Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Szu-Yuan Pu"'
Publikováno v:
eLife, Vol 7 (2018)
Dengue and Zika viral infections affect millions of people annually and can be complicated by hemorrhage and shock or neurological manifestations, respectively. However, a thorough understanding of the host response to these viruses is lacking, partl
Externí odkaz:
https://doaj.org/article/7ecd020c69f04a72a1f3578b32b0f33e
Autor:
Szu-Yuan Pu, 蒲思源
102
Despite tremendous efforts to improve the methodology for constructing flavivirus infectious cDNAs, the manipulation of flavivirus cDNAs remains a difficult task in bacteria. Here, we have identified the cryptic E. coli promoter (ECP) activi
Despite tremendous efforts to improve the methodology for constructing flavivirus infectious cDNAs, the manipulation of flavivirus cDNAs remains a difficult task in bacteria. Here, we have identified the cryptic E. coli promoter (ECP) activi
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/16445653588121221792
Autor:
Szu-Yuan Pu, 蒲思源
92
Cyclin dependent kinase is defined as its activation requires the binding of cyclin partner. In animal, 9 groups of CDK have been identified and named CDK1-CDK9. The CDK7, CDK8, and CDK9 have been known to be able to phosphorylate the C-termi
Cyclin dependent kinase is defined as its activation requires the binding of cyclin partner. In animal, 9 groups of CDK have been identified and named CDK1-CDK9. The CDK7, CDK8, and CDK9 have been known to be able to phosphorylate the C-termi
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/41011986721070467548
Autor:
Rina Barouch-Bentov, Ling-Jie Gao, Piet Herdewijn, J.M. Elkins, Fiona J. Sorrell, Shirit Einav, Laura I. Prugar, Stefan Knapp, Steven De Jonghe, Jennifer M. Brannan, Danielle Dorosky, Mathy Froeyen, Sven Verdonck, John M. Dye, Szu-Yuan Pu
Publikováno v:
J Med Chem
There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine-threonine protein kinase that functions as a key regulator of the clathrin-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7c0b65a98e24d3c2bd307d580b61d5
https://doi.org/10.1021/acs.jmedchem.9b00136
https://doi.org/10.1021/acs.jmedchem.9b00136
Autor:
Laura I. Prugar, Szu-Yuan Pu, Sirle Saul, Jennifer M. Brannan, Marwah Karim, Stanford Schor, Makeda Robinson, Shirit Einav, Sathish Kumar, Danielle Dorosky, John M. Dye
Publikováno v:
Antiviral Res
Global health is threatened by emerging viruses, many of which lack approved therapies and effective vaccines, including dengue, Ebola, and Venezuelan equine encephalitis. We previously reported that AAK1 and GAK, two of the four members of the under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff53a1c1ed79f024dd043e3ea01afbd4
https://pubmed.ncbi.nlm.nih.gov/33137362
https://pubmed.ncbi.nlm.nih.gov/33137362
Autor:
Fabio Zanini, Stanford Schor, Rina Barouch-Bentov, Claude M. Nagamine, Shirit Einav, Szu-Yuan Pu, Elena Bekerman, Fei Xiao
Publikováno v:
Antiviral Research. 155:67-75
There is an urgent need for strategies to combat dengue virus (DENV) infection; a major global threat. We reported that the cellular kinases AAK1 and GAK regulate intracellular trafficking of multiple viruses and that sunitinib and erlotinib, approve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02786920625041731a41217c095cec5
https://doi.org/10.1016/j.antiviral.2018.05.001
https://doi.org/10.1016/j.antiviral.2018.05.001
Autor:
Laura I. Prugar, Stanford Schor, Shirit Einav, Steven De Jonghe, Jef Rozenski, Cecilia M. O’Brien, Randy Wouters, Jennifer M. Brannan, Rina Barouch-Bentov, Piet Herdewijn, John M. Dye, Szu-Yuan Pu
Publikováno v:
Journal of Medicinal Chemistry. 61:6178-6192
There is an urgent need for strategies to combat dengue and other emerging viral infections. We reported that cyclin G-associated kinase (GAK), a cellular regulator of the clathrin-associated host adaptor proteins AP-1 and AP-2, regulates intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aeadce3e83c0bd8e0cc0bb4d3dbe2d9
https://doi.org/10.1021/acs.jmedchem.8b00613
https://doi.org/10.1021/acs.jmedchem.8b00613
Autor:
Roberto Mateo, Steven De Jonghe, Fei Xiao, Claude M. Nagamine, Russell R. Bakken, Ana Shulla, Michael S. Diamond, Gregory Neveu, Piet Herdewijn, Rina Barouch-Bentov, Jennifer M. Brannan, Jennifer Govero, Szu-Yuan Pu, Elena Bekerman, John M. Dye, Glenn Randall, Shirit Einav, Stanley Wang
Publikováno v:
Journal of Clinical Investigation. 127:1338-1352
Global health is threatened by emerging viral infections, which largely lack effective vaccines or therapies. Targeting host pathways that are exploited by multiple viruses could offer broad-spectrum solutions. We previously reported that AAK1 and GA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d60dd6e0a9b7846c64764ea6c62fcf
https://doi.org/10.1172/jci89857
https://doi.org/10.1172/jci89857
Autor:
Szu-Yuan Pu, Steven De Jonghe, Piet Herdewijn, Mathy Froeyen, Belén Martínez-Gualda, Shirit Einav
Publikováno v:
Bioorganicmedicinal chemistry. 28(1)
Previously, we reported the discovery of 3,6-disubstituted isothiazolo[4,3-b]pyridines as potent and selective cyclin G-associated kinase (GAK) inhibitors with promising antiviral activity. In this manuscript, the structure-activity relationship stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08ff6d79213768c576cca121b0feaf2
https://pubmed.ncbi.nlm.nih.gov/31757682
https://pubmed.ncbi.nlm.nih.gov/31757682
Autor:
Yves Jacob, Sathish Kumar, Fei Xiao, Albert Lu, Rina Barouch-Bentov, Szu-Yuan Pu, Caroline Demeret, Elise Biquand, Stanford Schor, Shirit Einav, Brett D. Lindenbach
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2019, 26 (7), pp.1800-1814.e5. ⟨10.1016/j.celrep.2019.01.075⟩
Cell Reports, Vol 26, Iss 7, Pp 1800-1814.e5 (2019)
Cell Reports, 2019, 26 (7), pp.1800-1814.e5. ⟨10.1016/j.celrep.2019.01.075⟩
Cell reports
Cell Reports, Elsevier Inc, 2019, 26 (7), pp.1800-1814.e5. ⟨10.1016/j.celrep.2019.01.075⟩
Cell Reports, Vol 26, Iss 7, Pp 1800-1814.e5 (2019)
Cell Reports, 2019, 26 (7), pp.1800-1814.e5. ⟨10.1016/j.celrep.2019.01.075⟩
Cell reports
SUMMARY The mechanisms that regulate envelopment of HCV and other viruses that bud intracellularly and/or lack late-domain motifs are largely unknown. We reported that K63 polyubiquitination of the HCV nonstructural (NS) 2 protein mediates HRS (ESCRT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf1ba02e20be3766101f24450773389
https://hal-pasteur.archives-ouvertes.fr/pasteur-02077482/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-02077482/document