Výsledky vyhledávání

Large-Scale Synthesis of the Glycine Schiff Base Ni(II) Complex Derived from (S)- and (R)-N-(2-Benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)methyl]-2-pyrrolidinecarboxamide

Autor: Jianlin Han, Todd T. Romoff, Andrew B. Palmer, Bernardo G. Ignacio, Hiroyuki Konno, Hiroki Moriwaki, Hidenori Abe, Vadim A. Soloshonok, Noel Mansour, Christopher J. Creighton

Publikováno v: Organic Process Research & Development. 24:294-300

Non-natural, tailor-made amino acids are of crucial importance to the synthesis of bioactive peptides and new chemical entities. Innovative methodology is always needed for the preparation of enant...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d9872fbeb582ccfd7109aca4213f182
https://doi.org/10.1021/acs.oprd.9b00399

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Scale-up Synthesis of (R)- and (S)-N-(2-Benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide Hydrochloride, A Versatile Reagent for the Preparation of Tailor-Made α- and β-Amino Acids in an Enantiomerically Pure Form

Autor: Todd T. Romoff, Toshio Miwa, Hiroki Moriwaki, Christopher J. Creighton, Noel Mansour, Vadim A. Soloshonok, Andrew B. Palmer, Yuki Ejima

Publikováno v: Organic Process Research & Development. 21:732-739

Unusual amino acids are of crucial importance to the synthesis of bioactive peptides and new chemical entities. Innovative methodology is always needed for the preparation of enantiomerically pure amino acids that does not rely on tedious resolution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5447e5ad4691a6b34af68868b3be52f8
https://doi.org/10.1021/acs.oprd.7b00055

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Development of Hamari Ligands for Practical Asymmetric Synthesisof Tailor-Made Amino Acids

Autor: Hiroyuki Konno, Hiroki Moriwaki, Jianlin Han, Todd T. Romoff, Vadim A. Soloshonok

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
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ACS Omega, Vol 4, Iss 21, Pp 18942-18947 (2019)
ACS Omega

Enantiomerically pure tailor-made amino acids are in extremely high demand in nearly every sector of the health-related industries. In particular, the rapidly growing number of amino-acid-based pharmaceuticals calls for the development of advanced sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a9ac18c5f0018bcbbb4cf797d4c8e1
http://hdl.handle.net/10810/41863

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Urethane-protected N-carboxyanhydrides (UNCAs) as unique reactants for the study of intrinsic racemization tendencies in peptide synthesis

Autor: T T, Romoff, T A, Tran, M, Goodman

Publikováno v: The Journal of Peptide Research. 49:281-292

We have established that urethane-protected N-carboxyanhydrides (UNCAs) are uniquely suited for the study of intrinsic racemization tendencies in peptide synthesis. The UNCA allows epimerization only by the direct enolization pathway (Proton abstract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbb24de7fc670b386f6ffd7d29b890d
https://doi.org/10.1111/j.1399-3011.1997.tb01128.x

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5,5-Dimethylthiazolidine-4-carboxylic acid (DTC) as a proline analog with restricted conformation

Autor: John W. Bean, D. Regoli, D. S. Eggleston, J. Samanen, T. Romoff, G. Zuber, M. Saunders, K. Kopple

Publikováno v: International Journal of Peptide and Protein Research. 35:501-509

Spectroscopic evidence is presented for the lack of intramolecular hydrogen bonding in a simple peptide derivative of 5,5-dimethylthiazolidine-4-carboxylic acid (Dtc). The infrared spectrum of Boc-Pro-Ile-OMe 1 in nonpolar solvents displays two N-H s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb82b240fdb3df0a444673642c1c8c50
https://doi.org/10.1111/j.1399-3011.1990.tb00254.x

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Akademický článek

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3-(Diethoxyphosphoryloxy)-1,2,3- benzotriazin-4(3H)-one (DEPBT): A New Coupling Reagent with Remarkable Resistance to Racemization

Autor: Yun-hua Ye, Murray Goodman, Haitao Li, Chongxu Fan, Xiaohui Jiang, Todd T. Romoff

Publikováno v: Organic Letters. 1:91-94

[formula: see text] The new crystalline phosphate reagent 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT) mediates amide bond formation with a remarkable resistance to racemization. Comparative racemization studies were carried out and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8a06fbada171f7a72209e6f050693f
https://doi.org/10.1021/ol990573k

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