Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Szuna, A."'
Autor:
Roger W. Blain, Alice J. Szuna
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 620:211-216
Analysis of a new antibacterial agent, Ro 23-9424 (I), in plasma has been complicated by the fact that its metabolite, fleroxacin (II), is formed not only in vivo, but also nonenzymatically by the hydrolysis of the ester bond of I. In order to minimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9795ad5537c6a531505994c4764fc56a
https://doi.org/10.1016/0378-4347(93)80006-p
https://doi.org/10.1016/0378-4347(93)80006-p
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 616:297-303
Ro 23-7637 (I) is a new drug under development for the treatment of metabolic diseases. A high-performance liquid chromatographic-ultraviolet detection (HPLC-UV) analytical procedure for its analysis in dog plasma was developed and is reported here.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e3a05dd123804ec7b77153fdb26b53
https://doi.org/10.1016/0378-4347(93)80398-n
https://doi.org/10.1016/0378-4347(93)80398-n
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(2)
The disposition of the antipsoriatic agent, acitretin, was investigated in six healthy human volunteers who each received a single, oral 50 mg dose of [14C]acitretin (50 microCi). plasma, urine, and feces were collected for 240 hr after administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a957fd6d4a671d0ecdfd52f1620092dc
https://pubmed.ncbi.nlm.nih.gov/8013276
https://pubmed.ncbi.nlm.nih.gov/8013276
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 12(1)
A highly sensitive LC method has been developed and validated for quantitation of Ro 24-0238 in human plasma using Ro 24-2446 as an internal standard. With 1 ml of plasma, the limit of quantitation of the method was 50 pg ml−1 of Ro 24-0238. After
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1684ffd23c4f53bf27221f8023cfc8
https://pubmed.ncbi.nlm.nih.gov/8161596
https://pubmed.ncbi.nlm.nih.gov/8161596
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(2)
Metabolism and route of excretion of [14C]rimantadine hydrochloride was studied in male rats after single po (60 mg/kg) and iv doses (15 mg/kg) and in male dogs (5 or 10 mg/kg po and 5 mg/kg iv). Total 14C excretion in urine (po and iv) in both speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f377d5c5e0709c479d93e548a5fb531
https://pubmed.ncbi.nlm.nih.gov/1676641
https://pubmed.ncbi.nlm.nih.gov/1676641
Autor:
Massarella, Joseph W., Khoo, Ko-Chin, Szuna, Alice J., Sandor, Deborah A., Morganroth, Joel, Aogaichi, Keiko
Publikováno v:
Journal of Clinical Pharmacology; Feb1986, Vol. 26 Issue 2, p125-130, 6p
Autor:
Brazzell, Romulus K., Khoo, Ko-Chin, Szuna, Alice J., Sandor, Deborah, Aogaichi, Keiko, Wills, Robert J.
Publikováno v:
Journal of Clinical Pharmacology; Sep1985, Vol. 25 Issue 6, p418-423, 6p
Publikováno v:
Journal of Clinical Pharmacology; Jul1984, Vol. 24 Issue 7, p283-288, 6p
Publikováno v:
Clinical Pharmacology & Therapeutics; Nov1984, Vol. 36 Issue 5, p613-619, 7p
Autor:
A Szuna, J. F. Blount, M Petrin, Jerome J. Kamm, D H Ellis, Erno Mohacsi, J Rao, Floie M. Vane
Publikováno v:
Biological Mass Spectrometry. 5:498-507
The major metabolic pathway of the (-) enantiomer and the (+) enantiomer of 2-hydroxy-N-cyclopropylmethylmorphinan in dogs was shown to be conjugation with glucuronic acid and/or sulfate. Gas chromatography mass spectrometry, nuclear magnetic resonan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2644db040a3ab64bede5a8d03978c4d
https://doi.org/10.1002/bms.1200050808
https://doi.org/10.1002/bms.1200050808