Zobrazeno 1 - 10
of 814
pro vyhledávání: '"T, Mattila"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Tuberculosis, caused by Mycobacterium tuberculosis, remains an enduring global health challenge due to the limited efficacy of existing treatments. Although much research has focused on immune failure, the role of host macrophage biology in
Externí odkaz:
https://doaj.org/article/6e40e03c3bee4313a407ee41be16194b
Autor:
Timo A Kumpula, Sandra Vorimo, Taneli T Mattila, Luke O'Gorman, Galuh Astuti, Anna Tervasmäki, Susanna Koivuluoma, Tiina M Mattila, Mervi Grip, Robert Winqvist, Outi Kuismin, Jukka Moilanen, Alexander Hoischen, Christian Gilissen, Tuomo Mantere, Katri Pylkäs
Publikováno v:
PLoS Genetics, Vol 19, Iss 8, p e1010889 (2023)
Copy number variants (CNVs) are a major source of genetic variation and can disrupt genes or affect gene dosage. They are known to be causal or underlie predisposition to various diseases. However, the role of CNVs in inherited breast cancer suscepti
Externí odkaz:
https://doaj.org/article/39bcaeff36374f21a232d35722e005e7
Autor:
O. Nevalainen, O. Niemitalo, I. Fer, A. Juntunen, T. Mattila, O. Koskela, J. Kukkamäki, L. Höckerstedt, L. Mäkelä, P. Jarva, L. Heimsch, H. Vekuri, L. Kulmala, Å. Stam, O. Kuusela, S. Gerin, T. Viskari, J. Vira, J. Hyväluoma, J.-P. Tuovinen, A. Lohila, T. Laurila, J. Heinonsalo, T. Aalto, I. Kunttu, J. Liski
Publikováno v:
Geoscientific Instrumentation, Methods and Data Systems, Vol 11, Pp 93-109 (2022)
Better monitoring, reporting, and verification (MRV) of the amount, additionality, and persistence of the sequestered soil carbon is needed to understand the best carbon farming practices for different soils and climate conditions, as well as their a
Externí odkaz:
https://doaj.org/article/00faffe4d8bc4b53aacb904168ead59e
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Granulomas are the hallmark of Mycobacterium tuberculosis (Mtb) infection. Cytokine-mediated signaling can modulate immune function; thus, understanding the cytokine milieu in granulomas is critical for understanding immunity in tuberculosis (TB). In
Externí odkaz:
https://doaj.org/article/fb22f6e3e15246039437151533c53135
Autor:
Nicole L. Grant, Pauline Maiello, Edwin Klein, Philana Ling Lin, H. Jacob Borish, Jaime Tomko, L. James Frye, Alexander G. White, Denise E. Kirschner, Joshua T. Mattila, JoAnne L. Flynn
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110826- (2022)
Summary: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a global health concern, yearly resulting in 10 million new cases of active TB. Immunologic investigation of lung granulomas is essential for understanding host c
Externí odkaz:
https://doaj.org/article/27d79ee8867c4472a720d0e7466b5302
Autor:
Jess A. Millar, J. Russell Butler, Stephanie Evans, Nicole L. Grant, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/bf3567b2577c4e5a9d254f761658596f
Autor:
Caitlin Hult, Joshua T. Mattila, Hannah P. Gideon, Jennifer J. Linderman, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophil infiltration into tuberculous granulomas is often associated with higher bacteria loads and severe disease but the basis for this relationship is not well understood. To better elucidate the connection between neutrophils and pathology in
Externí odkaz:
https://doaj.org/article/ffd382aa6ff94234b3091ff7cd878378
Autor:
Allexa Dow, Preeti Sule, Timothy J O'Donnell, Andrew Burger, Joshua T Mattila, Brandi Antonio, Kevin Vergara, Endrei Marcantonio, L Garry Adams, Nicholas James, Philip G Williams, Jeffrey D Cirillo, Sladjana Prisic
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009570 (2021)
Mycobacterium tuberculosis (Mtb) has complex and dynamic interactions with the human host, and subpopulations of Mtb that emerge during infection can influence disease outcomes. This study implicates zinc ion (Zn2+) availability as a likely driver of
Externí odkaz:
https://doaj.org/article/072271e868704a108cb696146f9d76b9
Autor:
Jess A. Millar, J. Russell Butler, Stephanie Evans, Nicole L. Grant, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Tuberculosis (TB) is a worldwide health problem; successful interventions such as vaccines and treatment require a 2better understanding of the immune response to infection with Mycobacterium tuberculosis (Mtb). In many infectious diseases, pathogen-
Externí odkaz:
https://doaj.org/article/18bc1f958e4442d3b25681c8a9dfda80
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008520 (2020)
Mycobacterium tuberculosis (Mtb) infection causes tuberculosis (TB), a disease characterized by development of granulomas. Granulomas consist of activated immune cells that cluster together to limit bacterial growth and restrict dissemination. Contro
Externí odkaz:
https://doaj.org/article/60ab6422596b4954ab6edd0dbfc5ff1a