Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Sze Wah Tse"'
Autor:
Susanna Canali, Alexander W. Fischer, Mychael Nguyen, Karl Anderson, Lorna Wu, Anne-Renee Graham, Chiaowen Joyce Hsiao, Chinmayi Bankar, Nancy Dussault, Veronica Ritchie, Meagan Goodridge, Todd Sparrow, Allison Pannoni, Sze-Wah Tse, Vivienne Woo, Kaitlin Klovdahl, Jared Iacovelli, Eric Huang
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101965- (2024)
Objective: Interleukin (IL)-22 is a potential therapeutic protein for the treatment of metabolic diseases such as obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease due to its involvement in multiple cellular pathw
Externí odkaz:
https://doaj.org/article/1607d00e88f946c5834284e04933fa31
Autor:
Seymour de Picciotto, Nicholas DeVita, Chiaowen Joyce Hsiao, Christopher Honan, Sze-Wah Tse, Mychael Nguyen, Joseph D. Ferrari, Wei Zheng, Brian T. Wipke, Eric Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
IL-2 has been used to expand regulatory T (Treg) cells for treating inflammatory disorders. Here the authors test an engineered IL-2 mutein, delivered subcutaneously as mRNA, to show its increased specificity for activating and expanding Treg cells i
Externí odkaz:
https://doaj.org/article/970f3a986644427281a56650bf34012f
Autor:
Eric Yi-Chun Huang, Clayton Small, William Walker, Tal Zaks, Jared Iacovelli, Kristine Mckinney, Kristen Hopson, Sze-Wah Tse, Mychael Nguyen
Publikováno v:
Molecular Therapy. 29:2227-2238
mRNA vaccines induce potent immune responses in preclinical models and clinical studies. Adjuvants are used to stimulate specific components of the immune system to increase immunogenicity of vaccines. We utilized a constitutively active mutation (V1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18e4ec0b2702e16425dfb445cc1bf7d6
https://doi.org/10.1016/j.ymthe.2021.03.002
https://doi.org/10.1016/j.ymthe.2021.03.002
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 106, Iss suppl 1, Pp 172-178 (2011)
CD8+ T cells against malaria liver stages represent a major protective immune mechanism against infection. Following induction in the peripheral lymph nodes by dendritic cells (DCs), these CD8+ T cells migrate to the liver and eliminate parasite infe
Externí odkaz:
https://doaj.org/article/7bee6248e5ff4f4ab898f639f28d0d86
Autor:
Andrea J Radtke, Wolfgang Kastenmüller, Diego A Espinosa, Michael Y Gerner, Sze-Wah Tse, Photini Sinnis, Ronald N Germain, Fidel P Zavala, Ian A Cockburn
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004637 (2015)
Malaria infection begins when a female Anopheles mosquito injects Plasmodium sporozoites into the skin of its host during blood feeding. Skin-deposited sporozoites may enter the bloodstream and infect the liver, reside and develop in the skin, or mig
Externí odkaz:
https://doaj.org/article/fc456f521ca44b5994215478590319b0
Autor:
Seymour de Picciotto, Nicholas DeVita, Chiaowen Joyce Hsiao, Christopher Honan, Sze-Wah Tse, Mychael Nguyen, Joseph D. Ferrari, Wei Zheng, Brian T. Wipke, Eric Huang
Publikováno v:
Nature communications. 13(1)
Interleukin-2 (IL-2) is critical for regulatory T cell (Treg) function and homeostasis. At low doses, IL-2 can suppress immune pathologies by expanding Tregs that constitutively express the high affinity IL-2Rα subunit. However, even low dose IL-2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b4d6556eb9021fc9cbf7e07f8f8c33
https://pubmed.ncbi.nlm.nih.gov/35790728
https://pubmed.ncbi.nlm.nih.gov/35790728
Autor:
Yaman Lu, Krista L. Namminga, Howard E. Gendelman, Brian T. Wipke, Katherine E. Olson, Eric Huang, Clayton Small, Sze-Wah Tse, Jared Iacovelli, William Walker, Seymour De Picciotto, R. Lee Mosley, Mackenzie J. Thurston, Aaron D. Schwab
Publikováno v:
Biomaterials
Restoring numbers and function of regulatory T cells (Tregs) is a novel therapeutic strategy for neurodegenerative disorders. Whether Treg function is boosted by adoptive cell transfer, pharmaceuticals, or immune modulators, the final result is a rob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916fade2ee7b6c26fd6ef46efa15c50b
https://pubmed.ncbi.nlm.nih.gov/33839625
https://pubmed.ncbi.nlm.nih.gov/33839625
Autor:
Sze-Wah, Tse, Kristine, McKinney, William, Walker, Mychael, Nguyen, Jared, Iacovelli, Clayton, Small, Kristen, Hopson, Tal, Zaks, Eric, Huang
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 29(7)
mRNA vaccines induce potent immune responses in preclinical models and clinical studies. Adjuvants are used to stimulate specific components of the immune system to increase immunogenicity of vaccines. We utilized a constitutively active mutation (V1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e23022f09bfa23ca0de862cdeb5f9f3
https://pubmed.ncbi.nlm.nih.gov/33677092
https://pubmed.ncbi.nlm.nih.gov/33677092
Autor:
Ian A Cockburn, Sze-Wah Tse, Andrea J Radtke, Prakash Srinivasan, Yun-Chi Chen, Photini Sinnis, Fidel Zavala
Publikováno v:
PLoS Pathogens, Vol 7, Iss 3, p e1001318 (2011)
Malaria-protective CD8+ T cells specific for the circumsporozoite (CS) protein are primed by dendritic cells (DCs) after sporozoite injection by infected mosquitoes. The primed cells then eliminate parasite liver stages after recognizing the CS epito
Externí odkaz:
https://doaj.org/article/7afa3a0df64f4b5fa5c365e4fc44c8aa
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15948 (2011)
CD4(+) helper T cells are critical orchestrators of immune responses to infection and vaccination. During primary responses, naïve CD8(+) T cells may need "CD4 help" for optimal development of memory populations. The immunological factors attributed
Externí odkaz:
https://doaj.org/article/7765e743fd044d18bb8612b84fd5dade