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Clinical and virological responses to a broad-spectrum human monoclonal antibody in an influenza virus challenge study.

Autor: Sloan SE; Visterra, Inc., Waltham, MA, 02451, USA., Szretter KJ; Takeda Pharmaceuticals International, Inc., Cambridge, Massachusetts 02139, USA., Sundaresh B; Boston College, Chestnut Hill, MA, USA., Narayan KM; Visterra, Inc., Waltham, MA, 02451, USA., Smith PF; Certara, Parsippany, NJ, 07054, USA., Skurnik D; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Institut Necker-Enfants Malades, INSERM U1151, CNRS UMR, 8253, Paris, France; Université Paris Descartes, Paris, France; Service de Microbiologie, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France., Bedard S; Clin Ops Solutions, Medford, MA, USA., Trevejo JM; SmartPharm Therapeutics, Inc., Cambridge, MA, USA., Oldach D; Visterra, Inc., Waltham, MA, 02451, USA., Shriver Z; Visterra, Inc., Waltham, MA, 02451, USA. Electronic address: zshriver@visterrainc.com.

Publikováno v: Antiviral research [Antiviral Res] 2020 Dec; Vol. 184, pp. 104763. Date of Electronic Publication: 2020 Mar 07.

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

Autor: Wang F; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Alain T; Children's Hospital of Eastern Ontario Research Institute and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8L1, Canada., Szretter KJ; Department of Medicine, Molecular Microbiology, Pathology & Immunology, Washington, University School of Medicine, St Louis, MO 63110, United States of America., Stephenson K; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Pol JG; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Atherton MJ; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Hoang HD; Children's Hospital of Eastern Ontario Research Institute and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8L1, Canada., Fonseca BD; Children's Hospital of Eastern Ontario Research Institute and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8L1, Canada., Zakaria C; Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada., Chen L; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Rangwala Z; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Hesch A; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Chan ESY; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Tuinman C; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Suthar MS; Department of Pediatrics, Emory Vaccine Center, Emory University, Atlanta, GA 30329, United States of America., Jiang Z; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, United States of America., Ashkar AA; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Thomas G; Department of of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati Medical School, Cincinnati, 45267-0508 OH, United States of America.; Laboratory of Metabolism and Cancer, Catalan Institute of Oncology, ICO, Bellvitge Biomedical Research Institute, IDIBELL, 08908 Barcelona, Spain.; Departament Ciències Fisiològiques II, Facultat de Medicina, Universitat de Barcelona, 08908, Barcelona, Spain., Kozma SC; Department of of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati Medical School, Cincinnati, 45267-0508 OH, United States of America.; Laboratory of Metabolism and Cancer, Catalan Institute of Oncology, ICO, Bellvitge Biomedical Research Institute, IDIBELL, 08908 Barcelona, Spain., Gale M Jr; Department of Immunology, University of Washington School of Medicine, Seattle, Washington, WA98195, United States of America., Fitzgerald KA; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, United States of America., Diamond MS; Department of Medicine, Molecular Microbiology, Pathology & Immunology, Washington, University School of Medicine, St Louis, MO 63110, United States of America., Mossman K; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Sonenberg N; Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada., Wan Y; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Lichty BD; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.

Publikováno v: Nature immunology [Nat Immunol] 2016 May; Vol. 17 (5), pp. 514-522. Date of Electronic Publication: 2016 Apr 04.

Safety and Upper Respiratory Pharmacokinetics of the Hemagglutinin Stalk-Binding Antibody VIS410 Support Treatment and Prophylaxis Based on Population Modeling of Seasonal Influenza A Outbreaks.

Autor: Wollacott AM; Visterra Inc., One Kendall Square, Cambridge, MA 02139, USA., Boni MF; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Szretter KJ; Visterra Inc., One Kendall Square, Cambridge, MA 02139, USA., Sloan SE; Visterra Inc., One Kendall Square, Cambridge, MA 02139, USA., Yousofshahi M; Visterra Inc., One Kendall Square, Cambridge, MA 02139, USA., Viswanathan K; Visterra Inc., One Kendall Square, Cambridge, MA 02139, USA., Bedard S; Visterra Inc., One Kendall Square, Cambridge, MA 02139, USA., Hay CA; Visterra Inc., One Kendall Square, Cambridge, MA 02139, USA., Smith PF; d3 Medicine LLC, Parsippany, NJ, USA., Shriver Z; Visterra Inc., One Kendall Square, Cambridge, MA 02139, USA., Trevejo JM; Visterra Inc., One Kendall Square, Cambridge, MA 02139, USA.

Publikováno v: EBioMedicine [EBioMedicine] 2016 Feb 26; Vol. 5, pp. 147-55. Date of Electronic Publication: 2016 Feb 26 (Print Publication: 2016).

A broadly neutralizing human monoclonal antibody is effective against H7N9.

Autor: Tharakaraman K; Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;, Subramanian V; Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;, Viswanathan K; Visterra, Inc., Cambridge, MA 02139;, Sloan S; Visterra, Inc., Cambridge, MA 02139;, Yen HL; School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region of China, Pokfulam, Hong Kong;, Barnard DL; Institute of Antiviral Research, Utah State University, Logan, UT 84322., Leung YH; School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region of China, Pokfulam, Hong Kong;, Szretter KJ; Visterra, Inc., Cambridge, MA 02139;, Koch TJ; Visterra, Inc., Cambridge, MA 02139;, Delaney JC; Visterra, Inc., Cambridge, MA 02139;, Babcock GJ; Visterra, Inc., Cambridge, MA 02139;, Wogan GN; Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; wogan@mit.edu rams@mit.edu zshriver@visterrainc.com., Sasisekharan R; Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; wogan@mit.edu rams@mit.edu zshriver@visterrainc.com., Shriver Z; Visterra, Inc., Cambridge, MA 02139; wogan@mit.edu rams@mit.edu zshriver@visterrainc.com.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Sep 01; Vol. 112 (35), pp. 10890-5. Date of Electronic Publication: 2015 Aug 17.