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pro vyhledávání: '"T, Klabunde"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 6:365-372
Technosphere insulin (TI), an inhaled insulin with a fast onset of action, provides a novel option for the control of prandial glucose. A euglycemic glucose clamp study was performed to compare the effects of TI and regular human insulin (RHI) on the
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Technosphere insulin (TI), an inhaled insulin with a fast onset of action, provides a novel option for the control of prandial glucose. A euglycemic glucose clamp study was performed to compare the effects of TI and regular human insulin (RHI) on the
Publikováno v:
Biochemistry. 47(16)
Glycogen phosphorylase (GP) is a validated target for the treatment of type 2 diabetes. Here we describe highly potent GP inhibitors, AVE5688, AVE2865, and AVE9423. The first two compounds are optimized members of the acyl urea series. The latter rep
Autor:
T, Klabunde
Publikováno v:
British journal of pharmacology. 152(1)
Paradigms in drug design and discovery are changing at a significant pace. Concomitant to the sequencing of over 180 several genomes, the high-throughput miniaturization of chemical synthesis and biological evaluation of a multiple compounds on gene/
Autor:
R. Jäger, T. Klabunde
Publikováno v:
Ernst Schering Research Foundation Workshop ISBN: 9783540278658
G-protein coupled receptors (GPCRs) are promising targets for the discovery of novel drugs. In order to identify novel chemical series, high-throughput screening (HTS) is often complemented by rational chemogenomics lead finding approaches. We have c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cfc1c78d3e6a4e867aa9dee5899f9ae
https://doi.org/10.1007/978-3-540-37635-4_3
https://doi.org/10.1007/978-3-540-37635-4_3
Autor:
T, Klabunde, R, Jäger
Publikováno v:
Ernst Schering Research Foundation workshop. (58)
G-protein coupled receptors (GPCRs) are promising targets for the discovery of novel drugs. In order to identify novel chemical series, high-throughput screening (HTS) is often complemented by rational chemogenomics lead finding approaches. We have c
Akademický článek
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Publikováno v:
Nature structural biology. 7(4)
The human amyloid disorders, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and senile systemic amyloidosis, are caused by insoluble transthyretin (TTR) fibrils, which deposit in the peripheral nerves and heart tissue. Several nonst
Publikováno v:
Nature structural biology. 7(2)
The antigen 85 (ag85) complex, composed of three proteins (ag85A, B and C), is a major protein component of the Mycobacterium tuberculosis cell wall. Each protein possesses a mycolyltransferase activity required for the biogenesis of trehalose dimyco
Autor:
T. Klabunde, N.G. Oikonomakos, D.D. Leonidas, E. Defossa, Magda Kosmopoulou, Evangelia D. Chrysina, I.D. Kostas, K.U. Wendt
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 61:c182-c182