Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Szymon Klossowski"'
Autor:
David S. Rogawski, Jing Deng, Hao Li, Hongzhi Miao, Dmitry Borkin, Trupta Purohit, Jiho Song, Jennifer Chase, Shuangjiang Li, Juliano Ndoj, Szymon Klossowski, EunGi Kim, Fengbiao Mao, Bo Zhou, James Ropa, Marta Z. Krotoska, Zhuang Jin, Patricia Ernst, Xiaomin Feng, Gang Huang, Kenichi Nishioka, Samantha Kelly, Miao He, Bo Wen, Duxin Sun, Andrew Muntean, Yali Dou, Ivan Maillard, Tomasz Cierpicki, Jolanta Grembecka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The histone methyltransferase ASH1L plays a role in various diseases, including cancer, and has been validated as a therapeutic target; however, no inhibitors of ASH1L have been reported. Here the authors present small molecule inhibitors of ASH1L an
Externí odkaz:
https://doaj.org/article/a51c519c90294569ac5da97219844f37
Autor:
Jolanta Grembecka, Tomasz Cierpicki, Jingya Wang, Hongzhi Miao, Shirish Shukla, Szymon Klossowski, Dmitry Borkin, Bhavna Malik, Katarzyna Kempinska
Supplementary Figure 1. Expression of menin, MLL1 and MLL2 in HCC cell lines; Supplementary Figure 2. MI-503 affects cell migration in HCC cell lines; Supplementary Figure 3. MI-503 does not induce toxicity in mice; Supplementary Table 1. Inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be63561bb0ef2b7f87c8ee30307ba90
https://doi.org/10.1158/1535-7163.22505353.v1
https://doi.org/10.1158/1535-7163.22505353.v1
Autor:
Jolanta Grembecka, Tomasz Cierpicki, Jingya Wang, Hongzhi Miao, Shirish Shukla, Szymon Klossowski, Dmitry Borkin, Bhavna Malik, Katarzyna Kempinska
RNA-seq data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50cf74a58c9cde940d8a65b1aa6476b7
https://doi.org/10.1158/1535-7163.22505350.v1
https://doi.org/10.1158/1535-7163.22505350.v1
Autor:
Jolanta Grembecka, Tomasz Cierpicki, Jingya Wang, Hongzhi Miao, Shirish Shukla, Szymon Klossowski, Dmitry Borkin, Bhavna Malik, Katarzyna Kempinska
Hepatocellular carcinoma (HCC) accounts for approximately 85% of malignant liver tumors and results in 600,000 deaths each year, emphasizing the need for new therapies. Upregulation of menin was reported in HCC patients and high levels of menin corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::379f98793388ac551f64a4cada70536c
https://doi.org/10.1158/1535-7163.c.6538030.v1
https://doi.org/10.1158/1535-7163.c.6538030.v1
Autor:
Szymon Klossowski, Hongzhi Miao, Katarzyna Kempinska, Tao Wu, Trupta Purohit, EunGi Kim, Brian M. Linhares, Dong Chen, Gloria Jih, Eric Perkey, Huang Huang, Miao He, Bo Wen, Yi Wang, Ke Yu, Stanley Chun-Wei Lee, Gwenn Danet-Desnoyers, Winifred Trotman, Malathi Kandarpa, Anitria Cotton, Omar Abdel-Wahab, Hongwei Lei, Yali Dou, Monica Guzman, Luke Peterson, Tanja Gruber, Sarah Choi, Duxin Sun, Pingda Ren, Lian-Sheng Li, Yi Liu, Francis Burrows, Ivan Maillard, Tomasz Cierpicki, Jolanta Grembecka
Publikováno v:
J Clin Invest
The protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays a critical role in acute leukemias with translocations of the MLL1 gene or with mutations in the nucleophosmin 1 (NPM1) gene. As a step toward clinical translatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29a63bac5d71d2f2ceab7e25e535675
https://europepmc.org/articles/PMC6994154/
https://europepmc.org/articles/PMC6994154/
Autor:
Christopher J. Halbrook, Li Zhang, Daniel M. Kremer, Elizabeth R. Lawlor, Ho-Joon Lee, Costas A. Lyssiotis, Sudha Sud, Armand Bankhead, Szymon Klossowski, Selina Shiqing K. Teh, Dafydd G. Thomas, Laurie K. Svoboda, Aaron Zebolsky, Sydney Treichel, Tomasz Cierpicki, Mats Ljungman, Brian Magnuson, Samuel A. Kerk, Jolanta Grembecka
Publikováno v:
The Journal of Pathology. 245:324-336
Developmental transcription programs are epigenetically regulated by multi-protein complexes, including the menin- and MLL-containing trithorax (TrxG) complexes, which promote gene transcription by depositing the H3K4me3 activating mark at target gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4111a13821d373f0cb151a66380bd2cc
https://doi.org/10.1002/path.5085
https://doi.org/10.1002/path.5085
Autor:
Shirish Shukla, Dmitry Borkin, Bhavna Malik, Tomasz Cierpicki, Jingya Wang, Katarzyna Kempińska, Szymon Klossowski, Jolanta Grembecka, Hongzhi Miao
Publikováno v:
Molecular Cancer Therapeutics. 17:26-38
Hepatocellular carcinoma (HCC) accounts for approximately 85% of malignant liver tumors and results in 600,000 deaths each year, emphasizing the need for new therapies. Upregulation of menin was reported in HCC patients and high levels of menin corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43c9c76289d9b4e147e89245635348f
https://doi.org/10.1158/1535-7163.mct-17-0580
https://doi.org/10.1158/1535-7163.mct-17-0580
Autor:
Trupta Purohit, Edyta Dyguda-Kazimierowicz, Tomasz Cierpicki, Wiktoria Jedwabny, Jolanta Grembecka, Szymon Klossowski
Publikováno v:
MedChemComm. 8:2216-2227
Development and binding affinity predictions of inhibitors targeting protein-protein interactions (PPI) still represent a major challenge in drug discovery efforts. This work reports application of a predictive non-empirical model of inhibitory activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdb3349913a84cc180bf9ca72dcb4e4c
https://doi.org/10.1039/c7md00170c
https://doi.org/10.1039/c7md00170c
Autor:
Szymon Klossowski, H. D. Hollis Showalter, Tomasz Cierpicki, Roderick Joseph Sorenson, Margaret E. Gnegy, Yafei Jin, Colleen Carpenter
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:5495-5504
The clinical selective estrogen receptor modulator tamoxifen is also a modest inhibitor of protein kinase C, a target implicated in several untreatable brain diseases such as amphetamine abuse. This inhibition and tamoxifen’s ability to cross the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1313aca2d8f7627f43562e5e79fedc1b
https://doi.org/10.1016/j.bmc.2016.09.002
https://doi.org/10.1016/j.bmc.2016.09.002
Autor:
Anna Żądło-Dobrowolska, Szymon Klossowski, Ryszard Ostaszewski, Daniel Paprocki, Dominik Koszelewski
Publikováno v:
Chemistry - A European Journal. 22:16684-16689
The application of the Ugi reaction to the construction of new peptide scaffolds is an important goal of organic chemistry. To date, there are no examples of the Ugi reaction being performed with a cyclic imine and amine simultaneously. The applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b08f5c3ede24ce463aab3c6cfdf8e83
https://doi.org/10.1002/chem.201603412
https://doi.org/10.1002/chem.201603412