Study design of a phase 4, real-world study (COMPOSUR) to evaluate vibegron in patients with overactive bladder

Autor: Roger R. Dmochowski, Eric S. Rovner, Michael J. Kennelly, Diane K. Newman, Laleh Abedinzadeh, Daniel Snyder, Elizabeth Thomas, Cornelia Haag-Molkenteller, Matt T. Rosenberg

Publikováno v: BMC Urology, Vol 23, Iss 1, Pp 1-7 (2023)

Abstract Background Overactive bladder (OAB) is defined as urinary urgency accompanied by frequency and nocturia, with or without urge urinary incontinence (UUI). Vibegron, a selective β3-adrenergic receptor agonist approved in the US in December 20

Externí odkaz: https://doaj.org/article/711a67b9010f4f20bebd247731097445

Lower Paleolithic Winds of Change: Prepared Core Technologies and the Onset of the Levallois Method in the Levantine Late Acheulian

Autor: T. Rosenberg-Yefet, M. Shemer, R. Barkai

Publikováno v: Frontiers in Earth Science, Vol 10 (2022)

The life cycle of a successful technological innovation usually follows a well-known path: a slow inception, gradual assimilation of the technology, an increase in its frequency up to a certain peak, and then a decline. These different phases are cha

Externí odkaz: https://doaj.org/article/04a4100060f34def8c34f3663984fd4d

A natural history study to track brain and spinal cord changes in individuals with Friedreich's ataxia: TRACK-FA study protocol.

Autor: Nellie Georgiou-Karistianis, Louise A Corben, Kathrin Reetz, Isaac M Adanyeguh, Manuela Corti, Dinesh K Deelchand, Martin B Delatycki, Imis Dogan, Rebecca Evans, Jennifer Farmer, Marcondes C França, William Gaetz, Ian H Harding, Karen S Harris, Steven Hersch, Richard Joules, James J Joers, Michelle L Krishnan, Michelle Lax, Eric F Lock, David Lynch, Thomas Mareci, Sahan Muthuhetti Gamage, Massimo Pandolfo, Marina Papoutsi, Thiago J R Rezende, Timothy P L Roberts, Jens T Rosenberg, Sandro Romanzetti, Jörg B Schulz, Traci Schilling, Adam J Schwarz, Sub Subramony, Bert Yao, Stephen Zicha, Christophe Lenglet, Pierre-Gilles Henry

Publikováno v: PLoS ONE, Vol 17, Iss 11, p e0269649 (2022)

IntroductionDrug development for neurodegenerative diseases such as Friedreich's ataxia (FRDA) is limited by a lack of validated, sensitive biomarkers of pharmacodynamic response in affected tissue and disease progression. Studies employing neuroimag

Externí odkaz: https://doaj.org/article/13b6892396fd4fd9b5968cce8f1724fb

Frequency drift in MR spectroscopy at 3T

Autor: Steve C.N. Hui, Mark Mikkelsen, Helge J. Zöllner, Vishwadeep Ahluwalia, Sarael Alcauter, Laima Baltusis, Deborah A. Barany, Laura R. Barlow, Robert Becker, Jeffrey I. Berman, Adam Berrington, Pallab K. Bhattacharyya, Jakob Udby Blicher, Wolfgang Bogner, Mark S. Brown, Vince D. Calhoun, Ryan Castillo, Kim M. Cecil, Yeo Bi Choi, Winnie C.W. Chu, William T. Clarke, Alexander R. Craven, Koen Cuypers, Michael Dacko, Camilo de la Fuente-Sandoval, Patricia Desmond, Aleksandra Domagalik, Julien Dumont, Niall W. Duncan, Ulrike Dydak, Katherine Dyke, David A. Edmondson, Gabriele Ende, Lars Ersland, C. John Evans, Alan S.R. Fermin, Antonio Ferretti, Ariane Fillmer, Tao Gong, Ian Greenhouse, James T. Grist, Meng Gu, Ashley D. Harris, Katarzyna Hat, Stefanie Heba, Eva Heckova, John P. Hegarty, II, Kirstin-Friederike Heise, Shiori Honda, Aaron Jacobson, Jacobus F.A. Jansen, Christopher W. Jenkins, Stephen J. Johnston, Christoph Juchem, Alayar Kangarlu, Adam B. Kerr, Karl Landheer, Thomas Lange, Phil Lee, Swati Rane Levendovszky, Catherine Limperopoulos, Feng Liu, William Lloyd, David J. Lythgoe, Maro G. Machizawa, Erin L. MacMillan, Richard J. Maddock, Andrei V. Manzhurtsev, María L. Martinez-Gudino, Jack J. Miller, Heline Mirzakhanian, Marta Moreno-Ortega, Paul G. Mullins, Shinichiro Nakajima, Jamie Near, Ralph Noeske, Wibeke Nordhøy, Georg Oeltzschner, Raul Osorio-Duran, Maria C.G. Otaduy, Erick H. Pasaye, Ronald Peeters, Scott J. Peltier, Ulrich Pilatus, Nenad Polomac, Eric C. Porges, Subechhya Pradhan, James Joseph Prisciandaro, Nicolaas A Puts, Caroline D. Rae, Francisco Reyes-Madrigal, Timothy P.L. Roberts, Caroline E. Robertson, Jens T. Rosenberg, Diana-Georgiana Rotaru, Ruth L O'Gorman Tuura, Muhammad G. Saleh, Kristian Sandberg, Ryan Sangill, Keith Schembri, Anouk Schrantee, Natalia A. Semenova, Debra Singel, Rouslan Sitnikov, Jolinda Smith, Yulu Song, Craig Stark, Diederick Stoffers, Stephan P. Swinnen, Rongwen Tain, Costin Tanase, Sofie Tapper, Martin Tegenthoff, Thomas Thiel, Marc Thioux, Peter Truong, Pim van Dijk, Nolan Vella, Rishma Vidyasagar, Andrej Vovk, Guangbin Wang, Lars T. Westlye, Timothy K. Wilbur, William R. Willoughby, Martin Wilson, Hans-Jörg Wittsack, Adam J. Woods, Yen-Chien Wu, Junqian Xu, Maria Yanez Lopez, David K.W. Yeung, Qun Zhao, Xiaopeng Zhou, Gasper Zupan, Richard A.E. Edden

Publikováno v: NeuroImage, Vol 241, Iss , Pp 118430- (2021)

Purpose: Heating of gradient coils and passive shim components is a common cause of instability in the B0 field, especially when gradient intensive sequences are used. The aim of the study was to set a benchmark for typical drift encountered during M

Externí odkaz: https://doaj.org/article/48f8d08362cc4df585976e00c9c0c63f

Quantification approaches for magnetic resonance imaging following intravenous gadolinium injection: A window into brain‐wide glymphatic function

Autor: Sutton B. Richmond, Swati Rane, Moriah R. Hanson, Mehmet Albayram, Jeffrey J. Iliff, Dawn Kernagis, Jens T. Rosenberg, Rachael D. Seidler

Publikováno v: European Journal of Neuroscience. 57:1689-1704

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f85585bd36942c595dc4605f21c5216e
https://doi.org/10.1111/ejn.15974