Zobrazeno 1 - 10
of 336
pro vyhledávání: '"T, Cresteil"'
Publikováno v:
British Journal of Clinical Pharmacology. 52:419-425
Aims Cisapride has been shown to cause QTc prolongation in neonates in the absence of any of the known risk factors ascribed to children or adults (excessive dosage, drug‐drug interactions). Our hypothesis was that the early neonatal liver may show
Autor:
T. Cresteil
Publikováno v:
Archives de Pédiatrie. 8:347-349
Autor:
T. Cresteil, D. Buisson, Isabelle Schmitz-Afonso, J Le Ven, David Touboul, Guy Lewin, B. Akagah, Pierre Champy
Publikováno v:
Toxicology Letters. 205:S50-S51
Autor:
T, Cresteil
Publikováno v:
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 8
Autor:
R N, Hines, Z, Luo, T, Cresteil, X, Ding, R A, Prough, J L, Fitzpatrick, S L, Ripp, K C, Falkner, N L, Ge, A, Levine, C J, Elferink
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
It is widely recognized that xenobiotic-metabolizing enzymes play a fundamental role in the basic processes of carcinogenesis and toxicity on one hand, and chemoprevention and drug efficacy on the other. Realization that different factors can profoun
Autor:
A, Santos, S, Zanetta, T, Cresteil, A, Deroussent, F, Pein, E, Raymond, L, Vernillet, M L, Risse, V, Boige, A, Gouyette, G, Vassal
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(5)
7-Ethyl-10[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin (CPT-11), a DNA topoisomerase I inhibitor, undergoes several metabolic pathways to generate conjugated and unconjugated derivatives that could be excreted from the body. The objective
Publikováno v:
Bulletin du cancer. 84(2)
The metabolism of paclitaxel and docetaxel by human liver microsomes was investigated in vitro. The main metabolite of paclitaxel formed in vitro was the 6 alpha-hydroxypaclitaxel: its formation largely exceeded the formation of other metabolites hyd
Publikováno v:
Cancer research. 56(1)
The metabolism of docetaxel by human liver microsomes was investigated in vitro and compared with that of paclitaxel. A main docetaxel metabolite was generated by human liver microsomes in the presence of NADPH: retention time in high pressure liquid
Publikováno v:
Cancer research. 54(2)
The biotransformation of taxol by human liver was investigated in vitro with microsomes isolated from adult and developing human tissues. In vitro, no metabolism was detected with kidney microsomes, whereas two metabolites were generated by liver mic
Autor:
Colin T. Dolphin, L.L. Poulsen, T. Kimura, J. Ozols, Elizabeth A. Shephard, Richard M. Philpot, A.E. Rettie, David E. Williams, D.M. Ziegler, Ronald N. Hines, E. Hodgson, M.P. Lawton, T. Cresteil, Ian Phillips, Adnan A. Elfarra, John R. Cashman
Publikováno v:
Archives of biochemistry and biophysics. 308(1)
A nomenclature based on comparisons of amino acid sequences is proposed for the members of the mammalian flavin-containing monooxygenase (FMO) gene family. This nomenclature is based on evidence of a single gene family composed of five genes. The per