Zobrazeno 1 - 10
of 1 170
pro vyhledávání: '"T, Hyvönen"'
Autor:
Mervi T. Hyvönen, Olga A. Smirnova, Vladimir A. Mitkevich, Vera L. Tunitskaya, Maxim Khomutov, Dmitry S. Karpov, Sergey P. Korolev, Merja R. Häkkinen, Marko Pietilä, Marina B. Gottikh, Jouko Vepsäläinen, Leena Alhonen, Alexander A. Makarov, Sergey N. Kochetkov, Heather M. Wallace, Tuomo A. Keinänen, Alex R. Khomutov
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4614 (2022)
The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key downregulator of the polyamine pool is the polyamine-inducible protein, antizyme 1 (OAZ1). OAZ1 inhib
Externí odkaz:
https://doaj.org/article/0c564f8e408144a997efe0c60a190534
Publikováno v:
Biomolecules, Vol 11, Iss 5, p 707 (2021)
Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by s
Externí odkaz:
https://doaj.org/article/66a0cf312e4d4b3fa15cda2e6acd0860
Autor:
Mervi T. Hyvönen, Tuomo A. Keinänen, Gulgina K. Nuraeva, Dmitry V. Yanvarev, Maxim Khomutov, Elena N. Khurs, Sergey N. Kochetkov, Jouko Vepsäläinen, Alexander A. Zhgun, Alex R. Khomutov
Publikováno v:
Biomolecules, Vol 10, Iss 3, p 406 (2020)
The biogenic polyamines, spermine, spermidine (Spd) and putrescine (Put) are present at micro-millimolar concentrations in eukaryotic and prokaryotic cells (many prokaryotes have no spermine), participating in the regulation of cellular proliferation
Externí odkaz:
https://doaj.org/article/3e4aa3d21cd8461992044204c7e08e13
Autor:
Ida Alexandersson, Nahida Arifen, Firoozeh Salehzadeh, Anders Thorell, Carolina E. Hagberg, Jeremie Boucher, Kirsty L. Spalding, Qian Li, Ping Chen, Niels Krämer, Matthew J. Harms, Carole Knibbe, Shuai Lang, Helena Silva Cascales, Eleni Terezaki, Mervi T. Hyvönen, Myriam Aouadi, Maria Kutschke
Publikováno v:
Nature Medicine
Nature Medicine, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
Nature Medicine, Nature Publishing Group, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
Nature Medicine, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
Nature Medicine, Nature Publishing Group, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
International audience; Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both adipocyte progenitor differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c988f76cf18afe80c100c7135c054e
https://doi.org/10.1038/s41591-021-01501-8
https://doi.org/10.1038/s41591-021-01501-8
Akademický článek
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Autor:
M. A. Khomutov, I. M. Ryzhov, Sergey N. Kochetkov, Mervi T. Hyvönen, Tuomo A. Keinänen, Alexander O. Chizhov, A. I. Salikhov, Jouko Vepsäläinen, A. R. Khomutov
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:1061-1066
A simple and practical 10-step synthesis is reported for previously unknown diastereomers of C‑methylated spermine (Spm) analogue, 1,12-diamino-3,10-dimethyl-4,9-diazadodecane (3,10-Me2Spm), starting from commercially available enantiomers of 2-(Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ec300858521dc2eb7d001b9ebb7ef03
https://doi.org/10.1134/s1068162020060126
https://doi.org/10.1134/s1068162020060126
Publikováno v:
Plant, Soil and Environment, Vol 59, Iss 7, Pp 309-315 (2013)
Climate change could promote the altitudinal spread of C4 weed species since they can benefit from warmer climate. The effects of altitude and climatic conditions (the sum of temperatures above 5°C and precipitation) on the biomass and seed producti
Externí odkaz:
https://doaj.org/article/d4c4cebf9aa74ac2bbba27f8c01d8e00
Autor:
Markku O. Pentikäinen, Marja T. Hyvönen, Katariina Öörni, Tiia Hevonoja, Ari Korhonen, Erno M.P. Lehtonen-Smeds, Mika Ala-Korpela, Petri T. Kovanen
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 6, Pp 916-922 (2001)
Lipid droplets and membrane material are produced in the extracellular matrix of the arterial intima during atherogenesis. Both in vitro and in vivo experimentation suggests that fusion of modified LDL particles leads to formation of such lipid dropl
Externí odkaz:
https://doaj.org/article/7f0369ff9b4743ffaa234b52c9d5c1ad
Autor:
Alex Azhayev, Tuomo A. Keinänen, Mervi T. Hyvönen, Elena S. Matyugina, Anastasia L. Khandazhinskaya, Maria I. Kharitonova, Konstantinova Im, Vladimir Barai, Katherine L. Seley-Radtke, Sergey N. Kochetkov, Barbara Z. Eletskaya, Ilja V. Fateev, Alex R. Khomutov
Publikováno v:
Organicbiomolecular chemistry. 19(34)
Nucleoside analogues have long served as key chemotherapeutic drugs for the treatment of viral infections and cancers. Problems associated with the development of drug resistance have led to a search for the design of nucleosides capable of bypassing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ae17770268059e11cd7279ac794e75
https://pubmed.ncbi.nlm.nih.gov/34198312
https://pubmed.ncbi.nlm.nih.gov/34198312
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 707, p 707 (2021)
Volume 11
Issue 5
Biomolecules, Vol 11, Iss 707, p 707 (2021)
Volume 11
Issue 5
Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases
the early phase which can be reversed
the early phase which can be reversed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c59e9b62bf0c52093cbdcbc197ac30e
http://europepmc.org/articles/PMC8151227
http://europepmc.org/articles/PMC8151227