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Akademický článek

Low levels of HIV-1 drug resistance mutations in patients who achieved viral re-suppression without regimen switch: a retrospective study

Publikováno v: BMC Microbiology, Vol 20, Iss 1, Pp 1-9 (2020)

Abstract Background We identified a HIV-positive cohort in virologic failure (VF) who re-suppressed without drug switch. We characterized their drug resistance mutations (DRM) and adherence profiles to learn how to better manage HIV drug resistance.

Externí odkaz: https://doaj.org/article/118b0b6f19f94bab8f3eacfd196ef5cf

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Akademický článek

The role of point-of-care viral load monitoring in achieving the target of 90% suppression in HIV-infected patients in Nigeria: study protocol for a randomized controlled trial

Autor: Seema T. Meloni, Oche Agbaji, Charlotte A. Chang, Patricia Agaba, Godwin Imade, Stephen Oguche, Ahmed Mukhtar, Kiren Mitruka, Mackenzie Hurlston Cox, Aaron Zee, Phyllis Kanki

Publikováno v: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-11 (2019)

Abstract Background The Joint United Nations Programme on HIV/AIDS 90–90-90 goal envisions 90% of all people receiving antiretroviral therapy to be virally suppressed by 2020. Implied in that goal is that viral load be quantified for all patients r

Externí odkaz: https://doaj.org/article/5f2d946259414684b74f4537161071a2

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Akademický článek

Longitudinal evaluation of adherence, retention, and transition patterns of adolescents living with HIV in Nigeria.

Autor: Seema T Meloni, Patricia Agaba, Charlotte A Chang, Esther Yiltok, Stephen Oguche, Emeka Ejeliogu, Oche Agbaji, Prosper Okonkwo, Phyllis J Kanki

Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0236801 (2020)

IntroductionAdherence to antiretroviral therapy (ART) and retention in treatment programs are required for successful virologic suppression and treatment outcomes. As the number of adolescents living with HIV continues to increase globally, more info

Externí odkaz: https://doaj.org/article/3c8b6701ecc14c66aeb5ea873ddb0b80

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Akademický článek

Drug resistance patterns following pharmacy stock shortage in Nigerian Antiretroviral Treatment Program

Autor: Seema T. Meloni, Beth Chaplin, John Idoko, Oche Agbaji, Sulaimon Akanmu, Godwin Imade, Prosper Okonkwo, Robert L. Murphy, Phyllis J. Kanki

Publikováno v: AIDS Research and Therapy, Vol 14, Iss 1, Pp 1-7 (2017)

Abstract Background For patients on antiretroviral therapy (ART), treatment interruptions can impact patient outcomes and result in the accumulation of drug resistance mutations leading to virologic failure. There are minimal published data on the im

Externí odkaz: https://doaj.org/article/ece6c487098c475fb130e8fbda44e6e1

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Akademický článek

Small-sized newborn dogs skeletal development: radiologic, morphometric, and histological findings obtained from spontaneously dead animals

Autor: S. C. Modina, M.C. Veronesi, M. Moioli, T. Meloni, G. Lodi, V. Bronzo, M. Di Giancamillo

Publikováno v: BMC Veterinary Research, Vol 13, Iss 1, Pp 1-10 (2017)

Abstract Background Very little is known about neonatal skeletal development in small-sized purebred dogs. In order to improve this knowledge, 27 spontaneously dead puppies belonging to small-sized breeds were enrolled in this study for radiologic, h

Externí odkaz: https://doaj.org/article/1bc2ba52ba1141b6b5cf28577623ca00

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Akademický článek

Long-Term Outcomes on Antiretroviral Therapy in a Large Scale-Up Program in Nigeria.

