Zobrazeno 1 - 10
of 68
pro vyhledávání: '"T, McCune"'
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Justin H. Lo, Ashley B. Cavnar, Lauren M. Babb, Nora Francini, Eva F. Gbur, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetics
Externí odkaz:
https://doaj.org/article/a8ad79f8d57c45aeac75fe1a848bd947
Autor:
Somya Aggarwal, Forrest C Walker, James S Weagley, Broc T McCune, Xiaofen Wu, Lawrence A Schriefer, Heyde Makimaa, Dylan Lawrence, Pratyush Sridhar, Megan T Baldridge
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1011961 (2024)
Noroviruses (NoVs) are a leading cause of viral gastroenteritis. Despite global clinical relevance, our understanding of how host factors, such as antiviral cytokines interferons (IFNs), modulate NoV population dynamics is limited. Murine NoV (MNoV)
Externí odkaz:
https://doaj.org/article/156a71645a0f4958af0295641a001002
Autor:
Forrest C Walker, Ebrahim Hassan, Stefan T Peterson, Rachel Rodgers, Lawrence A Schriefer, Cassandra E Thompson, Yuhao Li, Gowri Kalugotla, Carla Blum-Johnston, Dylan Lawrence, Broc T McCune, Vincent R Graziano, Larissa Lushniak, Sanghyun Lee, Alexa N Roth, Stephanie M Karst, Timothy J Nice, Jonathan J Miner, Craig B Wilen, Megan T Baldridge
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009402 (2021)
Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary pote
Externí odkaz:
https://doaj.org/article/90fb07bf8a2e40fb883cfc49c1867b66
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007940 (2019)
Human norovirus (HNoV) is the leading cause of acute gastroenteritis and is spread by fecal shedding that can often persist for weeks to months after the resolution of symptoms. Elimination of persistent viral reservoirs has the potential to prevent
Externí odkaz:
https://doaj.org/article/956f679c75904a8e81afa024f1afe91a
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Ashley B. Cavnar, Justin H. Lo, Lauren M. Babb, Nora Francini, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
bioRxiv
The high potential for therapeutic application of siRNAs to silence traditionally undruggable oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, siRNAs were optimized forin situbinding to albumin through C1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed437d3b4e1884a99c1762f14a4e284b
https://doi.org/10.1101/2023.02.14.528574
https://doi.org/10.1101/2023.02.14.528574
Autor:
Broc T. McCune, Wei Tang, Jia Lu, James B. Eaglesham, Lucy Thorne, Anne E. Mayer, Emily Condiff, Timothy J. Nice, Ian Goodfellow, Andrzej M. Krezel, Herbert W. Virgin
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT The Norovirus genus contains important human pathogens, but the role of host pathways in norovirus replication is largely unknown. Murine noroviruses provide the opportunity to study norovirus replication in cell culture and in small animals
Externí odkaz:
https://doaj.org/article/c14f5cf474dd4ad49e80a9614b687337
Autor:
Prarthana Patil, Katherine A. Russo, Joshua T. McCune, Alonda C. Pollins, Matthew A. Cottam, Bryan R. Dollinger, Carlisle R. DeJulius, Mukesh K. Gupta, Richard D’Arcy, Juan M. Colazo, Fang Yu, Mariah G. Bezold, John R. Martin, Nancy L. Cardwell, Jeffrey M. Davidson, Callie M. Thompson, Adrian Barbul, Alyssa H. Hasty, Scott A. Guelcher, Craig L. Duvall
Publikováno v:
Sci Transl Med
Porous, resorbable biomaterials can serve as temporary scaffolds that support cell infiltration, tissue formation, and remodeling of nonhealing skin wounds. Synthetic biomaterials are less expensive to manufacture than biologic dressings and can achi
Publikováno v:
The Journal of Applied Laboratory Medicine
Background Widespread testing of SARS-CoV-2 has resulted in shortages of collection devices and transport media. We evaluated the stability of flocked swabs inoculated with SARS-CoV-2-containing specimen incubated dry (i.e., without transport medium)
Autor:
Broc T. McCune, Annette Robichaud, Shamus P. Keeler, Natasha M. Kafai, Adam L. Bailey, Richard D. Head, Julie M. Fox, Sharmila Nair, Jinsheng Yu, Michael S. Diamond, Rita E. Chen, Liang I. Kang, James T. Earnest, Sarah Dort, Michael J. Holtzman, Jon H. Ritter, Emma S. Winkler
Publikováno v:
Nature Immunology
Nature immunology
Nature immunology
Although animal models have been evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease phenotypes seen in humans who have been hospitalized. Here, we evaluate transgenic m
Autor:
Prarthana Patil, Joshua T. McCune, Alyssa M. Hasty, Katherine A. Russo, Matthew A. Cottam, Scott A. Guelcher, Bryan R. Dollinger, Adrian Barbul, Mukesh K. Gupta, John R. Martin, Jeffrey M. Davidson, Juan M. Colazo, Alonda C. Pollins, Fang Yu, Callie M Thompson, Craig L. Duvall, Nancy L. Cardwell
Impaired skin healing and progression into chronic wounds is a prevalent and growing medical problem. Porous, resorbable biomaterials can be used as temporary substrates placed into skin defects to support cell infiltration, neo-tissue formation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325ce2b0926d1008703b9720ffe81bbc
https://doi.org/10.1101/2021.05.21.445175
https://doi.org/10.1101/2021.05.21.445175