, has bee
Autor:
T Schweighoffer, Y Tanaka, M Tidswell, D J Erle, K J Horgan, G E Luce, A I Lazarovits, D Buck, S Shaw
Publikováno v:
The Journal of Immunology. 151:717-729
Human memory CD4+ T lymphocytes are heterogenous in expression of integrins; one subset has the unexpected phenotype beta 1 low alpha 4 high. We demonstrate that this subset is unique among CD4+ cells in expression of high levels of alpha 4 beta 7, d
Publikováno v:
The Journal of Immunology. 149:4082-4087
Given the importance of adhesion in T cell development, we have undertaken systematic flow cytometric analysis of CD4 T cells to determine relationships between the developmentally regulated marker CD45R0 and adhesion receptors (five VLA integrin cha
Autor:
F. Antoni, E. Schweighoffer, G. Molnar, T. Schweighoffer, Gaspar Banfalvi, A. Apati, K. Lapis
Publikováno v:
Histochemistry. 96:93-97
DNA staining methods based on aspecific interactions with dye molecules have been replaced by an immunofluorescent approach to measure DNA replication. Biotin-11-dUTP was incorporated into permeable thymocytes isolated after emetine or cyclosporin A
Publikováno v:
Gene therapy. 3(9)
It has been postulated that IL-2 secreting cancer vaccines establish antitumor immunity because the cytokine acting in a paracrine fashion would deliver a helper signal directly to the T cells making contact with the modified tumor cells at the site
Publikováno v:
Cytokines and molecular therapy. 2(3)
Cancer vaccines are genetically modified tumor cells that, by cytokine secretion or by expression of costimulatory molecules, are capable of mobilizing the host's immune system to destroy tumor cells. We have used adenovirus-enhanced transferrinfecti
Autor:
E Herbst, Max L. Birnstiel, G. Maass, T. Schweighoffer, M. Berger, Walter Schmidt, Michael Buschle, Kurt Zatloukal
Publikováno v:
International journal of immunopharmacology. 17(2)
We have previously demonstrated the general usefulness of the adenovirus-enhanced transferrinfection (AVET) in the generation of IL-2 producing tumor vaccines. By optimizing different parameters of the transfection protocol we were able to transform
Autor:
T, Schweighoffer, E, Schweighoffer, M, Sviresheva, A, Apati, A, Balogh, I, Csuka, N N, Luat, G, Banfalvi
Publikováno v:
Cellularmolecular biology research. 39(7)
Emetine (33 mg/kg IP) was used as an immunosuppressive agent to inhibit thymic development. The specific and reversible effect of emetine on the macromolecular biosynthesis of thymocytes provided an in vivo model to investigate cellular differentiati