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Autor:
Sudwarts, Ari, Ramesha, Supriya, Gao, Tianwen, Ponnusamy, Moorthi, Wang, Shuai, Hansen, Mitchell, Kozlova, Alena, Bitarafan, Sara, Kumar, Prateek, Beaulieu-Abdelahad, David, Zhang, Xiaolin, Collier, Lisa, Szekeres, Charles, Wood, Levi B., Duan, Jubao, Thinakaran, Gopal, Rangaraju, Srikant
Additional file 6: Fig. S6. Deletion of microglial Bin1 does not impact cell morphology. (A) Following the deletion of Bin from microglia (Cx3cr1CreER-Bin1 cKO), no obvious change in microglial morphology was observed. There didn’t seem to be any e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334fb72ae40580fdca73a7442c7a2438
Autor:
Sudwarts, Ari, Ramesha, Supriya, Gao, Tianwen, Ponnusamy, Moorthi, Wang, Shuai, Hansen, Mitchell, Kozlova, Alena, Bitarafan, Sara, Kumar, Prateek, Beaulieu-Abdelahad, David, Zhang, Xiaolin, Collier, Lisa, Szekeres, Charles, Wood, Levi B., Duan, Jubao, Thinakaran, Gopal, Rangaraju, Srikant
Additional file 4: Fig. S4. Transcript cluster analysis of in vitro dataset demonstrates the extent of transcriptional dysregulation by Bin1 KD in primary cultured microglia. (A) Volcano plot of transcript expression following LPS exposure identifies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47eefef75eea4773d54e0033c6dd7a5a
Autor:
Sudwarts, Ari, Ramesha, Supriya, Gao, Tianwen, Ponnusamy, Moorthi, Wang, Shuai, Hansen, Mitchell, Kozlova, Alena, Bitarafan, Sara, Kumar, Prateek, Beaulieu-Abdelahad, David, Zhang, Xiaolin, Collier, Lisa, Szekeres, Charles, Wood, Levi B., Duan, Jubao, Thinakaran, Gopal, Rangaraju, Srikant
Additional file 9: Fig. S9. Generation of BV2 KO microglia lacking BIN1 expression by CRISPR/Cas9 gene editing. (A) Lentiviral constructs expressing a sgRNA targeting a region within the Bin1 invariant exon 3 (KO) or a non-target sgRNA were used to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870aec1b1b252092424df36aaf4a1f8b
Autor:
Sudwarts, Ari, Ramesha, Supriya, Gao, Tianwen, Ponnusamy, Moorthi, Wang, Shuai, Hansen, Mitchell, Kozlova, Alena, Bitarafan, Sara, Kumar, Prateek, Beaulieu-Abdelahad, David, Zhang, Xiaolin, Collier, Lisa, Szekeres, Charles, Wood, Levi B., Duan, Jubao, Thinakaran, Gopal, Rangaraju, Srikant
Additional file 7: Fig. S7. Summary of in vivo transcriptional changes and cytokine production. (A-B) Genes which are positively (A) and negatively (B) regulated by BIN1 (i.e., decrease and increase respectively with Bin1 knockout) are summarised fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796d497283e8252184b89f2506c12f39
Autor:
Sudwarts, Ari, Ramesha, Supriya, Gao, Tianwen, Ponnusamy, Moorthi, Wang, Shuai, Hansen, Mitchell, Kozlova, Alena, Bitarafan, Sara, Kumar, Prateek, Beaulieu-Abdelahad, David, Zhang, Xiaolin, Collier, Lisa, Szekeres, Charles, Wood, Levi B., Duan, Jubao, Thinakaran, Gopal, Rangaraju, Srikant
Additional file 5: Fig. S5. Flow cytometry gating strategy for mouse brain-isolated microglia, weight, and temperature analysis during LPS injections. (A) Cells isolated from mouse brains were gated by scatter (single mononuclear cells) and fluoresce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5c7a58ff5c7c5a3641055519543a00
Autor:
Sudwarts, Ari, Ramesha, Supriya, Gao, Tianwen, Ponnusamy, Moorthi, Wang, Shuai, Hansen, Mitchell, Kozlova, Alena, Bitarafan, Sara, Kumar, Prateek, Beaulieu-Abdelahad, David, Zhang, Xiaolin, Collier, Lisa, Szekeres, Charles, Wood, Levi B., Duan, Jubao, Thinakaran, Gopal, Rangaraju, Srikant
Additional file 8: Fig. S8. Whole-brain qRT-PCR analysis of selected homeostatic- and DAM-related genes, and master myeloid-regulating transcription factor. Raw dataset for the analysis summarised in Fig. 8A. Transcript levels of genes encoding homeo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ac7ac487a6758794d1e0724d592d67
Autor:
Sudwarts, Ari, Ramesha, Supriya, Gao, Tianwen, Ponnusamy, Moorthi, Wang, Shuai, Hansen, Mitchell, Kozlova, Alena, Bitarafan, Sara, Kumar, Prateek, Beaulieu-Abdelahad, David, Zhang, Xiaolin, Collier, Lisa, Szekeres, Charles, Wood, Levi B., Duan, Jubao, Thinakaran, Gopal, Rangaraju, Srikant
Additional file 1: Fig. S1. BIN1 expression in mouse and human microglia from transcriptomic and proteomic datasets. (A-B) BIN1 transcript and protein levels in brain cells reported in large-scale datasets. (A) Transcript abundances from purified neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8756b9d6d96bd208cc1ac2e3aa87e0ba
Autor:
Sudwarts, Ari, Ramesha, Supriya, Gao, Tianwen, Ponnusamy, Moorthi, Wang, Shuai, Hansen, Mitchell, Kozlova, Alena, Bitarafan, Sara, Kumar, Prateek, Beaulieu-Abdelahad, David, Zhang, Xiaolin, Collier, Lisa, Szekeres, Charles, Wood, Levi B., Duan, Jubao, Thinakaran, Gopal, Rangaraju, Srikant
Additional file 2: Fig. S2. Exon 11 splicing in microglia. (A) RT-PCR across exon 11 found no inclusion of exon 11 in FACS-isolated microglia from mouse brain, with no change in splicing following LPS injections (left). iMG cells differentiated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bac89136fa9efb2c6863510195ab3fc
Autor:
Sudwarts, Ari, Ramesha, Supriya, Gao, Tianwen, Ponnusamy, Moorthi, Wang, Shuai, Hansen, Mitchell, Kozlova, Alena, Bitarafan, Sara, Kumar, Prateek, Beaulieu-Abdelahad, David, Zhang, Xiaolin, Collier, Lisa, Szekeres, Charles, Wood, Levi B., Duan, Jubao, Thinakaran, Gopal, Rangaraju, Srikant
Additional file 3: Fig. S3. Bin1 siRNA treatment of primary microglia dysregulates DAM gene transcripts without affecting cell viability. CD11b + enriched primary mouse microglia (p0-3) were cultured for 48 h in the presence of either sham siRNA or B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b1b08abf5c3c7d485e12bff6ad57ed