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IL-25/IL-33–responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa

Autor: Lam, Emily P.S., Kariyawasam, Harsha H., Rana, Batika M.J., Durham, Stephen R., McKenzie, Andrew N.J., Powell, Nicholas, Orban, Nara, Lennartz-Walker, Melissa, Hopkins, Claire, Ying, Sun, Rimmer, Joanne, Lund, Valerie J., Cousins, David J., Till, Stephen J.

Publikováno v: Lam, E P S, Kariyawasam, H H, Rana, B M J, Durham, S R, McKenzie, A N J, Powell, N, Orban, N, Lennartz-Walker, M, Hopkins, C, Ying, S, Rimmer, J, Lund, V J, Cousins, D J & Till, S J 2016, ' IL-25/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa ', Journal of Allergy and Clinical Immunology, vol. 137, no. 5, pp. 1514-1524 . https://doi.org/10.1016/j.jaci.2015.10.019

BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSwNP) in Western countries is characterized by eosinophilia, IgE production, and TH2 cytokine expression. Type 2 innate lymphoid cells from polyps produce IL-5 and IL-13 in response to IL-25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7c3ab032d3429fb883a48761a9b4c98c

Antiapoptotic serine protease inhibitors contribute to survival of allergenic TH2 cells

Autor: Jeff N. Temblay, Fedina Olexandra, Wei Cheng, Mohamed H. Shamji, Philip G. Ashton-Rickardt, Stephen R. Durham, Susan M. Byrne, Ellen Macfarlane, Natalia do Couto Francisco, Fabian Jacubczik, Amy Switzer

Publikováno v: 581.e5

BACKGROUND: The mechanisms that regulate maintenance of persistent TH2 cells and potentiate allergic inflammation are not well understood. OBJECTIVE: The function of serine protease inhibitor 2A (Spi2A) was studied in mouse TH2 cells, and the serine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6404625aade266c8616945418a59ad
http://hdl.handle.net/10044/1/56312

Mucosal type 2 innate lymphoid cells are a key component of the allergic response to aeroallergen

Autor: Batika M. J. Rana, Aoife Cameron, David J. Cousins, Ajerico del Rosario, Trevor T. Hansel, David A. Jackson, Eteri Bakhsoliani, Jaideep Dhariwal, Michael R. Edwards, Malte Paulsen, Maria-Belen Trujillo-Torralbo, Ross P. Walton, Sebastian L. Johnston

RATIONALE: Newly characterised type 2 innate lymphoid cells display potent type 2 effector functionality, however their contribution to allergic airways inflammation and asthma is poorly understood. Mucosal biopsy used to characterise the airway muco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31804b0252d5a11b9591737029f26cb5
http://hdl.handle.net/10044/1/44042

Recent advances in the epigenetics and genomics of asthma

Autor: Martijn C. Nawijn, Gerard H. Koppelman

Publikováno v: Current Opinion in Allergy and Clinical Immunology; Vol 11

Purpose of review Epigenetics is the study of heritable changes in gene expression that occur without direct changes in the DNA sequence. Epigenetic mechanisms may explain important observations in asthma, such as the effect of the environment during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02668b611eb6ca047c39faa716cc92c6
https://doi.org/10.1097/aci.0b013e32834a9573