IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Autor: Margolskee, Alison, Darwich, Adam S., Pepin, Xavier, Aarons, Leon, Galetin, Aleksandra, Rostami-Hodjegan, Amin, Carlert, Sara, Hammarberg, Maria, Hilgendorf, Constanze, Johansson, Pernilla, Karlsson, Eva, Murphy, Dónal, Tannergren, Christer, Thörn, Helena, Yasin, Mohammed, Mazuir, Florent, Nicolas, Olivier, Ramusovic, Sergej, Xu, Christine, Pathak, Shriram M., Korjamo, Timo, Laru, Johanna, Malkki, Jussi, Pappinen, Sari, Tuunainen, Johanna, Dressman, Jennifer, Hansmann, Simone, Kostewicz, Edmund, He, Handan, Heimbach, Tycho, Wu, Fan, Hoft, Carolin, Laplanche, Loic, Pang, Yan, Bolger, Michael B., Huehn, Eva, Lukacova, Viera, Mullin, James M., Szeto, Ke X., Costales, Chester, Lin, Jian, McAllister, Mark, Modi, Sweta, Rotter, Charles, Varma, Manthena, Wong, Mei, Mitra, Amitava, Bevernage, Jan, Biewenga, Jeike, Van Peer, Achiel, Lloyd, Richard, Shardlow, Carole, Langguth, Peter, Mishenzon, Irina, Nguyen, Mai Anh, Brown, Jonathan, Lennernäs, Hans, Abrahamsson, Bertil

Publikováno v: In European Journal of Pharmaceutical Sciences 1 January 2017 96:610-625

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Autor: Darwich, Adam, Aarons, Leon, Galetin, Aleksandra, Rostami-Hochaghan et al, Amin, Margolskee, Alison, Pepin, Xavier, Carlert, Sara, Hammarberg, Maria, Hilgendorf, Constanze, Johansson, Pernilla, Karlsson, Eva, Murphy, Donal, Tannergren, Christer, Thorn, Helena, Yasin, Mohammed, Mazuir, Florent, Nicolas, Olivier, Ramusovic, Sergej, Xu, Christine, Pathak, Shriram, Korjamo, Timo, Laru, Johanna, Malkki, Jussi, Pappinen, Sari, Tuunainen, Johanna, Dressman, Jennifer, Hansmann, Simone, Kostewicz, Edmund S., He, Handan, Heimbach, Tycho, Wu, Fan, Hoft, Carolin, Pang, Yan, Bolger, Michael, Huehn, Eva, Bolger, Michael B., Lukacova, Viera, Mullin, James M., Szeto, Ke X., Costales, Chester, Lin, Jian, McAllister, Mark, Modi, Sweta, Rotter, Charles, Varma, Manthena, Wong, Mei, Mitra, Amitava, Bevernage, Jan, Biewenga, Jeike, Peer, Achiel Van, Lloyd, Richard, Shardlow, Carole, Langguth, Peter, Mishenzon, Irina, Nguyen, Mai Anh, Brown, Jonathan, Lennerans, Hans, Abrahmsson, Bertil

Publikováno v: Darwich, A, Aarons, L, Galetin, A, Rostami-Hochaghan et al, A, Margolskee, A, Pepin, X, Carlert, S, Hammarberg, M, Hilgendorf, C, Johansson, P, Karlsson, E, Murphy, D, Tannergren, C, Thorn, H, Yasin, M, Mazuir, F, Nicolas, O, Ramusovic, S, Xu, C, Pathak, S, Korjamo, T, Laru, J, Malkki, J, Pappinen, S, Tuunainen, J, Dressman, J, Hansmann, S, Kostewicz, E S, He, H, Heimbach, T, Wu, F, Hoft, C, Pang, Y, Bolger, M, Huehn, E, Heimbach, T, Wu, F, Hoft, C, Pang, Y, Bolger, M B, Huehn, E, Lukacova, V, Mullin, J M, Szeto, K X, Costales, C, Lin, J, McAllister, M, Modi, S, Rotter, C, Varma, M, Wong, M, Mitra, A, Bevernage, J, Biewenga, J, Peer, A V, Lloyd, R, Shardlow, C, Langguth, P, Mishenzon, I, Nguyen, M A, Brown, J, Lennerans, H & Abrahmsson, B 2017, ' IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes ', European Journal of Pharmaceutical Sciences, vol. 96, pp. 626-642 . https://doi.org/10.1016/j.ejps.2016.09.037

Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded “bottom-up” a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d5019a6c0e6692aec365a470b50b25
https://pure.manchester.ac.uk/ws/files/46273976/Darwich_2016_IMI_ORBITO_3.pdf