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pro vyhledávání: '"T, Oinonen"'
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Publikováno v:
Cell Biology and Toxicology. 13:257-262
Within the liver acinus the majority of genes are expressed in an ascending or descending gradient from the portal to the central vein. The regulatory factors involved in this spatial pattern of gene expression are still poorly understood. Many liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2728b9b97f388c1c09212a586690e551
https://doi.org/10.1023/a:1007479223229
https://doi.org/10.1023/a:1007479223229
Publikováno v:
Biochemical Journal. 282:635-638
The expression and induction of the cytochrome P450 2B1/2 isoenzyme is heterogeneous, exhibiting a regional pattern in the intact liver and a varied response to phenobarbital in isolated cultured hepatocytes. We report that P450 2B1/2 immunostaining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5487b6faad4efffb6fe41feac349141d
https://doi.org/10.1042/bj2820635
https://doi.org/10.1042/bj2820635
Publikováno v:
Alcoholism, clinical and experimental research. 21(8)
Gut-derived endotoxins (lipopolysaccharide, LPS) are believed to contribute to alcohol-induced liver disease (ALD) by stimulating Kupffer cells, the resident liver macrophages, to release proinflammatory cytokines. This activation is largely mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c945691e664c338a2b0c493ab575b2c
https://pubmed.ncbi.nlm.nih.gov/9394130
https://pubmed.ncbi.nlm.nih.gov/9394130
Publikováno v:
Cell biology and toxicology. 13(4-5)
Within the liver acinus the majority of genes are expressed in an ascending or descending gradient from the portal to the central vein. The regulatory factors involved in this spatial pattern of gene expression are still poorly understood. Many liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a135d7505d23fc4550f5cf32e3b5ae3
https://pubmed.ncbi.nlm.nih.gov/9298246
https://pubmed.ncbi.nlm.nih.gov/9298246
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(1)
The aryl hydrocarbon receptor (AHR) is a transcriptional activator of genes encoding a group of drug-metabolizing enzymes, including cytochrome P450 1A1 (CYP1A1), glutathione S-transferase, tumor-associated aldehyde dehydrogenase and quinone reductas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2d4ce5939291c33e57afd03ca281b49
https://pubmed.ncbi.nlm.nih.gov/8996235
https://pubmed.ncbi.nlm.nih.gov/8996235
Publikováno v:
Pharmacologytoxicology. 79(2)
Regional differences in vulnerability to xenobiotic liver damage may relate to the distribution of the detoxication capacity of the glutathione S-transferases (GST). HPLC analysis of cell lysates obtained by digitonin infusion from either the peripor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ee24bb74455c33af6d3f254ac68060
https://pubmed.ncbi.nlm.nih.gov/8878250
https://pubmed.ncbi.nlm.nih.gov/8878250
Publikováno v:
Biochemical pharmacology. 51(10)
The effect of hypophysectomy and subsequent infusion of growth hormone (GH) or injections of triiodothyronine (T3) on the acinar expression pattern of four homonally regulated P450 isozymes was studied to elucidate the involvement of pituitary depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17bbef990ac37c5c9b7189cca5726945
https://pubmed.ncbi.nlm.nih.gov/8787555
https://pubmed.ncbi.nlm.nih.gov/8787555
Autor:
K O Lindros, T Oinonen
Publikováno v:
The Biochemical journal. 309
Most cytochrome P-450 enzymes are expressed characteristically in a zonated pattern in the liver. The factors responsible for this heterogenous expression are largely unknown. Here we report how growth hormone and tri-iodothyronine regulate the stero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff925dad5648bf5a5d72e345b701959
https://pubmed.ncbi.nlm.nih.gov/7619082
https://pubmed.ncbi.nlm.nih.gov/7619082
Publikováno v:
FEBS letters. 327(2)
The CYP2B1/2 gene pair is an example of many liver genes that exhibit a characteristic zonated expression pattern in the liver. The factors governing this zonation are poorly understood. We observed that after hypophysectomy the expression of CYP2B1/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a4da5bafbb29cbf574099b4c8e685f
https://pubmed.ncbi.nlm.nih.gov/8335114
https://pubmed.ncbi.nlm.nih.gov/8335114