α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Autor: Mervi T. Hyvönen, Maxim Khomutov, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen

Publikováno v: Biomolecules, Vol 11, Iss 5, p 707 (2021)

Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by s

Externí odkaz: https://doaj.org/article/66a0cf312e4d4b3fa15cda2e6acd0860

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Autor: Ida Alexandersson, Nahida Arifen, Firoozeh Salehzadeh, Anders Thorell, Carolina E. Hagberg, Jeremie Boucher, Kirsty L. Spalding, Qian Li, Ping Chen, Niels Krämer, Matthew J. Harms, Carole Knibbe, Shuai Lang, Helena Silva Cascales, Eleni Terezaki, Mervi T. Hyvönen, Myriam Aouadi, Maria Kutschke

Publikováno v: Nature Medicine
Nature Medicine, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
Nature Medicine, Nature Publishing Group, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩

International audience; Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both adipocyte progenitor differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c988f76cf18afe80c100c7135c054e
https://doi.org/10.1038/s41591-021-01501-8

Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine

Autor: M. A. Khomutov, I. M. Ryzhov, Sergey N. Kochetkov, Mervi T. Hyvönen, Tuomo A. Keinänen, Alexander O. Chizhov, A. I. Salikhov, Jouko Vepsäläinen, A. R. Khomutov

Publikováno v: Russian Journal of Bioorganic Chemistry. 46:1061-1066

A simple and practical 10-step synthesis is reported for previously unknown diastereomers of C‑methylated spermine (Spm) analogue, 1,12-diamino-3,10-dimethyl-4,9-diazadodecane (3,10-Me2Spm), starting from commercially available enantiomers of 2-(Bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ec300858521dc2eb7d001b9ebb7ef03
https://doi.org/10.1134/s1068162020060126

Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis

Autor: Alex Azhayev, Tuomo A. Keinänen, Mervi T. Hyvönen, Elena S. Matyugina, Anastasia L. Khandazhinskaya, Maria I. Kharitonova, Konstantinova Im, Vladimir Barai, Katherine L. Seley-Radtke, Sergey N. Kochetkov, Barbara Z. Eletskaya, Ilja V. Fateev, Alex R. Khomutov

Publikováno v: Organicbiomolecular chemistry. 19(34)

Nucleoside analogues have long served as key chemotherapeutic drugs for the treatment of viral infections and cancers. Problems associated with the development of drug resistance have led to a search for the design of nucleosides capable of bypassing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ae17770268059e11cd7279ac794e75
https://pubmed.ncbi.nlm.nih.gov/34198312

Altered phospholipid-apoB-100 interactions and generation of extra membrane material in proteolysis-induced fusion of LDL particles

Autor: Markku O. Pentikäinen, Marja T. Hyvönen, Katariina Öörni, Tiia Hevonoja, Ari Korhonen, Erno M.P. Lehtonen-Smeds, Mika Ala-Korpela, Petri T. Kovanen

Publikováno v: Journal of Lipid Research, Vol 42, Iss 6, Pp 916-922 (2001)

Lipid droplets and membrane material are produced in the extracellular matrix of the arterial intima during atherogenesis. Both in vitro and in vivo experimentation suggests that fusion of modified LDL particles leads to formation of such lipid dropl

Externí odkaz: https://doaj.org/article/7f0369ff9b4743ffaa234b52c9d5c1ad