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Akademický článek

(R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages

Autor: Chandra L. Shrestha, Shuzhong Zhang, Benjamin Wisniewski, Stephanie Häfner, Jonathan Elie, Laurent Meijer, Benjamin T. Kopp

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)

Abstract Cystic fibrosis (CF) is characterized by chronic bacterial infections and heightened inflammation. Widespread ineffective antibiotic use has led to increased isolation of drug resistant bacterial strains from respiratory samples. (R)-roscovi

Externí odkaz: https://doaj.org/article/b28faafa018e4d7a8701559c160e0ad9

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Akademický článek

Emerging Concepts in Defective Macrophage Phagocytosis in Cystic Fibrosis

Autor: Devi Jaganathan, Emanuela M. Bruscia, Benjamin T. Kopp

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 14, p 7750 (2022)

Cystic fibrosis (CF) is caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Chronic inflammation and decline in lung function are major reasons for morbidity in CF. Mutant CFTR expressed in phagocytic cells suc

Externí odkaz: https://doaj.org/article/84268c6eac6e453abde5c227203d8742

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Insights into the Stabilization of Interferon Alpha by Two Surfactants Revealed by STD-NMR Spectroscopy

Autor: Hristo L. Svilenov, Katharina T. Kopp, Alexander P. Golovanov, Gerhard Winter, Matja Zalar

Publikováno v: JOURNAL OF PHARMACEUTICAL SCIENCES

Surfactants are commonly used in biopharmaceutical formulations to stabilize proteins against aggregation. However, the choice of a suitable surfactant for a particular protein is decided mostly empirically, and their mechanism of action on molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c38d51496a10eb98b4cef70bd6a127
https://doi.org/10.1016/j.xphs.2022.10.013

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Akademický článek

Consequences of CRISPR-Cas9-Mediated CFTR Knockout in Human Macrophages

Autor: Shuzhong Zhang, Chandra L. Shrestha, Benjamin L. Wisniewski, Hanh Pham, Xucheng Hou, Wenqing Li, Yizhou Dong, Benjamin T. Kopp

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Macrophage dysfunction is fundamentally related to altered immunity in cystic fibrosis (CF). How genetic deficits in the cystic fibrosis transmembrane conductance regulator (CFTR) lead to these defects remains unknown. Rapid advances in genomic editi

Externí odkaz: https://doaj.org/article/e67b7af5b37044f380f2de3aa8a546f2

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Akademický článek

Oral cysteamine as an adjunct treatment in cystic fibrosis pulmonary exacerbations: An exploratory randomized clinical trial.

Autor: Graham Devereux, Danielle Wrolstad, Stephen J Bourke, Cori L Daines, Simon Doe, Ryan Dougherty, Rose Franco, Alastair Innes, Benjamin T Kopp, Jorge Lascano, Daniel Layish, Gordon MacGregor, Lorna Murray, Daniel Peckham, Vincenzina Lucidi, Emma Lovie, Jennifer Robertson, Douglas J Fraser-Pitt, Deborah A O'Neil

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0242945 (2020)

BackgroundEmerging data suggests a possible role for cysteamine as an adjunct treatment for pulmonary exacerbations of cystic fibrosis (CF) that continue to be a major clinical challenge. There are no studies investigating the use of cysteamine in pu

Externí odkaz: https://doaj.org/article/eae90fa4cc0e475e8b1524d66ccc66a6

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Administrative Data Use in National Registry Efforts: Blessing or Curse?

Autor: Nicholas A, Bedard, Jeffrey N, Katz, Elena, Losina, Maame B, Opare-Addo, Paul T, Kopp

Publikováno v: Journal of Bone and Joint Surgery. 104:39-46

"Big data" refers to a growing field of large database research. Administrative data, a subset of big data, includes information from insurance claims, electronic medical records, and registries that can be useful for investigating novel research que

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8021768afb174c9a6972645f147cd2
https://doi.org/10.2106/jbjs.22.00565

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