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Bioengineering of human thyrotropin superactive analogs by site-directed "lysine-scanning" mutagenesis. Cooperative effects between peripheral loops.

Autor: Leitolf, H, Tong, K P, Grossmann, M, Weintraub, B D, Szkudlinski, M W

Publikováno v: Journal of Biological Chemistry; September 2000, Vol. 275 Issue: 35 p27457-65, 9p

Substitution of the seat-belt region of the thyroid-stimulating hormone (TSH) beta-subunit with the corresponding regions of choriogonadotropin or follitropin confers luteotropic but not follitropic activity to chimeric TSH.

Autor: Grossmann, M, Szkudlinski, M W, Wong, R, Dias, J A, Ji, T H, Weintraub, B D

Publikováno v: Journal of Biological Chemistry; June 1997, Vol. 272 Issue: 24 p15532-40, 9p

Subunit-specific functions of N-linked oligosaccharides in human thyrotropin: role of terminal residues of alpha- and beta-subunit oligosaccharides in metabolic clearance and bioactivity.

Autor: Szkudlinski, M W, Thotakura, N R, Weintraub, B D

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; September 1995, Vol. 92 Issue: 20 p9062-9066, 5p

Human thyroid-stimulating hormone: structure-function analysis.

Autor: Szkudlinski MW; Laboratory of Molecular Endocrinology, Department of Medicine, University of Maryland School of Medicine and the Institute of Human Virology, Medical Biotechnology Center, 725 West Lombard Street, Baltimore, Maryland 21201-1009, USA. szkudlin@umbi.umd.edu, Grossmann M, Leitolf H, Weintraub BD

Publikováno v: Methods (San Diego, Calif.) [Methods] 2000 May; Vol. 21 (1), pp. 67-81.