Výsledky vyhledávání

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Melphalan sensitivity as a function of progressive metastatic growth in two subpopulations of a mouse mammary tumour

Autor: G. H. Heppner, Fred R. Miller, T. Machemer, B. E. Miller

Publikováno v: British Journal of Cancer

In order to examine in detail the sensitivity to chemotherapy of tumour cells at various organ sites and at various stages of metastasis, we have used a series of cell lines, all selected from sister subpopulations derived from a single mouse mammary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef05192ec3d9f730641101e7a01b547
http://europepmc.org/articles/PMC1968286

Zobrazit plný text záznamu

Adenovirus-mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo

Autor: H, Köck, M P, Harris, S C, Anderson, T, Machemer, W, Hancock, S, Sutjipto, K N, Wills, R J, Gregory, H M, Shepard, M, Westphal, D C, Maneval

Publikováno v: International journal of cancer. 67(6)

Alterations in the p53 tumor-suppressor gene occur in 35-60% of human glioblastomas, and re-introduction of p53 can suppress neoplastic growth. To evaluate the potential for p53 gene therapy of glioblastoma, we have analyzed the response of human gli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b94daeeda6e024af1bcecdab796f71a2
https://pubmed.ncbi.nlm.nih.gov/8824552

Zobrazit plný text záznamu

Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene

Autor: K N, Wills, W M, Huang, M P, Harris, T, Machemer, D C, Maneval, R J, Gregory

Publikováno v: Cancer gene therapy. 2(3)

We have investigated whether adenovirally mediated gene transfer of the herpes simplex thymidine kinase gene to human hepatocellular carcinoma (HCC) cell lines can sensitize these cells to the prodrug ganciclovir and thereby provide a therapeutic opt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05dd43d919d30e4682904d60daabe7d6
https://pubmed.ncbi.nlm.nih.gov/8528962

Zobrazit plný text záznamu

Recombinant human retinoblastoma protein inhibits cancer cell growth

Autor: L C, Pagliaro, D, Antelman, D E, Johnson, T, Machemer, E A, McCulloch, E J, Freireich, S A, Stass, H M, Shepard, D, Maneval, J U, Gutterman

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 6(6)

Aberrant expression of the tumor suppressor gene RB1 is associated with a variety of solid tumors and hematopoietic neoplasms. Certain cancer cell lines in which the protein encoded by RB1 (p110RB) is absent have been reported to show decreased growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c22a6191aaf83640127c576d536d8b0
https://pubmed.ncbi.nlm.nih.gov/7669721

Zobrazit plný text záznamu

Inhibition of tumor cell proliferation in vitro and in vivo by exogenous p110RB, the retinoblastoma tumor suppressor protein

Autor: D, Antelman, T, Machemer, B G, Huyghe, H M, Shepard, D, Maneval, D E, Johnson

Publikováno v: Oncogene. 10(4)

Reconstitution of retinoblastoma gene (RB) deficient tumor cells with RB generally leads to growth suppression in vitro and/or reduced tumorigenicity in nude mice. An alternate approach to gene replacement is the delivery of the RB gene product (p110

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cfb85bb5fb6d2d5fa1a1c26d23800d4f
https://pubmed.ncbi.nlm.nih.gov/7862447

Zobrazit plný text záznamu

Tumor subpopulation interactions affecting melphalan sensitivity in palpable mouse mammary tumors

Autor: B E, Miller, T, Machemer, M, Lehotan, G H, Heppner

Publikováno v: Cancer research. 51(16)

Paired mixtures of melphalan-sensitive and relatively insensitive tumor cell subpopulation lines, originally derived from the same mammary tumor, were injected s.c. into syngeneic mice. When tumors were palpable, the mice were treated with melphalan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8b2d12934daceccfbc1eb83cbcdadef
https://pubmed.ncbi.nlm.nih.gov/1868461

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání