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Fjord-region Benzo[g]chrysene-11,12-dihydrodiol and Benzo[c]phenanthrene-3,4-dihydrodiol as Substrates for Rat Liver Dihydrodiol Dehydrogenase (AKR1C9): Structural Basis for Stereochemical Preference

Autor: Trevor M. Penning, Carol A. Shultz, Ronald G. Harvey, Dipti Mangal, Ian A. Blair, Nisha T. Palackal

Publikováno v: Chemical Research in Toxicology. 21:668-677

This study demonstrates that benzo[g]chrysene-11,12-dihydrodiol (B[g]C-11,12-dihydrodiol) derived from the fjord-region parent hydrocarbon B[g]C is oxidized by rat AKR1C9 with a k c a t/ K m 100 times greater than that observed with the commonly stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454dff842a8085080520e0afd37ddffb
https://doi.org/10.1021/tx7003695

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Activation of Polycyclic Aromatic Hydrocarbontrans-Dihydrodiol Proximate Carcinogens by Human Aldo-keto Reductase (AKR1C) Enzymes and Their Functional Overexpression in Human Lung Carcinoma (A549) Cells

Autor: Seon Hwa Lee, Ian A. Blair, Ronald G. Harvey, Trevor M. Penning, Nisha T. Palackal

Publikováno v: Journal of Biological Chemistry. 277:24799-24808

Polycyclic aromatic hydrocarbons (PAH) are environmental pollutants and suspected human lung carcinogens. In patients with non-small cell lung carcinoma, differential display shows that aldo-keto reductase (AKR1C) transcripts are dramatically overexp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e180fee223fb4243fda93cc21b3ab8c2
https://doi.org/10.1074/jbc.m112424200

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Human AKR1C Isoforms Oxidize the Potent Proximate Carcinogen 7,12-DMBA-3,4-diol in the Human Lung A549 Carcinoma Cell Line

Autor: Seon Hwa Lee, Ronald G. Harvey, Ian A. Blair, Nisha T. Palackal, Trevor M. Penning

Publikováno v: Polycyclic Aromatic Compounds. 22:801-810

Aldo-keto reductases (AKRs) oxidize structurally diverse PAH trans -dihydrodiols to yield reactive and redox active o -quinones. This study examined the ability of AKR1C2 and AKR1C4 to oxidize PAH trans -dihydrodiols of the benz[ a ]anthracene series

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9f4ec061b179be847585c37e62e6cac
https://doi.org/10.1080/10406630290103951

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Crystal Structure of Human Type III 3α-Hydroxysteroid Dehydrogenase/Bile Acid Binding Protein Complexed with NADP+ and Ursodeoxycholate

Autor: Nisha T. Palackal, Trevor M. Penning, Mitchell Lewis, Steven Stayrook, Ross H. Albert, Yi Jin

Publikováno v: Biochemistry. 40:10161-10168

The crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase (HSD)/bile acid binding protein (AKR1C2) complexed with NADP(+) and 3alpha,7beta-dihydroxy-5beta-cholanic acid (ursodeoxycholate) at 3.0 A resolution is presented. Thus, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4b8fbb6b2bd0906b46a4ae32503a17
https://doi.org/10.1021/bi010919a

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Polycyclic Aromatic HydrocarbonTrans-Dihydrodiol Specificity of four Recombinant Human Dihydrodiol Dehydrogenase Isoforms

Autor: Trevor M. Penning, Nisha T. Palackal, Ronald G. Harvey, Michael E. Burczynski

Publikováno v: Polycyclic Aromatic Compounds. 16:205-214

A major metabolic route of polycyclic aromatic hydrocarbon (PAH) activation proceeds through trans-dihydrodiol intermediates. We have previously shown that a member of the aldo-keto reductase (AKR) superfamily, rat liver dihydrodiol dehydrogenase (DD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::521fb0a669382c80630ede34a321d221
https://doi.org/10.1080/10406639908020587

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Laminar Analysis of the Number of Neurons, Astrocytes, Oligodendrocytes and Microglia in the Visual Cortex (Area 17) of 3-Month-Old Rhesus Monkeys Fed a Human Infant Soy-Protein Formula with or without Taurine Supplementation from Birth

Autor: T, Palackal, M, Kujawa, R, Moretz, M, Neuringer, J, Sturman

Publikováno v: Developmental Neuroscience. 13:20-33

The effect of taurine addition to a commercial (taurine-free) soy-protein formula on the development of the visual cortex has been examined in 3-month-old rhesus monkeys. The thickness, number of neurons, astrocytes, oligodendrocytes and microglia ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dea108c51ebb73a9cceded7269041db
https://doi.org/10.1159/000112137

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Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart

Autor: Leonard G. Meggs, Giorgio Olivetti, T Palackal, J. M. Capasso, E. H. Sonnenblick, Piero Anversa

Publikováno v: Circulation Research. 67:871-885

To determine the effects of age on the myocardium, the functional and structural characteristics of the heart were studied in rats at 4, 12, 20, and 29 months of age. Mean arterial pressure, left ventricular pressure and its first derivative (dP/dt),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d3505a975244adf07f7c73f5fb5fad
https://doi.org/10.1161/01.res.67.4.871

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The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation

Autor: Nisha T. Palackal, Ronald G. Harvey, Trevor M. Penning, Michael E. Burczynski

Publikováno v: Biochemistry. 40(36)

Polycyclic aromatic hydrocarbons (PAHs) are metabolized to trans-dihydrodiol proximate carcinogens by human epoxide hydrolase (EH) and CYP1A1. Human dihydrodiol dehydrogenase isoforms (AKR1C1-AKR1C4), members of the aldo-keto reductase (AKR) superfam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8e28237ddb06c8d6cf6866265ead42
https://pubmed.ncbi.nlm.nih.gov/11535067

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