A novel transposable element-mediated mechanism causes antiviral resistance in Drosophila through truncating the Veneno protein

Autor: Brosh, Osama, Fabian, Daniel K, Cogni, Rodrigo, Tolosana, Ignacio, Day, Jonathan P, Olivieri, Francesca, Merckx, Manon, Akilli, Nazli, Szkuta, Piotr, Jiggins, Francis M

Hosts are continually selected to evolve new defenses against an ever-changing array of pathogens. To understand this process, we examined the genetic basis of resistance to the Drosophila A virus in Drosophila melanogaster. In a natural population,

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https://www.repository.cam.ac.uk/handle/1810/337566

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A novel transposable element-mediated mechanism causes antiviral resistance in Drosophila through truncating the Veneno protein.

Autor: Brosh O; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom., Fabian DK; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom., Cogni R; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom.; Department of Ecology, University of São Paulo, 05508-220 São Paulo, Brazil., Tolosana I; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom., Day JP; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom., Olivieri F; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom., Merckx M; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom., Akilli N; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom., Szkuta P; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom., Jiggins FM; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jul 19; Vol. 119 (29), pp. e2122026119. Date of Electronic Publication: 2022 Jul 11.