Unique transcriptional signatures correlate with behavioral and psychological symptom domains in Alzheimer’s disease

Autor: Daniel W. Fisher, Jeffrey T. Dunn, Rachel Keszycki, Guadalupe Rodriguez, David A. Bennett, Robert S. Wilson, Hongxin Dong

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Despite the significant burden, cost, and worse prognosis of Alzheimer’s disease (AD) with behavioral and psychological symptoms of dementia (BPSD), little is known about the molecular causes of these symptoms. Using antemortem assessments

Externí odkaz: https://doaj.org/article/d84911835c5e413487f397e785a85362

Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT)Research in context

Autor: Nicholas I. Paton, Wolfgang Stöhr, Alejandro Arenas-Pinto, Amanda Clarke, Ian Williams, Margaret Johnson, Chloe Orkin, Fabian Chen, Vincent Lee, Alan Winston, Mark Gompels, Julie Fox, Karen Sanders, David T. Dunn, Martin Fisher, Wendy Hadley, David Stacey, Pat Byrne, Nahum De Esteban, Pierre Pellegrino, Lewis Haddow, James Hand, Carl De Souza, Lisa Murthen, Andrew Crawford-Jones, Ruth Wilson, Elizabeth Green, John Masterson, Kamlesh Patel, Rebecca Howe, Scott Mullaney, Louise Jennings, Nicholas Beeching, Rebecca Tamaklo, Alistair Teague, Isabelle Jendrulek, Juan Manuel Tiraboschi, Ed Wilkins, Yvonne Clowes, Andrew Thompson, Gary Brook, Manoj Trivedi, Kazeem Aderogba, Martin Jones, Andrew DeBurgh-Thomas, Liz Jones, Iain Reeves, Sifiso Mguni, David Chadwick, Pauline Spence, Nellie Nkhoma, Zoe Warwick, Suzanne Price, Sally Read, Elbushra Herieka, James Walker, Ruth Woodward, John Day, Laura Hilton, Veerakathy Harinda, Helen Blackman, Phillip Hay, Wendy Mejewska, Olanike Okolo, Edmund Ong, Karen Martin, Lee Munro, David Dockrell, Lynne Smart, Jonathan Ainsworth, Anele Waters, Stephen Kegg, Sara McNamara, Steve Taylor, Gerry Gilleran, Brian Gazzard, Jane Rowlands, Sris Allan, Rumun Sandhu, Nigel O'Farrell, Sheena Quaid, Fabiola Martin, Caroline Bennett, Moses Kapembwa, Jane Minton, James Calderwood, Frank Post, Lucy Campbell, Emily Wandolo, Adrian Palfreeman, Linda Mashonganyika, Thambiah Balachandran, Memory Kakowa, Rebecca O'Connell, Cheryl Tanawa, Sinna Jebakumar, Lesley Hagger, Say Quah, Sinead McKernan, Charles Lacey, Sarah Douglas, Sarah Russell-Sharpe, Christine Brewer, Clifford Leen, Sheila Morris, Sharmin Obeyesekera, Shirley Williams, Nelson David, Mark Roberts, Julie Wollaston, Nicholas Paton, Karen Scott, David Dunn, Emma Beaumont, Sue Fleck, Mark Hall, Susie Hennings, Ischa Kummeling, Sara Martins, Ellen Owen-Powell, Fionna van Hooff, Livia Vivas, Ellen White, Brian Angus, Andrew Freedman, Ben Cromerty, Danielle Mercey, Sarah Fidler, Estee Torok, Abdel Babiker, Tim Peto, David Lalloo, Andrew Phillips, Robert James

Publikováno v: EClinicalMedicine, Vol 69, Iss , Pp 102457- (2024)

Summary: Background: Treatment-simplification strategies are important tools for patient-centred management. We evaluated long-term outcomes from a PI monotherapy switch strategy. Methods: Eligible participants attending 43 UK treatment centres had a

Externí odkaz: https://doaj.org/article/aefd2413e78d42f29d03d4ab013c1e5b

Interpretation of active-control randomised trials: the case for a new analytical perspective involving averted events

Autor: David T. Dunn, Oliver T. Stirrup, Sheena McCormack, David V. Glidden

Publikováno v: BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-6 (2023)

Abstract Active-control trials, where an experimental treatment is compared with an established treatment, are performed when the inclusion of a placebo control group is deemed to be unethical. For time-to-event outcomes, the primary estimand is usua

Externí odkaz: https://doaj.org/article/64cf68fd6e1745799dce47f7cc3254de

From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

Autor: Cornelia Carey, Nisha Singh, Joel T. Dunn, Teresa Sementa, Maria Andreina Mendez, Hester Velthuis, Andreia C. Pereira, Charlotte Marie Pretzsch, Jamie Horder, Stefan Hader, David J. Lythgoe, Diana-Georgina Rotaru, Anthony Gee, Diana Cash, Mattia Veronese, Declan Murphy, Grainne McAlonan

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E) glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the close functional ties between mGluR5 and E/I signalling, no-on

Externí odkaz: https://doaj.org/article/02d837ef71704930abb2ee1c81fd3c63

Role of 3'-Deoxy-3'-[18F] Fluorothymidine Positron Emission Tomography-Computed Tomography as a Predictive Biomarker in Argininosuccinate Synthetase 1-Deficient Thoracic Cancers Treated With Pegargiminase

Autor: Teresa A. Szyszko, MD, FRCR, Joel T. Dunn, PhD, Melissa M. Phillips, MD, PhD, John Bomalaski, MD, Michael T. Sheaff, MD, Steve Ellis, MD, Lucy Pike, PhD, Vicky Goh, MD, FRCR, Gary J.R. Cook, MD, FRCR, Peter W. Szlosarek, MD, PhD, FRCP

Publikováno v: JTO Clinical and Research Reports, Vol 3, Iss 9, Pp 100382- (2022)

Introduction: Pegargiminase (ADI-PEG 20I) degrades arginine in patients with argininosuccinate synthetase 1-deficient malignant pleural mesothelioma (MPM) and NSCLC. Imaging with proliferation biomarker 3'-deoxy-3'-[18F] fluorothymidine (18F-FLT) pos

Externí odkaz: https://doaj.org/article/24b63e146e99419791c4c911d1a9c802