Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sze Ling Ng"'
Autor:
Elisabeth Mulazzani, Klara Kong, Juan I. Aróstegui, Ashley P. Ng, Nishika Ranathunga, Waruni Abeysekera, Alexandra L. Garnham, Sze-Ling Ng, Paul J. Baker, Jacob T. Jackson, John D. Lich, Margaret L. Hibbs, Ian P. Wicks, Cynthia Louis, Seth L. Masters
Publikováno v:
Nature Immunology. 24:814-826
Missense mutations in PLCG2 can cause autoinflammation with phospholipase C gamma 2-associated antibody deficiency and immune dysregulation (APLAID). Here, we generated a mouse model carrying an APLAID mutation (p.Ser707Tyr) and found that inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3359af22043c30f9c02a487a29c4123d
https://doi.org/10.1038/s41590-023-01473-6
https://doi.org/10.1038/s41590-023-01473-6
Autor:
Humphries, Fiachra, Shmuel-Gali, Liraz, Zhaozhao Jiang, Zhou, Jeffrey Y., Barasa, Leonard, Mondal, Santanu, Wilson, Ruth, Sultana, Nadia, Shaffer, Scott A., Sze-Ling Ng, Pesiridis, G. Scott, Thompson, Paul R., Fitzgerald, Katherine A.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 8/15/2023, Vol. 120 Issue 33, p1-10, 15p
Publikováno v:
Asia-Pacific Journal of Business Administration.
PurposeThe objective of this study is to examine the drivers of retail apps satisfaction and continuance intention. An integrative theoretical framework was developed based on the IS success model, E-S-QUAL and expectancy and disconfirmation model to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3415e196f83ab9c5f2bab848655c3e
https://doi.org/10.1108/apjba-08-2021-0408
https://doi.org/10.1108/apjba-08-2021-0408
Publikováno v:
Immunology
Humanized double transgenic mice express both HLA-DR15 (the MHC gene linked to MS) and TCR.Ob1A12 from a multiple sclerosis patient (that recognizes MBP85-99 presented by HLA-DR15), yet they fail to develop autoimmune encephalomyelitis quickly, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdfa19bdaf2cc1022bb91ce83dbae32
https://doi.org/10.1111/imm.13321
https://doi.org/10.1111/imm.13321
Autor:
Amede Larabi, Juliette M. Devos, Sze-Ling Ng, Max H. Nanao, Adam Round, Tom Maniatis, Daniel Panne
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 734-746 (2013)
Tank-binding kinase I (TBK1) plays a key role in the innate immune system by integrating signals from pattern-recognition receptors. Here, we report the X-ray crystal structures of inhibitor-bound inactive and active TBK1 determined to 2.6 Å and 4.0
Externí odkaz:
https://doaj.org/article/f5bd41946b59419fb6925a7bc6c42a50
Autor:
Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly
Publikováno v:
Journal of Medicinal Chemistry. 62:5096-5110
RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently, RIP1 kinase inhibitors have advanced into early clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ff65b82b2e1feff6acc28b9dcac4dc
https://doi.org/10.1021/acs.jmedchem.9b00318
https://doi.org/10.1021/acs.jmedchem.9b00318
Autor:
Sze-Ling Ng, René Maehr, Angel I. Morales-Ramos, Krishna-Mohan Parsi, Philip S. Landis, Liraz Shmuel-Galia, Zhaozhao Jiang, G. Scott Pesiridis, John Cruz, Ruth Wilson, Ramanjulu Joshi M, John Bertin, Katherine A. Fitzgerald, Fiachra Humphries
Publikováno v:
Science Immunology
Coronaviruses are a family of RNA viruses that cause acute and chronic diseases of the upper and lower respiratory tract in humans and other animals. SARS-CoV-2 is a recently emerged coronavirus that has led to a global pandemic causing a severe resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2b3c59cc869de73c5ad849923be7da
http://europepmc.org/articles/PMC8158975
http://europepmc.org/articles/PMC8158975
Random amino acid copolymers used in the treatment of multiple sclerosis in man or experimental autoimmune encephalomyelitis (EAE) in mice [poly(Y,E,A,K)(n), known as Copaxone, and poly(Y,F,A,K)(n)] function at least in part by generation of IL-10–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174994c596d0097caf19d5931b1436bb
https://europepmc.org/articles/PMC6377493/
https://europepmc.org/articles/PMC6377493/
Autor:
Stephanie N. Regan, Daniel J. Rader, Bridget Gosis, Chad A. Cowan, Qiurong Ding, Sze-Ling Ng, Kevin M. Patel, Alanna Strong, Kiran Musunuru
Publikováno v:
Circulation Research. 115:488-492
Rationale : Individuals with naturally occurring loss-of-function proprotein convertase subtilisin/kexin type 9 ( PCSK9 ) mutations experience reduced low-density lipoprotein cholesterol levels and protection against cardiovascular disease. Objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2094a943318b13b9d73cc5b5c41d0c24
https://doi.org/10.1161/circresaha.115.304351
https://doi.org/10.1161/circresaha.115.304351
Autor:
tenOever, Benjamin R.1, Sze-Ling Ng1, Chua, Mark A.2,3, McWhirter, Sarah M.1, García-Sastre, Adolfo2,4, Maniatis, Tom1 maniatis@mcb.harvard.edu
Publikováno v:
Science. 3/2/2007, Vol. 315 Issue 5816, p1274-1278. 5p. 2 Graphs.