Zobrazeno 1 - 10
of 85
pro vyhledávání: '"T, Dyrks"'
Autor:
A.E. Oakley, T. Dyrks, M. Thunecke, Y. Georgalis, W. Saenger, J. Turner, U Kosciessa, A. Lobbia
Publikováno v:
The Journal of Peptide Research. 52:509-517
The aggregation behavior of the major component of Alzheimer's disease-related, amyloid peptides, Abeta-(1-40) and Abeta-(1-42), was studied in solution using dynamic light scattering. With most solvents employed, we found fibrils coexisting with oli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965f51503c6acaae39f91250196af033
https://doi.org/10.1111/j.1399-3011.1998.tb01255.x
https://doi.org/10.1111/j.1399-3011.1998.tb01255.x
Autor:
T. Dyrks, S. Paul, Markus Otto, Hans-Wolfgang Klafki, E. Rüther, M. Maler, Mirko Bibl, Bernhard Schmidt, Jens Wiltfang, Hermann Esselmann, M. Bienert, M. Beyermann, Alexandr F Smirnov, Johannes Kornhuber
Publikováno v:
Journal of Neurochemistry. 81:481-496
Human lumbar CSF patterns of Aβ peptides were analysed by urea-based β-amyloid sodium dodecyl sulphate polyacrylamide gel electrophoresis with western immunoblot (Aβ-SDS–PAGE/immunoblot). A highly conserved pattern of carboxyterminally truncated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce073d2cd44dd03e55429a5a8d10f44a
https://doi.org/10.1046/j.1471-4159.2002.00818.x
https://doi.org/10.1046/j.1471-4159.2002.00818.x
Publikováno v:
Journal of Biological Chemistry. 267:18210-18217
Previously we have shown that the COOH-terminal 100 residues (A4CT) of the amyloid protein precursor (APP), which carry the sequence of the amyloid beta A4 protein of Alzheimer's disease at N-terminal position, form highly insoluble aggregates if exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7985bbd2ed5b43c3a18903a8907a3e3
https://doi.org/10.1016/s0021-9258(19)37174-1
https://doi.org/10.1016/s0021-9258(19)37174-1
Autor:
Andreas Weidemann, Caroline Hilbich, T. Dyrks, Gerd Multhaup, R. Prior, Colin L. Masters, G. König, David H. Small, Baden Rumble, Konrad Beyreuther, Ursula Mönning, Ashley I. Bush, Walter Schubert
Publikováno v:
Annals of the New York Academy of Sciences. 640:129-139
At the cellular level, Alzheimer's disease (AD) must be the result of neuronal dysfunction and degeneration leading to a reduction in synaptic density. Filamentous deposits of amyloid, which define the disease at the molecular level, occur within per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09cbff8a6956617e7a785796566cf9d
https://doi.org/10.1111/j.1749-6632.1991.tb00204.x
https://doi.org/10.1111/j.1749-6632.1991.tb00204.x
Autor:
E. Rüther, H. Esselmann, Sabine Paul, Johannes Kornhuber, Jens Wiltfang, T. Dyrks, M. Fiszer, J. M. Maler, Hans-Wolfgang Klafki, Udo Reulbach, P. Lewczuk
Publikováno v:
Pharmacopsychiatry. 38
Targeting the deposition of β-amyloid into neuritic plaques has been suggested as a pharmacological approach to alter the progression of Alzheimer disease (AD). Some non-steroidal anti-inflammatory drugs (NSAID) were recently shown to specifically i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4d783c1cfb887dbda123eb69406918e
https://doi.org/10.1055/s-2005-918775
https://doi.org/10.1055/s-2005-918775
Autor:
J, Wiltfang, H, Esselmann, M, Bibl, A, Smirnov, M, Otto, S, Paul, B, Schmidt, H-W, Klafki, M, Maler, T, Dyrks, M, Bienert, M, Beyermann, E, Rüther, J, Kornhuber
Publikováno v:
Journal of neurochemistry. 81(3)
Human lumbar CSF patterns of Abeta peptides were analysed by urea-based beta-amyloid sodium dodecyl sulphate polyacrylamide gel electrophoresis with western immunoblot (Abeta-SDS-PAGE/immunoblot). A highly conserved pattern of carboxyterminally trunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54a8dc2d3e1bb17f36f089b207a8ec1b
https://pubmed.ncbi.nlm.nih.gov/12065657
https://pubmed.ncbi.nlm.nih.gov/12065657
Autor:
Gerd Multhaup, Konrad Beyreuther, G. König, T. Dyrks, Colin L. Masters, Peter Pollwein, Walter Schubert, Ursula Mönning
Publikováno v:
Annals of the New York Academy of Sciences. 695
A four- to fivefold overexpression of the gene for the Alzheimer beta/A4 amyloid precursor protein (APP) in individuals with Down's Syndrome (DS) appears to be responsible for the fifty year earlier onset of Alzheimer's disease (AD) pathology in DS c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81407981003b3061a50cea1c3f4a14a
https://pubmed.ncbi.nlm.nih.gov/8239320
https://pubmed.ncbi.nlm.nih.gov/8239320
Publikováno v:
FEBS letters. 309(1)
Previously we have shown that the COOH-terminal fragment (A4CT) of the Alzheimer amyloid protein precursor (APP), which at the NH2-terminus carries the sequence of the amyloid βA4 protein, forms highly insoluble aggregates [EMBO J. (1988) 7, 949–9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb85e33117f9bac8a2d5953f164755df
https://pubmed.ncbi.nlm.nih.gov/1511741
https://pubmed.ncbi.nlm.nih.gov/1511741
Autor:
K, Beyreuther, T, Dyrks, C, Hilbich, U, Mönning, G, König, G, Multhaup, P, Pollwein, C L, Masters
Publikováno v:
Progress in clinical and biological research. 379
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9db1b89ad0eb40c43c6e6729dd1e9a35
https://pubmed.ncbi.nlm.nih.gov/1409743
https://pubmed.ncbi.nlm.nih.gov/1409743
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