Zobrazeno 1 - 10
of 95
pro vyhledávání: '"T, Hasuma"'
Publikováno v:
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. 14(3)
The monoterpene d-limonene inhibit the plasma-membrane associated P21ras expression and the post-translational isoprenylation of P21ras, a mechanism that may contribute to its efficacy in the chemoprevention and therapy of chemically induced rodent c
Autor:
T, Takashima, Y, Fujiwara, T, Watanabe, K, Tominaga, N, Oshitani, K, Higuchi, T, Matsumoto, T, Arakawa, T, Hasuma, Y, Yano, S, Otani
Publikováno v:
Alimentary pharmacologytherapeutics. 16
Ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynthesis, mediates epithelial cell proliferation and plays a critical role in the optimal repair of gastric mucosal damage. Several studies have shown that Helicobacter pylori inh
Publikováno v:
International journal of oncology. 19(3)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, is involved in suppression of growth of several types of tumors such as liposarcoma, breast cancer, prostate cancer, and colon cancer
Publikováno v:
Anticancer research. 21(2A)
The purpose of this study was to investigate the possible molecular mechanisms of the antiproliferative effect induced by protocatechualdehyde (PA, a dihydroxybenzene derivative). The viability of cytotoxic T cells (CfLL-2) stimulated by IL2 was sign
Publikováno v:
International journal of cancer. 92(2)
Breast-cancer cells frequently invade into the skin. However, few reports have described the mechanisms responsible for this invasion. In this study, we investigated the effects of skin fibroblasts on the invasion ability of breast-cancer cells, usin
Autor:
K, Kageyama, R, Yamada, S, Otani, T, Hasuma, T, Yoshimata, C, Seto, Y, Takada, Y, Yamaguchi, H, Kogawa, N, Miwa
Publikováno v:
Anticancer research. 19(5B)
A new derivative of ascorbic acid (AsA), 6-0-palmitoyl-ascorbate 2-0-phosphate (Asc2P6Pal) was developed to enhance the antitumor activity of AsA. When Ehrlich ascites tumor cells were treated with 50 microM Asc2P6Pal at 37 degrees C or 42 degrees C
Publikováno v:
Anticancer research. 17(4A)
Ras proteins must be isoprenylated at a conserved cysteine residue near the carboxyl terminus (Cys-186 in mammalian Ras p21 proteins) in order to extend their biological activity. Previous studies have indicate an intermediate in the mevalonate pathw
Publikováno v:
The Journal of Immunology. 125:2232-2235
The induction of polyclonal antibody production and mitogenic response by purified carrageenan was studied in vitro by using spleen cells. It was shown that kappa-CGN, lambda-CGN, and iota-CGN induced significant responses in mice, hamsters, and rats
Publikováno v:
Cancer research. 44(4)
Carcinogenic doses of 7,12-dimethylbenz(alpha)anthracene (DMBA) failed to induce mammary carcinoma in the rats that have received N6,O2'-dibutyryl cyclic adenosine 3',5'-monophosphate (DBcAMP) (Cancer Res., 43: 2736, 1983). We now report that the ant
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