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Akademický článek

A Novel Dual-Function Nitric Oxide Donor Therapy for Preeclampsia—A Proof-of-Principle Study in a Murine Model

Autor: Diana Pintye, Réka E. Sziva, Lauren A. Biwer, Esilida Sula Karreci, Sonako Jacas, Maxim Mastyugin, Marianna Török, Brett C. Young, Prakash Jagtap, Garry J. Southan, Iris Z. Jaffe, Zsuzsanna K. Zsengellér

Publikováno v: Antioxidants, Vol 12, Iss 12, p 2036 (2023)

Background: Preeclampsia (PE) is a hypertensive disorder of pregnancy that is associated with substantial morbidity and mortality for the mother and fetus. Reduced nitric oxide bioavailability and oxidative stress contribute to the maternal and fetal

Externí odkaz: https://doaj.org/article/f21fa703289f4b9398e62a8ef00663d3

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Akademický článek

A Novel Dual-Function Redox Modulator Relieves Oxidative Stress and Anti-Angiogenic Response in Placental Villus Explant Exposed to Hypoxia—Relevance for Preeclampsia Therapy

Autor: Diana Pintye, Réka E. Sziva, Maxim Mastyugin, Brett C. Young, Sonako Jacas, Marianna Török, Saira Salahuddin, Prakash Jagtap, Garry J. Southan, Zsuzsanna K. Zsengellér

Publikováno v: Biology, Vol 12, Iss 9, p 1229 (2023)

Background: Preeclampsia (PE) is a severe, life-threatening complication during pregnancy (~5–7%), and no causative treatment is available. Early aberrant spiral artery remodeling is associated with placental stress and the release of oxygen radica

Externí odkaz: https://doaj.org/article/6d4aee7da3784754b6504db4a144336f

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Akademický článek

Nitroxide—HMP—Protects Human Trophoblast HTR-8/SVneo Cells from H2O2-Induced Oxidative Stress by Reducing the HIF1A Signaling Pathway

Autor: Diana Pintye, Réka Eszter Sziva, Maxim Mastyugin, Marianna Török, Sonako Jacas, Agnes Lo, Saira Salahuddin, Zsuzsanna K. Zsengellér

Publikováno v: Antioxidants, Vol 12, Iss 8, p 1578 (2023)

Preeclampsia (PE) is a pregnancy-specific syndrome affecting 5–7% of patients. There is no effective treatment available. Early abnormal placental development is associated with oxidative stress (OS) and a release of reactive oxygen species (ROS) i

Externí odkaz: https://doaj.org/article/303949927fb940268b508d7af93108bd

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Akademický článek

Network analysis of the left anterior descending coronary arteries in swim-trained rats by an in situ video microscopic technique

Autor: Marianna Török, Petra Merkely, Anna Monori-Kiss, Eszter Mária Horváth, Réka Eszter Sziva, Borbála Péterffy, Attila Jósvai, Alex Ali Sayour, Attila Oláh, Tamás Radovits, Béla Merkely, Nándor Ács, György László Nádasy, Szabolcs Várbíró

Publikováno v: Biology of Sex Differences, Vol 12, Iss 1, Pp 1-17 (2021)

Abstract Background We aimed to identify sex differences in the network properties and to recognize the geometric alteration effects of long-term swim training in a rat model of exercise-induced left ventricular (LV) hypertrophy. Methods Thirty-eight

Externí odkaz: https://doaj.org/article/c0126df8e2644f869048cc2d0f41b370

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Akademický článek

Vitamin D Deficiency Reduces Vascular Reactivity of Coronary Arterioles in Male Rats

Autor: Zoltán Fontányi, Réka Eszter Sziva, Éva Pál, Leila Hadjadj, Anna Monori-Kiss, Eszter Mária Horváth, Rita Benkő, Attila Magyar, Andrea Heinzlmann, Zoltán Benyó, György L. Nádasy, Gabriella Masszi, Szabolcs Várbíró

Publikováno v: Current Issues in Molecular Biology, Vol 43, Iss 1, Pp 79-92 (2021)

Background: Vitamin D deficiency (VDD) may be considered an independent cardiovascular (CV) risk factor, and it is well known that CV risk is higher in males. Our goal was to investigate the pharmacological reactivity and receptor expression of intra

Externí odkaz: https://doaj.org/article/706ff9744b544c058f0e01b346ad4538

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