Autor: Seema T Meloni, Charlotte A Chang, Geoffrey Eisen, Toyin Jolayemi, Bolanle Banigbe, Prosper I Okonkwo, Phyllis J Kanki

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164030 (2016)

While there has been a rapid global scale-up of antiretroviral therapy programs over the past decade, there are limited data on long-term outcomes from large cohorts in resource-constrained settings. Our objective in this evaluation was to measure mu

Externí odkaz: https://doaj.org/article/c6e60b30efc7443abd93f473c0478fc6

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Akademický článek

Building laboratory capacity to support HIV care in Nigeria: Harvard/APIN PEPFAR, 2004–2012

Autor: Donald J. Hamel, Jean-Louis Sankalé, Jay O. Samuels, Abdoulaye D. Sarr, Beth Chaplin, Eke Ofuche, Seema T. Meloni, Prosper Okonkwo, Phyllis J. Kanki

Publikováno v: African Journal of Laboratory Medicine, Vol 4, Iss 1, Pp e1-e10 (2015)

Introduction: From 2004–2012, the Harvard/AIDS Prevention Initiative in Nigeria, funded through the US President’s Emergency Plan for AIDS Relief programme, scaled up HIV care and treatment services in Nigeria. We describe the methodologies and c

Externí odkaz: https://doaj.org/article/180fbae0ffad41b484477591a9e5e51a

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Akademický článek

Accumulation of protease mutations among patients failing second-line antiretroviral therapy and response to salvage therapy in Nigeria.

Autor: Holly E Rawizza, Beth Chaplin, Seema T Meloni, Kristin M Darin, Oluremi Olaitan, Kimberly K Scarsi, Chika K Onwuamah, Rosemary A Audu, Philippe R Chebu, Godwin E Imade, Prosper Okonkwo, Phyllis J Kanki

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73582 (2013)

BackgroundTo date, antiretroviral therapy (ART) guidelines and programs in resource-limited settings (RLS) have focused on 1(st)- and 2(nd)-line (2 L) therapy. As programs approach a decade of implementation, policy regarding access to 3(rd)-line (3

Externí odkaz: https://doaj.org/article/359508ec00814e7bbff3759eaf8d7c24

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The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital

Autor: Prosper Okonkwo, Jay Osi Samuels, Akin Osibogun, Seema T. Meloni, Titilope A Adeyemo, Raph L. Hamers, Kim C. E. Sigaloff, Ann Abiola Ogbenna, Phyllis J. Kanki, Tobias F. Rinke de Wit, Seth C Inzaule, Alani S Akanmu

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0238027 (2020)
PLoS ONE, 15(8 August):e0238027. Public Library of Science
Ogbenna, A A, Meloni, S, Inzaule, S, Hamers, R L, Sigaloff, K, Osibogun, A, Adeyemo, T A, Okonkwo, P, Samuels, J O, Kanki, P J, de Wit, T F R & Akanmu, A S 2020, ' The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital : A longitudinal evaluation ', PLoS ONE, vol. 15, no. 8, e0238027 . https://doi.org/10.1371/journal.pone.0238027, https://doi.org/10.1371/journal.pone.0238027
PLoS ONE
PLoS ONE, 15(8):e0238027. Public Library of Science

Introduction HIV is a highly diverse virus with significant genetic variability which may confer biologic differences that could impact on treatment outcomes. Materials and methods We studied the association between HIV subtypes and immunologic and v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088ada812521d0dd8b1f260d3a990277
https://doi.org/10.1371/journal.pone.0238027

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Low levels of HIV-1 drug resistance mutations in patients who achieved viral re-suppression without regimen switch: a retrospective study

Publikováno v: BMC Microbiology
BMC Microbiology, Vol 20, Iss 1, Pp 1-9 (2020)

Background We identified a HIV-positive cohort in virologic failure (VF) who re-suppressed without drug switch. We characterized their drug resistance mutations (DRM) and adherence profiles to learn how to better manage HIV drug resistance. A retrosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cb56f3ead3554ec386516d952872a2
http://europepmc.org/articles/PMC6971913

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