Zobrazeno 1 - 10
of 708
pro vyhledávání: '"T, Grogan"'
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301394 (2024)
Engineering systems, characterized by their high technical complexity and societal intricacies, require a strategic design approach to navigate multifaceted challenges. Understanding the circumstances that affect strategic action in these systems is
Externí odkaz:
https://doaj.org/article/853fc0a46ee543e893525bf9469489e6
Autor:
Patrick T. Grogan, Jeffrey J. Helgager, Dustin A. Deming, Steven P. Howard, Robert B. Jenkins, H. Ian Robins
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Radiation-induced gliomas (RIGs) are an uncommon disease type and a known long-term complication of prior central nervous system radiation exposure, often during childhood. Given the rarity of this malignancy subtype, no clinical trials have explored
Externí odkaz:
https://doaj.org/article/fd5e022e89164767842b930277235940
Autor:
Chitra Subramanian, Patrick T. Grogan, Ton Wang, Joseph Bazzill, Ang Zuo, Peter T. White, Avinaash Kalidindi, Dawn Kuszynski, Grace Wang, Brian S. J. Blagg, Mark S. Cohen
Publikováno v:
Molecular Oncology, Vol 14, Iss 9, Pp 2058-2068 (2020)
In patients with triple‐negative breast cancer (TNBC), evidence suggests that tumor‐initiating cells (TIC) have stem cell‐like properties, leading to invasion and metastasis. HSP90 plays a critical role in the conformational maintenance of many
Externí odkaz:
https://doaj.org/article/b903ea765283488cbf81ea52f406e330
Publikováno v:
Design Science, Vol 8 (2022)
Robust designs protect system utility in the presence of uncertainty in technical and operational outcomes. Systems-of-systems, which lack centralized managerial control, are vulnerable to strategic uncertainty from coordination failures between part
Externí odkaz:
https://doaj.org/article/8e036bfb6c1a4ac39897f00f03fe4807
Autor:
Paul T. Grogan
Publikováno v:
Design Science, Vol 7 (2021)
This paper draws on perspectives from co-design as an integrative and collaborative design activity and co-simulation as a supporting information system to advance engineering design methods for problems of societal significance. Design and implement
Externí odkaz:
https://doaj.org/article/46f9ef99fdc245d28041113fa541f7f8
Autor:
Paul T. Grogan
Publikováno v:
Data in Brief, Vol 20, Iss , Pp 1079-1084 (2018)
The experiment studies the effect of technical and social sources of complexity on effort required to complete abstracted design tasks. Parameter design tasks define a set of input design parameters and functional requirements modeled with a linear c
Externí odkaz:
https://doaj.org/article/0498226389ed4f1eb8bd39ee800e8f85
Autor:
Jordan L. Stern, Paul T. Grogan
Publikováno v:
Journal of Spacecraft and Rockets. 59:1240-1254
Publikováno v:
Design Science, Vol 5 (2019)
Engineered system architectures leveraging collaboration among multiple actors across organizational boundaries are envisioned to be more flexible, robust, or efficient than independent alternatives but also carry significant downside risks from new
Externí odkaz:
https://doaj.org/article/2f2a5b67c1d74a1c92d089db9166554b
Autor:
Alkım Z. Avşar, Paul T. Grogan
Publikováno v:
Systems Engineering.
Autor:
Josue I. Tapia, Paul T. Grogan
Publikováno v:
2023 IEEE International Systems Conference (SysCon).