Výsledky vyhledávání - "T, Lapveteläinen"

Premature Vertebral Endplate Ossification and Mild Disc Degeneration in Mice After Inactivation of One Allele Belonging to the Col2a1 Gene for Type II Collagen

Autor: Mikko J. Lammi, Jyrki Nieminen, Janne Sahlman, Ritva Inkinen, T. Lapveteläinen, Darwin J. Prockop, Kaija Puustjärvi, Heikki J. Helminen, Machiko Arita, Shi-Wu Li, Mika M. Hyttinen, Pirkko Lammi, Teemu Hirvonen

Publikováno v: Spine. 26:2558-2565

Study design Skeletal tissues of mice with an inactivated allele of the Col2a1 gene for Type II collagen ("heterozygous knockout") were studied. Objective To determine whether a heterozygous inactivation of the Col2a1 gene has a role in the etiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a278963819603a8888c659b8ac414e
https://doi.org/10.1097/00007632-200112010-00008

Zobrazit plný text záznamu

Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer

Autor: Darwin J. Prockop, Machiko Arita, Li Sw, Mika M. Hyttinen, Juha Töyräs, Heikki J. Helminen, Lindblom J, Jukka S. Jurvelin, T. Lapveteläinen

Publikováno v: Annals of the Rheumatic Diseases. 60:262-268

OBJECTIVE To evaluate the influence of inactivation of one allele (“heterozygous knockout” or “heterozygous inactivation”) of the type II procollagen gene (Col2a1) on the biomechanical properties and structure of the articular cartilage and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46e3566bf83e650c8c390482603352e
https://doi.org/10.1136/ard.60.3.262

Zobrazit plný text záznamu

Articular cartilage collagen birefringence is altered concurrent with changes in proteoglycan synthesis during dynamic in vitro loading

Autor: Kari Törrönen, I. Kiviranta, Mika M. Hyttinen, J.A. Arokoski, T. Lapveteläinen, Heikki J. Helminen, Jyrki Parkkinen, K. Kiraly

Publikováno v: The Anatomical Record. 251:28-36

Introduction: The articular cartilage collagen network and proteoglycans are subject to changes in deteriorating joint diseases. In this study, we exposed articular cartilage plugs to cyclic loading and investigated the properties of collagen network

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77c9bc254b9b398e39393953a0bca770
https://doi.org/10.1002/(sici)1097-0185(199805)251:1<28::aid-ar6>3.0.co

Zobrazit plný text záznamu

[Untitled]

Autor: Ilkka Kiviranta, László Módis, Helminen Hj, K. Kiraly, Mika M. Hyttinen, Mika A. Elo, T. Lapveteläinen, Jari Arokoski, J. Dobai

Publikováno v: The Histochemical Journal. 29:317-327

To establish an optimal method for analysis of the collagen structures from unstained tissue sections, a computerized image analysis system using a charge coupled device camera coupled to a polarizing light microscope was used. Retardation values of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80292339c199ba9a072d1f59f5b9ceaa
https://doi.org/10.1023/a:1020802631968

Zobrazit plný text záznamu

Decreased birefringence of the superficial zone collagen network in the canine knee (stifle) articular cartilage after long distance running training, detected by quantitative polarised light microscopy

Autor: László Módis, Helminen Hj, P. Takacs, Mika M. Hyttinen, V. Kovanen, T. Lapveteläinen, Jari Arokoski, B. Kosztaczky

Publikováno v: Annals of the Rheumatic Diseases. 55:253-264

OBJECTIVE: To investigate the effects of a one year programme of running training (up to 40 km/day for 15 weeks) on the spatial orientation pattern of collagen and glycosaminoglycans in articular cartilage in different parts of the knee (stifle) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b35bd52d72f307898bbf66defc02a9
https://doi.org/10.1136/ard.55.4.253

Zobrazit plný text záznamu

Safranin O reduces loss of glycosaminoglycans from bovine articular cartilage during histological specimen preparation

Autor: T. Lapveteläinen, Jari Arokoski, Mikko J. Lammi, Heikki J. Helminen, Markku Tammi, Ilkka Kiviranta, K. Kiraly

Publikováno v: The Histochemical Journal. 28:99-107

The ability of Safranin O, added to fixation and decalcification solutions, to prevent the escape of glycosaminoglycans (GAGs) from small cartilage tissue blocks during histological processing of cartilage has been studied. GAGs in the fixatives and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d86f77caf742d536f4e9bedb07a65a9
https://doi.org/10.1007/bf02331414

Zobrazit plný text záznamu

Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone

Autor: R Fässler, Shi-Wu Li, Darwin J. Prockop, K. Kiraly, H.J. Helminen, H Lui, T. Lapveteläinen, Jari Arokoski, A Peltarri, Machiko Arita

Publikováno v: Genes & Development. 9:2821-2830

Homologous recombination in embryonic stem cells was used to prepare transgenic mice with an inactivated Col2a1 gene for collagen II, the major protein component of the extracellular matrix of cartilage. Heterozygous mice had a minimal phenotype. Hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d2c4908b5ef870ac994d0d0cce01ad
https://doi.org/10.1101/gad.9.22.2821

Zobrazit plný text záznamu

Lifelong moderate running training increases the incidence and severity of osteoarthritis in the knee joint of C57BL mice

Autor: P. Halonen, Heikki J. Helminen, T. Nevalainen, T. Lapveteläinen, Jari Arokoski, Mika M. Hyttinen, Jyrki Parkkinen, K. Kiraly

Publikováno v: The Anatomical Record. 242:159-165

Background: Inbred C57BL made mice express a high incidence of spontaneous osteoarthritis of the knee joint at the age of 18 months. We used this strain of mice to find out the effects of life-long, moderate running exercise on the health of articula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::760133e615246c684cfa607574576112
https://doi.org/10.1002/ar.1092420204

Zobrazit plný text záznamu

Disturbed synthesis of type II collagen interferes with rate of bone formation and growth and increases bone resorption in transgenic mice

Autor: Heikki J. Helminen, Hartmut H. Malluche, Teemu Hirvonen, I Arnala, T. Lapveteläinen, Markku Miettinen, Janne Sahlman, Jyrki Nieminen

Publikováno v: Calcified tissue international. 82(3)

Transgenic mice carrying an internally deleted human type II collagen gene (COL2A1) were used to study bone growth and development. This mutation has previously been shown to disturb the development of collagen fibrils in articular cartilage, causing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ae465902ac675a64c45e4402f45285
https://pubmed.ncbi.nlm.nih.gov/18297226

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání