Zobrazeno 1 - 10 of 540 pro vyhledávání: '"T, Hobbs"'
1
Akademický článek
Ligand-specific changes in conformational flexibility mediate long-range allostery in the lac repressor
Autor: Anum Glasgow, Helen T. Hobbs, Zion R. Perry, Malcolm L. Wells, Susan Marqusee, Tanja Kortemme
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Biological regulation ubiquitously depends on protein allostery, but the regulatory mechanisms are incompletely understood, especially in proteins that undergo ligand-induced allostery with few structural changes. Here we used hydrogen-deute
Externí odkaz: https://doaj.org/article/ba6d9b9249fd459e87239216ecc307ce
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2
Akademický článek
Social support correlates with glucocorticoid concentrations in wild African elephant orphans
Autor: J. M. Parker, J. L. Brown, N. T. Hobbs, N. P. Boisseau, D. Letitiya, I. Douglas-Hamilton, G. Wittemyer
Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Remaining with the family group may reduce long-term stress effects in orphaned African elephants.
Externí odkaz: https://doaj.org/article/7ec13f5bd5b146a3a89f5eb3d430db37
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3
Akademický článek
Combining adult with pediatric patient data to develop a clinical decision support tool intended for children: leveraging machine learning to model heterogeneity
Autor: Paul Sabharwal, Jillian H. Hurst, Rohit Tejwani, Kevin T. Hobbs, Jonathan C. Routh, Benjamin A. Goldstein
Publikováno v: BMC Medical Informatics and Decision Making, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Clinical decision support (CDS) tools built using adult data do not typically perform well for children. We explored how best to leverage adult data to improve the performance of such tools. This study assesses whether it is bette
Externí odkaz: https://doaj.org/article/1a594642446e4d409a16c56266a1204f
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6
Akademický článek
Responses of migratory amphibians to barrier fencing inform the spacing of road underpasses: a case study with California tiger salamanders (Ambystoma californiense) in Stanford, CA, USA
Autor: Cheryl S. Brehme, Jeff A. Tracey, Brittany A.I. Ewing, Michael T. Hobbs, Alan E. Launer, Tritia A. Matsuda, Esther M. Cole Adelsheim, Robert N. Fisher
Publikováno v: Global Ecology and Conservation, Vol 31, Iss , Pp e01857- (2021)
Migratory amphibians are at high risk of negative impacts when roads intersect their upland and breeding habitats. Road mortality can reduce population abundance, survivorship, breeding, recruitment, and probability of long-term persistence. Increasi
Externí odkaz: https://doaj.org/article/8ba1bde2e72147f185824d1aec745354
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7
Akademický článek
ECO-CollecTF: A Corpus of Annotated Evidence-Based Assertions in Biomedical Manuscripts
Autor: Elizabeth T. Hobbs, Stephen M. Goralski, Ashley Mitchell, Andrew Simpson, Dorjan Leka, Emmanuel Kotey, Matt Sekira, James B. Munro, Suvarna Nadendla, Rebecca Jackson, Aitor Gonzalez-Aguirre, Martin Krallinger, Michelle Giglio, Ivan Erill
Publikováno v: Frontiers in Research Metrics and Analytics, Vol 6 (2021)
Analysis of high-throughput experiments in the life sciences frequently relies upon standardized information about genes, gene products, and other biological entities. To provide this information, expert curators are increasingly relying on text mini
Externí odkaz: https://doaj.org/article/6563012a49b34ad48518e463b4bcd94c
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