Coupled MD simulations and NMR reveal that the intrinsically disordered domain of the breast-cancer susceptibility 1 protein (BRCA1) binds head-on to DNA double-strand ends

Autor: Kateryna Che, Thomas Kress, Michał Górka, Szymon Żerko, Wiktor Kozminski, Dennis Kurzbach

Publikováno v: Journal of Magnetic Resonance Open, Vol 12, Iss , Pp 100069- (2022)

Mutations of the breast cancer susceptibility 1 (BRCA1) gene are associated with high risks of breast and ovarian cancer, not least due to the vital role of the BRCA1 gene product in DNA double-strand repair. Strikingly, little is known about the str

Externí odkaz: https://doaj.org/article/f1ed9457ba5741b1aa6d8a99d82757e1

Hyperphosphorylation of Human Osteopontin and Its Impact on Structural Dynamics and Molecular Recognition

Autor: Szymon Żerko, Clara Conrad-Billroth, Wiktor Koźmiński, Borja Mateos, Robert Konrat, Gerald Platzer, Dorothea Anrather, Julian Holzinger, Marco Sealey-Cardona

Publikováno v: Biochemistry

Protein phosphorylation is an abundant post-translational modification (PTM) and an essential modulator of protein functionality in living cells. Intrinsically disordered proteins (IDPs) are particular targets of PTM protein kinases due to their invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514a828eb6c12827b4119a3658723ee7
http://europepmc.org/articles/PMC8154273

Structure, dynamics, and function of SrnR, a transcription factor for nickel-dependent gene expression

Autor: Wiktor Koźmiński, Stefano Ciurli, Michele Cianci, Luca Mazzei, Szymon Żerko, Barbara Zambelli, Ylenia Beniamino, Francesco Musiani

Publikováno v: Metallomics 13(12), mfab069 (2021). doi:10.1093/mtomcs/mfab069

Streptomyces griseus, a bacterium producing antibacterial drugs and featuring possible application in phytoremediation, expresses two metal-dependent superoxide dismutase (SOD) enzymes, containing either Fe(II) or Ni(II) in their active site. In part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de38229d7bab27c486355d7aed4c127
https://doi.org/10.1093/mtomcs/mfab069

Reconstruction of non-uniformly sampled five-dimensional NMR spectra by signal separation algorithm

Autor: Krzysztof Kosiński, Wiktor Koźmiński, Szymon Żerko, Jan Stanek, Michał Górka

Publikováno v: Journal of Biomolecular Nmr

A method for five-dimensional spectral reconstruction of non-uniformly sampled NMR data sets is proposed. It is derived from the previously published signal separation algorithm, with major alterations to avoid unfeasible processing of an entire five

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75a4cc12110839a0b0ec2d6a181962f
http://europepmc.org/articles/PMC5504137

Structure and dynamics of Helicobacter pylori nickel-chaperone HypA: an integrated approach using NMR spectroscopy, functional assays and computational tools

Autor: Wiktor Koźmiński, Benjamin Bardiaux, Barbara Zambelli, Ryan C. Johnson, Chris A. E. M. Spronk, Priyanka Basak, D. Scott Merrell, Francesco Musiani, Mario Piccioli, Michael J. Maroney, Stefano Ciurli, Michał Górka, Faith C. Blum, Szymon Żerko, Heidi Hu

Publikováno v: Journal of Biological Inorganic Chemistry
Journal of Biological Inorganic Chemistry, 2018, 23 (8), pp.1309-1330. ⟨10.1007/s00775-018-1616-y⟩
Journal of Biological Inorganic Chemistry, Springer Verlag, 2018, 23 (8), pp.1309-1330. ⟨10.1007/s00775-018-1616-y⟩

International audience; Helicobacter pylori HypA (HpHypA) is a metallochaperone necessary for maturation of [Ni,Fe]-hydrogenase and urease, the enzymes required for colonization and survival of H. pylori in the gastric mucosa. HpHypA contains a struc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf4128788c96d506cc2d51133bbe116
https://hal-pasteur.archives-ouvertes.fr/pasteur-02329962