Zobrazeno 1 - 10
of 2 015
pro vyhledávání: '"T, Pu"'
Autor:
Maksymilian Prondzynski, Paul Berkson, Michael A. Trembley, Yashasvi Tharani, Kevin Shani, Raul H. Bortolin, Mason E. Sweat, Joshua Mayourian, Dogacan Yucel, Albert M. Cordoves, Beatrice Gabbin, Cuilan Hou, Nnaemeka J. Anyanwu, Farina Nawar, Justin Cotton, Joseph Milosh, David Walker, Yan Zhang, Fujian Lu, Xujie Liu, Kevin Kit Parker, Vassilios J. Bezzerides, William T. Pu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac disease modeling and regeneration. Challenges with quality, inter-batch consistency, cryopreservation and scale remain, reducing experimental reproducibility an
Externí odkaz:
https://doaj.org/article/2c3c411f4998447e802af8965f170ea9
Publikováno v:
Cells, Vol 13, Iss 16, p 1342 (2024)
From birth to adulthood, the mammalian heart grows primarily through increasing cardiomyocyte (CM) size, which is known as maturational hypertrophic growth. The Hippo-YAP signaling pathway is well known for regulating heart development and regenerati
Externí odkaz:
https://doaj.org/article/ca044dfa2e164160ab1bedc2fc8cce88
Autor:
Mengmeng Huang, Alexander A. Akerberg, Xiaoran Zhang, Haejin Yoon, Shakchhi Joshi, Celia Hallinan, Christopher Nguyen, William T. Pu, Marcia C. Haigis, C. Geoffrey Burns, Caroline E. Burns
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The developmental mechanisms responsible for the structural defects observed in hypoplastic left heart syndrome remain controversial. Using rbfox-deficient zebrafish, the authors implicate impaired cardiac function as a primary driver of disease.
Externí odkaz:
https://doaj.org/article/9041cd9ac3304895ad0d0487ddc58fc6
Autor:
Fujian Lu, Qing Ma, Wenjun Xie, Carter L. Liou, Donghui Zhang, Mason E. Sweat, Blake D. Jardin, Francisco J. Naya, Yuxuan Guo, Heping Cheng, William T. Pu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Heart muscle cells exhibit exquisitely organized subcellular features that enable efficient and coordinated heart muscle contraction, but little is known about how it is achieved. Here the authors show that CMYA5 organizes cardiomyocyte calcium relea
Externí odkaz:
https://doaj.org/article/e12393a3286b484db96f093687dad036
Publikováno v:
Health Science Reports, Vol 5, Iss 5, Pp n/a-n/a (2022)
Abstract Background In 2014, Mass General Brigham, formerly Partners HealthCare, launched a novel urgent home‐based medical care program to provide rapid medical evaluation and treatment to homebound patients and older adults with frailty or limite
Externí odkaz:
https://doaj.org/article/8c5c88352d7d4384803f54ea9aea23d0
Autor:
Haipeng Guo, Yao Wei Lu, Zhiqiang Lin, Zhan-Peng Huang, Jianming Liu, Yi Wang, Hee Young Seok, Xiaoyun Hu, Qing Ma, Kathryn Li, Jan Kyselovic, Qingchuan Wang, Jenny L.-C. Lin, Jim J.-C. Lin, Douglas B. Cowan, Francisco Naya, Yuguo Chen, William T. Pu, Da-Zhi Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Intercalated discs ensure mechanical and electrochemical coupling during contraction of the heart. Here, the authors show that loss of Xinβ results in cardiomyocyte proliferation defects and cardiomyopathy by influencing the Hippo-YAP signalling pat
Externí odkaz:
https://doaj.org/article/8da0d02d7d2444b1832b1613e9583e1a
Autor:
Youchen Yan, Tianxin Long, Qiao Su, Yi Wang, Ken Chen, Tiqun Yang, Guangyin Zhao, Qing Ma, Xiaoyun Hu, Chen Liu, Xinxue Liao, Wang Min, Shujuan Li, Dihua Zhang, Yuedong Yang, William T. Pu, Yugang Dong, Da-Zhi Wang, Yili Chen, Zhan-Peng Huang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Heart failure is characterized by the inability of the heart to pump effectively and generate proper blood circulation to meet the body’s needs; it is a devastating condition that affects more than 100 million people globally. In spite of this, lit
Externí odkaz:
https://doaj.org/article/afe00277139d40beb3d55a80158867bf
Autor:
Jasbir Singh Dalal, Kellen Diamond Winden, Catherine Lourdes Salussolia, Maria Sundberg, Achint Singh, Truc Thanh Pham, Pingzhu Zhou, William T Pu, Meghan T Miller, Mustafa Sahin
Publikováno v:
eLife, Vol 10 (2021)
Tuberous sclerosis complex (TSC) is a genetic disorder that is associated with multiple neurological manifestations. Previously, we demonstrated that Tsc1 loss in cerebellar Purkinje cells (PCs) can cause altered social behavior in mice. Here, we per
Externí odkaz:
https://doaj.org/article/787c5ae4190e406a97b983bb6fe7572b
Autor:
Luzi Yang, Zhanzhao Liu, Gonglie Chen, Zhan Chen, Congting Guo, Xiangwen Ji, Qinghua Cui, Yueshen Sun, Xiaomin Hu, Yanjiang Zheng, Yifei Li, Fei Gao, Liang Chen, Pingzhu Zhou, William T. Pu, Yuxuan Guo
Publikováno v:
Circulation; 5/28/2024, Vol. 149 Issue 22, p1778-1771, 4p
Autor:
Brynn N. Akerberg, Fei Gu, Nathan J. VanDusen, Xiaoran Zhang, Rui Dong, Kai Li, Bing Zhang, Bin Zhou, Isha Sethi, Qing Ma, Lauren Wasson, Tong Wen, Jinhua Liu, Kunzhe Dong, Frank L. Conlon, Jiliang Zhou, Guo-Cheng Yuan, Pingzhu Zhou, William T. Pu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Mapping transcription factors (TFs) occupancy is essential for understanding transcriptional programs. Here the authors use biotinylated knockin alleles of key cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to map their genome-wide occup
Externí odkaz:
https://doaj.org/article/f91597d9ab8045b0bc0e2854890b31e1