Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Szu-Chin Fu"'
Publikováno v:
eLife, Vol 6 (2017)
Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015). Here, we show crystal structures of
Externí odkaz:
https://doaj.org/article/efb896d9a336473ebac1e4763f220ba6
Publikováno v:
eLife, Vol 4 (2015)
The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure. The plasticity of the CRM1-NES inte
Externí odkaz:
https://doaj.org/article/50e3f5cb3a1f4f2187bd39729518a95e
Autor:
Szu-Chin Fu, 傅思縉
92
In this thesis, an approach to predictβ-strand pairing and pairing orientation is proposed. Support Vector Machines (SVM) is used with a representative subset of Protein Data Bank (PDB) to make a 3-state prediction and achieves an overall pr
In this thesis, an approach to predictβ-strand pairing and pairing orientation is proposed. Support Vector Machines (SVM) is used with a representative subset of Protein Data Bank (PDB) to make a 3-state prediction and achieves an overall pr
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/37580858268478813465
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
Supplementary Data, Table S1, S3, S6, S8, S10-S13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b265e4961eac4720f5366a19b7c1c2
https://doi.org/10.1158/2159-8290.22535216
https://doi.org/10.1158/2159-8290.22535216
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
KRAS is the most frequently mutated driver of pancreatic, colorectal, and non–small cell lung cancers. Direct KRAS blockade has proved challenging, and inhibition of a key downstream effector pathway, the RAF–MEK–ERK cascade, has shown limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4207250379f0cc7e1fcd4e873b0d65cb
https://doi.org/10.1158/2159-8290.c.6547790.v1
https://doi.org/10.1158/2159-8290.c.6547790.v1
Autor:
Daniel M. Halperin, Gauri R. Varadhachary, James C. Yao, Scott E. Woodman, Keith F. Fournier, Scott Kopetz, Ajaykumar C. Morani, Walter C. Darbonne, Katja Schulze, Shannon Dervin, Cindy Yun, Edward McKenna, Patricia Cortazar, Patrick Hwu, Armeen Mahvash, Anuj Verma, Pamela Villalobos, Honglei Chen, Edwin R. Parra Cuentas, Luisa M. Solis Soto, Dipen M. Maru, Andrew P. Futreal, Ignacio I. Wistuba, Paul F. Mansfield, Christopher P. Scally, Richard E. Royal, Seema Prasad, Anais Malpica, Szu-Chin Fu, Mark Knafl, Anneleis F. Willett, Michael J. Overman, Suyu Liu, Kanwal Raghav
Malignant peritoneal mesothelioma (MPeM) is a rare but aggressive malignancy with limited treatment options. VEGF inhibition enhances efficacy of immune-checkpoint inhibitors by reworking the immunosuppressive tumor milieu. Efficacy and safety of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810c1697e03dca3033be01a2d214aa5c
https://doi.org/10.1158/2159-8290.c.6549433.v1
https://doi.org/10.1158/2159-8290.c.6549433.v1
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
Supplementary Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d96dfb43e0dbbd26e81b12152a9d88c
https://doi.org/10.1158/2159-8290.22535234
https://doi.org/10.1158/2159-8290.22535234
Autor:
Daniel M. Halperin, Suyu Liu, Arvind Dasari, David Fogelman, Priya Bhosale, Armeen Mahvash, Jeannelyn S. Estrella, Laura Rubin, Ajaykumar C. Morani, Mark Knafl, Tim A. Overeem, Szu-Chin Fu, Luisa M. Solis, Edwin Parra Cuentas, Anuj Verma, Hong-Lei Chen, Swati Gite, Priya Subashchandrabose, Shannon Dervin, Katja Schulze, Walter C. Darbonne, Cindy Yun, Ignacio I. Wistuba, P. Andrew Futreal, Scott E. Woodman, James C. Yao
Publikováno v:
JAMA Oncol
IMPORTANCE: Therapies for patients with advanced well-differentiated neuroendocrine tumors (NETs) have expanded but remain inadequate, with patients dying of disease despite recent advances in NET therapy. While patients with other cancers have seen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dddac8d2ce3b68691ad8b930d043467
https://europepmc.org/articles/PMC8990358/
https://europepmc.org/articles/PMC8990358/
Autor:
Szu-Chin Fu, Norbert Kraut, Rachel L Mendes, Marco H. Hofmann, Michael Gmachl, Peter Ettmayer, Katharina Schipany, Juergen Ramharter, Joseph R. Marszalek, Michael P. Sanderson, Tobias Wunberg, Fabio Savarese, Mark Petronczki, Timothy P. Heffernan, Thomas Gerstberger, Jark Böttcher, Mark Pearson, Dana-Adriana Botesteanu, Daniel Gerlach, Dirk Kessler, Franziska Schachinger, Klaus Rumpel, Jessica Teh, Jonathan O’Connell, Christiane Kofink, Heribert Arnhof, Simone Lieb, Jürgen Moll, Christopher P. Vellano, Nikolai Pototschnig, Andreas Zoephel, Darryl B. McConnell, Francesca Trapani
Publikováno v:
Cancer discovery. 11(1)
KRAS is the most frequently mutated driver of pancreatic, colorectal, and non–small cell lung cancers. Direct KRAS blockade has proved challenging, and inhibition of a key downstream effector pathway, the RAF–MEK–ERK cascade, has shown limited
Publikováno v:
Molecular Biology of the Cell
CRM1 (Exportin1/XPO1) exports hundreds of broadly functioning protein cargoes out of the cell nucleus by binding to their classical nuclear export signals (NESs). The 8- to 15-amino-acid-long NESs contain four to five hydrophobic residues and are hig