Zobrazeno 1 - 10
of 534
pro vyhledávání: '"T, Marty"'
Autor:
Luis F. Schachner, Christopher Mullen, Wilson Phung, Joshua D. Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas J. Agard, Matthieu Masureel, Joshua Gober, Adel M. ElSohly, Rafael Melani, John E. P. Syka, Romain Huguet, Michael T. Marty, Wendy Sandoval
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The heterogeneity inherent in today’s biotherapeutics, especially as a result of heavy glycosylation, can affect a molecule’s safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment,
Externí odkaz:
https://doaj.org/article/1f51a60ae7254824a781e70ff1592428
Publikováno v:
eLife, Vol 12 (2024)
Structural and functional studies of the ATP-binding cassette transporter MsbA have revealed two distinct lipopolysaccharide (LPS) binding sites: one located in the central cavity and the other at a membrane-facing, exterior site. Although these bind
Externí odkaz:
https://doaj.org/article/0eb56b92ad4242ca82726eb840234084
Autor:
Michael D. Sacco, Shaohui Wang, Swamy R. Adapa, Xiujun Zhang, Eric M. Lewandowski, Maura V. Gongora, Dimitra Keramisanou, Zachary D. Atlas, Julia A. Townsend, Jean R. Gatdula, Ryan T. Morgan, Lauren R. Hammond, Michael T. Marty, Jun Wang, Prahathees J. Eswara, Ioannis Gelis, Rays H. Y. Jiang, Xingmin Sun, Yu Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Antibiotics of the β-lactam class inhibit bacterial cell wall synthesis by targeting penicillin-binding proteins (PBPs). Here, Sacco et al. study the four PBPs present in the pathogen C. difficile, revealing unique structural features and shedding l
Externí odkaz:
https://doaj.org/article/ab479e50342c4a208865cf0e9e27f5cd
Autor:
Yong Zi Tan, José Rodrigues, James E. Keener, Ruixiang Blake Zheng, Richard Brunton, Brian Kloss, Sabrina I. Giacometti, Ana L. Rosário, Lei Zhang, Michael Niederweis, Oliver B. Clarke, Todd L. Lowary, Michael T. Marty, Margarida Archer, Clinton S. Potter, Bridget Carragher, Filippo Mancia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase B EmbB involved in mycobacterial cell wall biosynthesis provides insights into the substrate binding and reaction mechanism. Mapping of the ethambutol resistance associated mutati
Externí odkaz:
https://doaj.org/article/eeb46691fab54cb4aea7d475e6b51125
Publikováno v:
Analytical Chemistry. 95:4984-4991
Daptomycin is a cyclic lipopeptide antibiotic that targets the lipid membrane of Gram-positive bacteria. Membrane fluidity and charge can affect daptomycin activity, but its mechanisms are poorly understood because it is challenging to study daptomyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817c79c51ce04c2de5b3d321cfc26b5e
https://doi.org/10.1021/acs.analchem.2c05222
https://doi.org/10.1021/acs.analchem.2c05222
Publikováno v:
Anal Chem
The structure and function of membrane proteins can be significantly impacted by the surrounding lipid environment, but membrane protein-lipid interactions in lipid bilayers are often difficult to study due to their transient and polydisperse nature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab931ef60be6e758ee2992ad0a3be15
https://pubmed.ncbi.nlm.nih.gov/35621361
https://pubmed.ncbi.nlm.nih.gov/35621361
Publikováno v:
Biochemistry
Lipid membranes have recently been implicated in protein misfolding and disease etiology, including for α-synuclein and Parkinson’s Disease. However, it is challenging to study the intersection of protein complex formation, membrane interactions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5728aa66a3ae769b714d5cd9d8a9aada
https://pubmed.ncbi.nlm.nih.gov/35616927
https://pubmed.ncbi.nlm.nih.gov/35616927
Autor:
Luis F. Schachner, Christopher Mullen, Wilson Phung, Joshua D. Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas Agard, Matthieu Masureel, Joshua Gober, Adel ElSohly, John E. P. Syka, Romain Huguet, Michael T. Marty, Wendy Sandoval
Glycosylated biotherapeutics are an emerging class of drugs with high molecular heterogeneity, which can affect their safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment, but existing methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df06bf053a921f4b232ad59ea02b7183
https://doi.org/10.21203/rs.3.rs-2928767/v1
https://doi.org/10.21203/rs.3.rs-2928767/v1
Autor:
Henry M. Sanders, Farzaneh Chalyavi, Caitlyn R. Fields, Marius M. Kostelic, Ming-Hao Li, Daniel P. Raleigh, Martin T. Zanni, Michael T. Marty
Publikováno v:
Journal of the American Society for Mass Spectrometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57d88b5c280d05fcdb5febddfcd27570
https://doi.org/10.1021/jasms.3c00005
https://doi.org/10.1021/jasms.3c00005