Zobrazeno 1 - 10
of 40
pro vyhledávání: '"T, Lemm"'
Autor:
Tong J. Gan, John T. Lemm
A wide range of conditions can cause nausea and vomiting, making it a common occurrence in the critically ill. A deeper understanding of the pathophysiology of vomiting has led to the emergence of effective anti-emetics, each targeting a specific neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c791e31e71c122ff92c09fd75406ca72
https://doi.org/10.1093/med/9780199600830.003.0181
https://doi.org/10.1093/med/9780199600830.003.0181
Publikováno v:
Protein Science. 7:1039-1045
Lysosomal degradation of ganglioside GM2 by hexosaminidase A requires the presence of a small, non-enzymatic cofactor, the GM2-activator protein (GM2AP). Lack of functional protein leads to the AB variant of GM2-gangliosidosis, a fatal lysosomal stor
Autor:
V H Perry, E Eliott-Smith, David Smith, T D Butters, T Lemm, Raymond A. Dwek, Gabriele Reinkensmeier, Frances M. Platt, Mylvaganam Jeyakumar, K Sandhoff, Mario Cortina-Borja
Publikováno v:
Neurobiology of Disease, Vol 10, Iss 3, Pp 201-210 (2002)
Mouse models of the G(M2) gangliosidoses, Tay-Sachs and Sandhoff disease, are null for the hexosaminidase alpha and beta subunits respectively. The Sandhoff (Hexb-/-) mouse has severe neurological disease and mimics the human infantile onset variant.
Publikováno v:
The Journal of biological chemistry. 276(16)
According to a recent hypothesis, glycosphingolipids originating from the plasma membrane are degraded in the acidic compartments of the cell as components of intraendosomal and intralysosomal vesicles and structures. Since most previous in vitro inv
Local ultrafast optical excitation of electron-hole pairs in disordered semiconductors provides the possibility to observe experimentally interaction-assisted propagation of correlated quantum particles in a disordered environment. In addition to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f2ccfe64f43e66048688363e2ca715
Publikováno v:
European journal of biochemistry. 261(3)
Differential scanning calorimetry (DSC) and film balance measurements were performed to study the interactions of the GalNAcbeta1--4(NeuAcalpha2--3)Galbeta1--4Glc1 --1'Cer (GM2)-activator protein with phospholipid/ganglioside vesicles and monolayers.
Autor:
U, Bierfreund, T, Lemm, A, Hoffmann, G, Uhlhorn-Dierks, R A, Childs, C T, Yuen, T, Feizi, K, Sandhoff
Publikováno v:
Neurochemical research. 24(2)
The interaction between glycosphingolipids and recombinant human GM2-activator was studied in a microwell binding assay. A-series gangliosides like GM3, GM2 and GM1 were strongly bound by the recombinant human GM2 activator. A weak binding was observ
Publikováno v:
Protein science : a publication of the Protein Society. 7(4)
Lysosomal degradation of ganglioside GM2 by hexosaminidase A requires the presence of a small, non-enzymatic cofactor, the GM2-activator protein (GM2AP). Lack of functional protein leads to the AB variant of GM2-gangliosidosis, a fatal lysosomal stor
Publikováno v:
Journal of the American Dietetic Association. 111:A45
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