Zobrazeno 1 - 10
of 2 743
pro vyhledávání: '"T, Handa"'
Autor:
Sayan Ghosh, Ruchi Sharma, Sridhar Bammidi, Victoria Koontz, Mihir Nemani, Meysam Yazdankhah, Katarzyna M. Kedziora, Donna Beer Stolz, Callen T. Wallace, Cheng Yu-Wei, Jonathan Franks, Devika Bose, Peng Shang, Helena M. Ambrosino, James R. Dutton, Zhaohui Geng, Jair Montford, Jiwon Ryu, Dhivyaa Rajasundaram, Stacey Hose, José-Alain Sahel, Rosa Puertollano, Toren Finkel, J. Samuel Zigler, Yuri Sergeev, Simon C. Watkins, Eric S. Goetzman, Deborah A. Ferrington, Miguel Flores-Bellver, Kai Kaarniranta, Akrit Sodhi, Kapil Bharti, James T. Handa, Debasish Sinha
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a crucial role in RPE health via phagocytosis and autophagy, which a
Externí odkaz:
https://doaj.org/article/9a768d2563fb4e4f839cd5a860fabad3
Publikováno v:
Surgery Open Science, Vol 14, Iss , Pp 52-59 (2023)
Background: Currently, surgical education utilizes a combination of the apprentice model, wet-lab training, and simulation, but due to reliance on subjective data, the quality of teaching and assessment can be variable. The “language of surgery,”
Externí odkaz:
https://doaj.org/article/a26bdc0d69564d6f90511562faac3974
Autor:
Haitao Liu, Nadezda A. Stepicheva, Sayan Ghosh, Peng Shang, Olivia Chowdhury, Rachel A. Daley, Meysam Yazdankhah, Urvi Gupta, Stacey L. Hose, Mallika Valapala, Christopher Scott Fitting, Anastasia Strizhakova, Yang Shan, Derrick Feenstra, José-Alain Sahel, Ashwath Jayagopal, James T. Handa, J. Samuel Zigler, Patrice E. Fort, Akrit Sodhi, Debasish Sinha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Retinal pigment epithelium (RPE) plays an important role in diabetic retinopathy (DR) progression. Here, the authors show AKT1 and AKT2 are reciprocally regulated in the RPE of DR donor tissue and diabetic mice, reducing Akt2 in RPE causing a compens
Externí odkaz:
https://doaj.org/article/b6a04d515080449b8de555a71e4835ba
Publikováno v:
Journal of Ophthalmic Inflammation and Infection, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract While socioeconomic disparities impact clinical care and patient outcomes, their impact on the anatomic and visual outcomes of retinal detachment in patients with viral retinitis is unstudied. This case series included 18 eyes in 18 patients
Externí odkaz:
https://doaj.org/article/10df6108edd94c1b8b9ffd72ed4b47a6
Publikováno v:
International Journal of Retina and Vitreous, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract Background The purpose of this study was to evaluate visual acuity after cataract surgery in eyes with Macular Telangiectasia (MacTel) Type 2. Methods Single-center retrospective cohort study of patients with MacTel Type 2 who underwent cata
Externí odkaz:
https://doaj.org/article/5d4bb30dd6cb466da63f90336cdb52a6
Publikováno v:
Ophthalmology Science, Vol 2, Iss 4, Pp 100213- (2022)
Age-related macular degeneration (AMD) is the leading cause of blindness for the elderly in high-income countries. Although multivitamin antioxidant nutrients can slow the progression of intermediate “dry” or nonneovascular AMD, no treatment can
Externí odkaz:
https://doaj.org/article/0d0b4522632844f191c7bf3270283f2f
Publikováno v:
International Journal of Retina and Vitreous, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract Background Degenerative retinoschisis is a common condition defined by the splitting of the neurosensory retina that may rarely be associated with progressive retinal detachment (RD). Here, we aim to describe the anatomic and functional outc
Externí odkaz:
https://doaj.org/article/b15a7416fa17402cb6be58cc04389f89
Autor:
Shahid Y. Khan, Muhammad Ali, Yura Jang, Taekyung Ryu, Andrew J. Schwab, Brian O. Ingram, Peter H. Cable, Chan Hyun Na, James T. Handa, S. Amer Riazuddin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Here, we report a multi OMIC (transcriptome, proteome, and metabolome) approach to investigate molecular changes in lens fiber cells (FC) of mice exposed to cigarette smoke (CS). Pregnant mice were placed in a whole-body smoke chamber and a
Externí odkaz:
https://doaj.org/article/f1063b2da7a34cb194c3953bea43b74f
Autor:
Peng Shang, Nadezda Stepicheva, Kenneth Teel, Austin McCauley, Christopher Scott Fitting, Stacey Hose, Rhonda Grebe, Meysam Yazdankhah, Sayan Ghosh, Haitao Liu, Anastasia Strizhakova, Joseph Weiss, Imran A. Bhutto, Gerard A. Lutty, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, J. Samuel Zigler, James T. Handa, Yuri Sergeev, Raju V. S. Rajala, Simon Watkins, Debasish Sinha
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Shang et al. utilize a conditional Cryba1 knockout mouse model to demonstrate a key role for βA3/A1-crystallin in retinal pigmented epithelium. As a result of βA3/A1-crystallin deficiency, the authors report EGFR endocytosis defects and actin netwo
Externí odkaz:
https://doaj.org/article/601fb7f3dfa3458993f6399da1134e8f
Autor:
Sayan Ghosh, Haitao Liu, Meysam Yazdankhah, Nadezda Stepicheva, Peng Shang, Tanuja Vaidya, Stacey Hose, Urvi Gupta, Michael Joseph Calderon, Ming-Wen Hu, Archana Padmanabhan Nair, Joseph Weiss, Christopher S. Fitting, Imran A. Bhutto, Santosh Gopi Krishna Gadde, Naveen Kumar Naik, Chaitra Jaydev, Gerard A. Lutty, James T. Handa, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, Dhivyaa Rajasundaram, Yuri Sergeev, J. Samuel Zigler, Swaminathan Sethu, Simon Watkins, Arkasubhra Ghosh, Debasish Sinha
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
Ghosh et al. show that a lens protein βA1-crystallin inhibits PTP1B activity, regulating the metabolism of retinal astrocytes. They find that knockdown of βA1-crystallin exacerbates the streptozotocin-induced diabetic retinopathy-like phenotype in
Externí odkaz:
https://doaj.org/article/73f2d2042a5b442cb0991f9ae494dfe7