Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Szymon Pach"'
Autor:
Viviane Kremling, Bernhard Loll, Szymon Pach, Ismail Dahmani, Christoph Weise, Gerhard Wolber, Salvatore Chiantia, Markus C. Wahl, Nikolaus Osterrieder, Walid Azab
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Cell entry of most alphaherpesviruses is mediated by the binding of glycoprotein D (gD) to different cell surface receptors. Equine herpesvirus type 1 (EHV-1) and EHV-4 gDs interact with equine major histocompatibility complex I (MHC-I) to initiate e
Externí odkaz:
https://doaj.org/article/3f383c03112646479d3bee13a5b7a488
Autor:
Kristina Puls, Aina-Leonor Olivé-Marti, Szymon Pach, Birgit Pinter, Filippo Erli, Gerhard Wolber, Mariana Spetea
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 680 (2022)
Kappa-opioid receptor (KOR) antagonists are promising innovative therapeutics for the treatment of the central nervous system (CNS) disorders. The new scaffold opioid ligand, Compound A, was originally found as a mu-opioid receptor (MOR) antagonist b
Externí odkaz:
https://doaj.org/article/fd0890e09bed47b8a37fba0cfdcf4862
Autor:
Gerhard Wolber, Robert Schulz, Christoph Arkona, Umer Bin Abdul Aziz, Carolin Tauber, Szymon Pach, Jörg Rademann, Dirk Jochmans, Johan Neyts, Marisa Tügend, Rebekka Wamser
Publikováno v:
Angewandte Chemie. 133:13405-13413
Flaviviral infections are associated with an increased risk of neurological complications or hemorrhage. The flaviviral serine protease NS2B-NS3 is involved in the processing of a viral polyprotein into functional components of viral particles during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b5a571af0a2fc209d565658770a2cf
Autor:
Viviane Kremling, Bernhard Loll, Szymon Pach, Ismail Dahmani, Christoph Weise, Gerhard Wolber, Salvatore Chiantia, Markus C. Wahl, Nikolaus Osterrieder, Walid Azab
Cell entry of most alphaherpesviruses is mediated by the binding of glycoprotein D (gD) to different cell surface receptors. Equine herpesvirus type 1 (EHV-1) and EHV-4 gDs interact with equine major histocompatibility complex I (MHC-I) to initiate e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13028a3692731a41c33e6019cd79e3af
https://doi.org/10.1101/2022.06.10.495596
https://doi.org/10.1101/2022.06.10.495596
Autor:
Gerhard Wolber, Szymon Pach, Jörg Rademann, Carolin Tauber, Johan Neyts, Dirk Jochmans, Marisa Tügend, Robert Schulz, Christoph Arkona, Umer Bin Abdul Aziz, Rebekka Wamser
Publikováno v:
Angewandte Chemie (International Ed. in English)
The generation of bioactive molecules from inactive precursors is a crucial step in the chemical evolution of life, however, mechanistic insights into this aspect of abiogenesis are scarce. Here, we investigate the protein‐catalyzed formation of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efdcbabbb8a8dfdfc7b8dfd2ad33a44
https://lirias.kuleuven.be/handle/123456789/676358
https://lirias.kuleuven.be/handle/123456789/676358
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2266
Three-dimensional pharmacophore models have been proven extremely valuable in exploring novel chemical space through virtual screening. However, traditional pharmacophore-based approaches need ligand information and rely on static snapshots of highly
Publikováno v:
Drug discovery today. 26(10)
Human cytochrome P450 (CYP) enzymes are widely known for their pivotal role in the metabolism of drugs and other xenobiotics as well as of endogenous chemicals. In addition, CYPs are involved in numerous pathophysiological pathways and, hence, are th
Publikováno v:
Methods in Molecular Biology ISBN: 9781071612088
Three-dimensional pharmacophore models have been proven extremely valuable in exploring novel chemical space through virtual screening. However, traditional pharmacophore-based approaches need ligand information and rely on static snapshots of highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::440536e465103e20934d521ee9af3a5e
https://doi.org/10.1007/978-1-0716-1209-5_13
https://doi.org/10.1007/978-1-0716-1209-5_13
Publikováno v:
RSC Med Chem
Metabolic pathways mediated by human gut bacteria have emerged as potential therapeutic targets because of their association with the pathophysiology of various human diseases. The anaerobic transformation of choline into trimethylamine (TMA) by gut