Výsledky vyhledávání

Investigation of an outbreak of group A Streptococcus in a Regina retirement residence and personal care home, 2018

Autor: C Danielson, M Hennink, K Lloyd, Molly Trecker, C Benz Tramer, G Koutsoulis, T Diener

Publikováno v: Canadian Journal of Infection Control. :175-178

Streptococcus pyogenes (group A Streptococcus) is a common bacterium that causes infections ranging from minor illnesses, like strep throat, to life-threatening invasive disease. The elderly are particularly at risk of invasive infection, with this r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b123e88352b8eda844b9c90ab0a4579
https://doi.org/10.36584/cjic.2019.019

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Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma

Autor: Eunice Yuen, Francesco Ricci, J-C. Soria, Charles Ferté, Caroline Even, J. T. Diener, Karim A. Benhadji, Claire Smith, Jaime R. Merchan, Ulrik Lassen, Christophe Massard, Gerard J. Oakley, C. Le Tourneau

Publikováno v: Even, C, Lassen, U, Merchan, J, Le Tourneau, C, Soria, J C, Ferte, C, Ricci, F, Diener, J T, Yuen, E, Smith, C, Oakley, G J, Benhadji, K A & Massard, C 2020, ' Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma ', Investigational New Drugs, vol. 38, no. 2, pp. 402-409 . https://doi.org/10.1007/s10637-019-00739-x
Investigational New Drugs

Summary Background Deregulated Notch signaling is implicated in multiple cancers. The phase I trial (I6F-MC-JJCA) investigated the safety and anti-tumor activity of crenigacestat (LY3039478), a selective oral Notch inhibitor, in an expansion cohort o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27ae2738b1f51cdb2d398ebbb83c9f5
https://curis.ku.dk/ws/files/249477116/Safety_and_clinical_activity_of_the_Notch_inhibitor_crenigacestat.pdf

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Akademický článek

An Unusual Case of Vaccine-Associated Paralytic Poliomyelitis

Autor: S Desai, T Diener, BJ-K Tan, NJ Lowry, C Talukdar, WM Chrusch, S Wiebe

Publikováno v: Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 25, Iss 4, Pp 227-228 (2014)

The present article reports a case involving an immunocompetent, previously well child who, despite two previous doses of inactivated poliovirus vaccine, developed severe flaccid paralysis consistent with polio after receiving oral polio vaccine.

Externí odkaz: https://doaj.org/article/46ef4f2b19f747bc9490483e6231cb4f

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Akademický článek

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Aripiprazole in Pervasive Developmental Disorder Not Otherwise Specified and Asperger's Disorder: A 14-Week, Prospective, Open-Label Study

Autor: Kimberly A. Stigler, Arlene E. Kohn, Christopher J. McDougle, David J. Posey, Jonathan T. Diener, Craig A. Erickson, Lang Li

Publikováno v: Journal of Child and Adolescent Psychopharmacology. 19:265-274

The aim of this study was to determine the effectiveness and tolerability of aripiprazole for irritability in pervasive developmental disorder not otherwise specified (PDD-NOS) and Asperger's disorder.This is a 14-week, prospective, open-label invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b463568f187b6979b2b901ad64764d
https://doi.org/10.1089/cap.2008.093

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Akademický článek

Investigation of an outbreak of group A Streptococcus in a Regina retirement residence and personal care home, 2018.

Autor: A., Trecker M., C., Danielson, G., Koutsoulis, K., Lloyd, Tramer C., Benz, T., Diener, M., Hennink

Publikováno v: Canadian Journal of Infection Control / Revue Canadienne de Prévention des Infections; Winter2019, Vol. 34 Issue 4, p175-178, 4p

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Abstract B083: Population pharmacokinetics and pharmacodynamics for an oral Notch inhibitor, LY3039478, in patients with advanced cancer and healthy volunteers

Autor: Robert Bell, Jordi Rodon, J. T. Diener, Karim A. Benhadji, Claire Smith, Katharine Thorn, Demetrio Ortega, Eunice Yuen, Maria M. Posada, Jeffrey G. Suico, Christophe Massard

Publikováno v: Molecular Cancer Therapeutics. 17:B083-B083

Background: LY3039478 is an oral Notch inhibitor that prevents release of the Notch Intracellular Domain (NICD) by inhibiting proteolytic activity of the gamma (γ)-secretase complex. LY3039478 also inhibits production of plasma amyloid-beta (Aβ), w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af4d5a4419b8eb4c5a908f937b60675e
https://doi.org/10.1158/1535-7163.targ-17-b083

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SU-F-T-234: Quality Improvements in the Electronic Medical Record of Patients Treated with High Dose-Rate Brachytherapy

Autor: T Diener, D Wilkinson

Publikováno v: Medical Physics. 43:3516-3516

Purpose: To improve workflow efficiency and patient safety by assessing the quality control documentation for HDR brachytherapy within our Electronic Medical Record System (Mosaiq). Methods: A list of parameters based on NRC regulations, our quality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::997b344eadd5b67597b39d0b3061c00c
https://doi.org/10.1118/1.4956373

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SU-G-TeP2-07: Dosimetric Characterization of a New HDR Multi-Channel Esophageal Applicator for Brachytherapy

Autor: D Wilkinson, John F. Greskovich, A Zhao, T Diener, S Gao

Publikováno v: Medical Physics. 43:3664-3664

Purpose: To characterize the dose distribution of a new multi-channel esophageal applicator for brachytherapy HDR treatment, and particularly the effect of the presence of air or water in the applicator's expansion balloon. Methods: A new multi-chann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::232e9ee0d30bedc28ff866c85ab094c0
https://doi.org/10.1118/1.4957042

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