Validating Differential Volatilome Profiles in Parkinson’s Disease

Autor: Eleanor Sinclair, Caitlin Walton-Doyle, Depanjan Sarkar, Katherine A. Hollywood, Joy Milne, Sze Hway Lim, Tilo Kunath, Anouk M. Rijs, Rob M. A. de Bie, Monty Silverdale, Drupad K. Trivedi, Perdita Barran

Publikováno v: ACS Central Science, Vol 7, Iss 2, Pp 300-306 (2021)

Externí odkaz: https://doaj.org/article/61914eed69b4433196490a6d54ff8a52

Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy

Autor: Alexandra Marquez, Lucie S. Guernsey, Katie E. Frizzi, Morgan Cundiff, Isabel Constantino, Nabeel Muttalib, Fernanda Arenas, Xiajun Zhou, Sze Hway Lim, Maryam Ferdousi, Georgios Ponirakis, Monty Silverdale, Christopher Kobylecki, Matthew Jones, Andrew Marshall, Rayaz A. Malik, Corinne G. Jolivalt

Publikováno v: Neurobiology of Disease, Vol 151, Iss , Pp 105273- (2021)

Pathological hyperphosphorylated tau is a key feature of Alzheimer's disease (AD) and Frontotemporal dementia (FTD). Using transgenic mice overexpressing human non-mutated tau (htau mice), we assessed the contribution of tau to peripheral and central

Externí odkaz: https://doaj.org/article/c8ce0d5558844a68a30da698b9499e41

Paper Spray Ionization Ion Mobility Mass Spectrometry of Sebum Classifies Biomarker Classes for the Diagnosis of Parkinson's Disease

Autor: Monty Silverdale, Kaneez Jafri, Johannes P. C. Vissers, Keith Richardson, Caitlin Walton-Doyle, Eleanor Sinclair, Perdita E. Barran, Joy Milne, Sze Hway Lim, Depanjan Sarkar, Drupad Trivedi

Publikováno v: Sarkar, D, Sinclair, E, Lim, S H, Walton-Doyle, C, Jafri, K, Milne, J, Vissers, J P C, Richardson, K, Trivedi, D K, Silverdale, M & Barran, P 2022, ' Paper Spray Ionization Ion Mobility Mass Spectrometry of Sebum Classifies Biomarker Classes for the Diagnosis of Parkinson's Disease ', JACS Au, vol. 2, no. 9, pp. 2013-2022 . https://doi.org/10.1021/jacsau.2c00300

Parkinson’s disease (PD) is the second most common neurodegenerative disorder and identification of robust biomarkers to complement clinical diagnosis will accelerate treatment options. Here we demonstrate the use of direct infusion of sebum from s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e3b6cf5ff13c330462125e2e854d18
http://www.scopus.com/inward/record.url?scp=85139221703&partnerID=8YFLogxK

Validating differential volatilome profiles in Parkinson’s disease

Autor: Monty Silverdale, Tilo Kunath, Joy Milne, Rob M.A. de Bie, Sze Hway Lim, Anouk M. Rijs, Depanjan Sarkar, Drupad K. Trivedi, Caitlin Walton-Doyle, Katherine A. Hollywood, Perdita E. Barran, Eleanor Sinclair

Publikováno v: Sinclair, E, Walton-Doyle, C, Sarkar, D, Hollywood, K A, Milne, J, Lim, S H, Kunath, T, Rijs, A M, De Bie, R M A, Silverdale, M, Trivedi, D K & Barran, P 2021, ' Validating differential volatilome profiles in Parkinson’s disease ', ACS Central Science, vol. 7, no. 2, pp. 300-306 . https://doi.org/10.1021/acscentsci.0c01028
ACS central science, 7(2), 300-306. American Chemical Society
Acs Central Science, 7, 2, pp. 300-306
Sinclair, E, Walton-Doyle, C, Sarkar, D, Hollywood, K A, Milne, J, Lim, S H, Kunath, T, Rijs, A M, de Bie, R M A, Silverdale, M, Trivedi, D K & Barran, P 2021, ' Validating differential volatilome profiles in Parkinson's disease ', ACS Central Science, vol. 7, no. 2, pp. 300-306 . https://doi.org/10.1021/acscentsci.0c01028
ACS Central Science, Vol 7, Iss 2, Pp 300-306 (2021)
ACS Central Science, 7(2), 300-306. American Chemical Society
Acs Central Science, 7, 300-306
ACS Central Science

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that does not currently have a robust clinical diagnostic test. Nonmotor symptoms such as skin disorders have long since been associated with the disease, and more recently a char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0056f993f29c76e87d8044d8ded1d042
https://www.pure.ed.ac.uk/ws/files/199336730/acscentsci.0c01028.pdf

Corneal confocal microscopy detects small fibre neurodegeneration in Parkinson's disease using automated analysis

Autor: Ioannis N. Petropoulos, Maryam Ferdousi, Monty Silverdale, Rayaz A. Malik, Lewis Kass-Iliyya, Christopher Kobylecki, Alise Kalteniece, Sze Hway Lim

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Lim, S H, Ferdousi, M, Kalteniece, A, Kass-Iliyya, L, Petropoulos, I, Malik, R, Kobylecki, C & Silverdale, M 2020, ' Corneal confocal microscopy detects small fibre neurodegeneration in Parkinson's disease using automated analysis ', Scientific Reports, vol. 10, no. 1 . https://doi.org/10.1038/s41598-020-76768-x

We studied the utility of corneal confocal microscopy (CCM) in detecting a reduction in corneal nerve parameters in a large cohort of patients with Parkinson’s disease (PD) compared to controls using a fully automated potentially scalable method of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be514d34fbe0362456ecbea58372b685
https://doi.org/10.1038/s41598-020-76768-x